Evolution is a tricky game between exploration and fixation. Extremely high mutation rates (MRs) lead to error catastrophe. Conversely, unusually low MRs inhibit adaptation to changing environments.
Montero and co-workers investigate the time a phenotype takes to reach fitness peak as function of both fitness landscape and its mutation rate. Researchers evaluate the average time that the system takes to reach a final steady state of simple models of populations formed by self-replicative sequences (quasispecie).
Arturo Marína, Héctor Tejeroa, Juan Carlos Nuñob, Francisco Monteroa.
Characteristic time in quasispecies evolution
Journal of Theoretical Biology Volume 303, 21 June 2012, Pages 25–32