Lipid compartments (liposomes, lipid-coated droplets) have been extensively used as in vitro "minimal" cell models to shed new light on the origin of life and the basic feature of living system as well. In this paper, Mavelli and Mirazo develop a comprehensive platform called ENVIRONMENT suitable for studying the stochastic time evolution of reacting lipid compartments. The software will allow the investigation of random fluctuations and stochastic events tha may lead an open system towards unexpected time evolutions.
Stochastic simulations of minimal cells: the Ribocell model.
BMC Bioinformatics. 2012 Mar 28;13 Suppl 4:S10.
Mavelli F, Ruiz-Mirazo K.
ENVIRONMENT: a computational platform to stochastically simulate reacting and self-reproducing lipid compartments.
Phys Biol. 2010 Aug 11;7(3):036002.