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Organ Donation & Transplant Matters Resources
Combining reports, research findings and topic reviews
Curated by Deborah Verran
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Study reports liver donors face mortality risk with LDLT - from News-Medical.Net - News-Medical.net

Study reports liver donors face mortality risk with LDLT - from News-Medical.Net - News-Medical.net | Organ Donation & Transplant Matters Resources | Scoop.it

Published Study reports that live liver donors face a mortality risk with LDLT  A study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplant Society has revealed what are the current estimated risks for morbidity and mortality with adult live liver donation...

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Genetics defines a distinct liver disease

Genetics defines a distinct liver disease | Organ Donation & Transplant Matters Resources | Scoop.it
A large-scale genetic study has defined the relationship between primary sclerosing cholangitis and other autoimmune diseases.
Deborah Verran's insight:

Primary sclerosing cholangitis is now revealed to be a distinctive form of liver disease.

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Deadly Parasitic Roundworms Transmitted Through Organ Transplants [PHOTOS] - Medical Daily

Deadly Parasitic Roundworms Transmitted Through Organ Transplants [PHOTOS] - Medical Daily | Organ Donation & Transplant Matters Resources | Scoop.it

Reported online via Medical Daily:
Deadly Parasitic Roundworms (Strongyloides stercoralis) Transmitted Through Organ Transplants [complete with graphics and PHOTOS].


The heart recipient, a 59-year-old with weakened heart muscles, came down with a respiratory illness seven weeks after the transplant. To read more on the outcomes of all of the recipients of the donor organs from this one donor, click on the banner headline

Deborah Verran's insight:

An unusual case of disease transmission via organs from one deceased donor with unrecognised parasitic threadworm infection

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Adolescent classroom education on knowledge and attitudes about deceased organ donation: A systematic review - Li - 2013 - Pediatric Transplantation - Wiley Online Library

Adolescent classroom education on knowledge and attitudes about deceased organ donation: A systematic review - Li - 2013 - Pediatric Transplantation - Wiley Online Library | Organ Donation & Transplant Matters Resources | Scoop.it
An excellent systematic review on adolescent education and organ donation. http://t.co/riAUB5qbWC
Deborah Verran's insight:

Education works. This article will be of interest to anyone involved in delivering education programmes on organ donation in schools

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Artificial Wearable Lung to Help Patients be Mobile Before Transplant - Medgadget.com

Artificial Wearable Lung to Help Patients be Mobile Before Transplant - Medgadget.com | Organ Donation & Transplant Matters Resources | Scoop.it

Reported via Medgadget.com
Research into an artificial Wearable Lung to help patients be mobile prior to lung transplantation. 
 
Patients preparing for a lung transplant often end up bedridden for extended periods of time while awaiting surgery. Hence any advance in technology which could potentially extend the period patients wait whilst allowing them to remain mobile is very important.

 

This is a preliminary report of a device which will need to be trialled on patients.

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On the Impacts of Traditional Chinese Culture on Organ Donation

On the Impacts of Traditional Chinese Culture on Organ Donation | Organ Donation & Transplant Matters Resources | Scoop.it

中国の文化的伝統と臓器提供 From the Journal of Medicine and Philosophy an article on the Impacts of Traditional Chinese Culture on Organ Donation http://t.co/aLWUZqH0td

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CDC Confirms Rabies Death in Organ Transplant Recipient

CDC Confirms Rabies Death in Organ Transplant Recipient | Organ Donation & Transplant Matters Resources | Scoop.it

This week, CDC laboratories tested tissue samples from the donor and from the recipient who died to confirm transmission of rabies through organ transplantation. In early March, the Maryland Department of Health and ...

 

Other commentary from one of the CDC scientists highlighting the unusual nature of this case including the diagnosis being made many months following the transplant procedure via this link-

 

 

http://www.usatoday.com/story/news/nation/2013/03/15/man-dies-of-rabies-from-donated-kidney/1990831/?sf10525060=1 

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Older Circulatory-Death Donor Kidneys Acceptable for Transplant - Renal and Urology News

Older Circulatory-Death Donor Kidneys Acceptable for Transplant - Renal and Urology News | Organ Donation & Transplant Matters Resources | Scoop.it

Reported initially via the medical journal The Lancet is this analysis of United Kingdom data of the outcomes of kidney transplantation from deceased donors. Although older Circulatory-Death Donor Kidneys are acceptable for transplantation the results reflect organ donor selection practices, including during the organ retrieval surgery. Plus as noted in the accompanying editorial there has been a relatively high rate of discardment of deceased donor kidneys within the United Kingdom in recent years.

