A new scenario for prebiotic formation of nucleic acid oligomers
is presented by Wieczorek et al in CHEMBIOCHEM. Peptide catalysis is applied to achieve condensation of activated RNA monomers into short RNA chains. Reactions were carried out in selforganised environment, a water-ice eutectic phase, with low concentrations of reactants. Because peptides are much more likely products of spontaneous condensation than nucleotide chains, their potential as catalysts for the formation of RNA is interesting from
the origin-of-life perspective.
Formation of RNA Phosphodiester Bond by Histidine-Containing Dipeptides