 

The government-funded study of 6,490 kidney transplants also confirmed that donor age over 60 years compared to age under 40 years is associated with an increased risk of graft loss and inferior longer term graft survival, with there also being an added impact of longer cold storage times.

 

To read the online commentary in Renal & Urology News clisk on the banner headline. Access to the online article is via- http://www.thelancet.com

published the first week of March 2013 

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Groups push for organ donation reform - The Daily Star

Groups push for organ donation reform - The Daily Star | Organ Donation & Transplant Matters Resources | Scoop.it
Groups push for organ donation reform The Daily Star The recommendations include centralizing the country's organ and tissue donations under the National Organization for Organ and Tissue Donation and Transplantation, an organization that works...
Deborah Verran's insight:

News out of Lebanon on calls to formalise policies and processes that could underpin a more effective organ donation system within that country

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The burden of liver disease in Europe: A review of available epidemiological data

The burden of liver disease in Europe: A review of available epidemiological data | Organ Donation & Transplant Matters Resources | Scoop.it

 Published in the Journal of Hepatology a fairly comprehensive review of the currently available epidemiological data on liver disease in Europe.http://t.co/sbuJjxig5J

 

The graphic is summary data from the ELTR Registry on the numbers of liver transplants that have been performed broken down by country.

 

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Capps Introduces Legislation to End Research Ban On Organ Donation From HIV-Positive Donors to HIV-Positive Transplant Recipients | Congresswoman Lois Capps

Capps Introduces Legislation to End Research Ban On Organ Donation From HIV-Positive Donors to HIV-Positive Transplant Recipients | Congresswoman Lois Capps | Organ Donation & Transplant Matters Resources | Scoop.it

News from the United States of legislation being introduced via the #HOPEAct to overturn the ban on organ donation from HIV positive donors. Click on the banner headline to read the report... http://t.co/H1izJ2Lg

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Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses | BMJ

Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses | BMJ | Organ Donation & Transplant Matters Resources | Scoop.it

As reported in the British Medical Journal the objective of this study was to assess the long term effect of United Kingdom legislation introduced in September 1998 to restrict the pack sizes of paracetamol on deaths from paracetamol poisoning and liver unit activity.

 

Although an impact was seen in that there were fewer deaths from paracetamol poisoning, there has not been the same expected drop in the rates of liver transplantation. These results lead the authors of the report to make further recommendations in the discussion section of the report on the marketing of paracetamol.

Deborah Verran's insight:

Paracetamol (or acetaminophen) is the single greatest underlying contributor internationally to cases of acute liver failure due to a medication. This also impacts on the requirement for liver transplantation in the most severe cases.

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Transplants Candidates How Much Does Size Matter

Transplants Candidates How Much Does Size Matter | Organ Donation & Transplant Matters Resources | Scoop.it

Obese individuals often are rejected as renal transplant candidates in large part because of their increased risk for surgical complications and adverse outcomes.

 

This article via Renal and Urology News summarises some of the evidence to date. This includes making the point that abdominal girth may be more important in determining candidacy for renal transplantation over and above body mass index(BMI). Other medical co-morbities associated with obesity also mandate that extra attention be specifically paid to the effects of diabetes and vascular disease on potential transplant recipients.

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Researchers link facial structure to kidney disease - Medical Xpress - Medical Xpress

Researchers link facial structure to kidney disease - Medical Xpress - Medical Xpress | Organ Donation & Transplant Matters Resources | Scoop.it

Reported via Nature World News & Medical Xpress:
Researchers link facial structure to kidney disease
In Autosomal Dominant Polycystic Kidney Disease (ADPKD) which is the most common genetic kidney disorder, there is now some preliminary evidence that there are subtle differences in facial structure compared to individuals without ADPKD.

 

To read more click on the banner headline.

Deborah Verran's insight:

As some of the genetic disorders which are associated with abnormalities of the kidneys are further characterised, expect more information like this to come to hand

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FDA Approves FibroScan(R) For Non-Invasive Liver Diagnosis

FDA Approves FibroScan(R) For Non-Invasive Liver Diagnosis | Organ Donation & Transplant Matters Resources | Scoop.it

Reported via Medical News Today. Echosens(TM) is pleased to announce that the FibroScan(R) device has received 510(k)clearance from the U.S. Food and Drug Administration (FDA) for use as a non-invasive method of  liver imaging.

 

The device is already in use in some parts of the world but penetrating the US market is now a significant development.

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Take A Kidney Transplant Now Or Wait For A Better One? Johns Hopkins Researchers Create Web-Based ‘Decision’ Tool

Take A Kidney Transplant Now Or Wait For A Better One? Johns Hopkins Researchers Create Web-Based ‘Decision’ Tool | Organ Donation & Transplant Matters Resources | Scoop.it

Johns Hopkins scientists in the United States have created a free, Web-based tool to help patients decide whether it's best to accept an immediately available, but less-than-ideal deceased donor kidney for transplant, or wait for a healthier one in the future.

 

This may help some clinicians and patients with respect to decision making at the time that the offer of a deceased donor kidney becomes available. For more information including of an example of how this may work on practice, click on the banner headline.

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6 Social-Media Skills Every Leader needs

6 Social-Media Skills Every Leader needs | Organ Donation & Transplant Matters Resources | Scoop.it

Few domains in business and society have been untouched by the emerging social-media revolution—one that is not even a decade old. Many organizations have been responding to that new reality, realizing the power and the potential of this technology for corporate life: wikis enable more efficient virtual collaboration in cross-functional projects; internal blogs, discussion boards, and YouTube channels encourage global conversations and knowledge sharing; sophisticated viral media campaigns engage customers and create brand loyalty; next-generation products are codeveloped in open-innovation processes; and corporate leaders work on shaping their enterprise 2.0 strategy.


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The Learning Factor's curator insight, April 3, 2013 4:19 PM

Organizational social-media literacy is fast becoming a source of competitive advantage. Learn, through the lens of executives at General Electric, how you and your leaders can keep up. A McKinsey Quarterly Strategy article.

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Wiley: Incarceration, Marijuana Use and Suicide Attempts May Hinder Liver Transplant Eligibility

Wiley: Incarceration, Marijuana Use and Suicide Attempts May Hinder Liver Transplant Eligibility | Organ Donation & Transplant Matters Resources | Scoop.it

As reported in the journal Liver Transplantation: Social Factors May Hinder Liver Transplant Eligibility http://t.co/Io4ZzCTfkZ

 

Liver transplantation is not just a major surgical procedure but is combined with the requirement for life long adherance to a medication regimen (immunosuppressive medications). This means that potential transplant candidates are carefully evaluated for their ability to be able to comply with what is required both prior to and following the transplant procedure. 

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Human livers kept 'alive' out of body in donor breakthrough - The Independent

Human livers kept 'alive' out of body in donor breakthrough - The Independent | Organ Donation & Transplant Matters Resources | Scoop.it

First report out of the United Kingdon of
Human livers being kept 'alive' out of body via new breakthrough machine technology-pictured- prior to transplantation.

 

This machine keeps the donor liver 'warm' and perfused with blood which is in direct contrast with the current method of preserving donor livers which is via static cold storage(at 4 degrees Celsius).

 

Video footage including of how the machine was developed at Oxford University via BBC news-

 

http://youtu.be/8zr2lFe-pxU

 


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Deborah Verran's insight:

This is a preliminary news report on proof of concept. A further European trial of this machine technology is planned as mentioned in the BBC news video.

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Ex Vivo Lung Evaluation of Prearrest Heparinization in Donat... : Annals of Surgery

Ex Vivo Lung Evaluation of Prearrest Heparinization in Donat... : Annals of Surgery | Organ Donation & Transplant Matters Resources | Scoop.it
Objective: To evaluate the effects of prearrest heparin administration on lung quality in a model of donation after cardiac death (DCD), and to assess the potential application of ex vivo lung perfusion (EVLP) in the identification of better grafts...
Deborah Verran's insight:

Publication of research indicating that pre-arrest (antemortem) intravenous heparin improves organ quality in DCD donors

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Government rejects presumed consent - swissinfo.ch

Government rejects presumed consent - swissinfo.ch | Organ Donation & Transplant Matters Resources | Scoop.it

News that the Swiss Government has rejected presumed consent, the reasons for which are stated in the article including mainitaining community trust in organ donation.

 

This now positions Switzerland alongside Spain, the United States, Austria and Australia, who are all working on increasing organ donation as a result of a number of combined and targeted measures,...

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Reimagine the Concept of Education

Reimagine the Concept of Education | Organ Donation & Transplant Matters Resources | Scoop.it

This article highlights a new conceptual approach to education. What Mitra's work shows us that (even in the most unpromising settings and with a shoestring budget) education, like the Web itself, can be "a self-organizing system, where learning is an emergent phenomenon."

Deborah Verran's insight:

This is a pivotal shift in thinking and provides the reader with some important insights as to where education and learning may be heading

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Минздрав разработал правила изъятия органов для трансплантации - МедНовости - MedPortal.ru

Минздрав разработал правила изъятия органов для трансплантации - МедНовости - MedPortal.ru | Organ Donation & Transplant Matters Resources | Scoop.it

This report out of Russia (can be viewed via Google translate) is about the new regulations for organ donation which have been drafted by the Ministry of health.

 

These regulations will shortly be released for public consultation.

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Highly regulated companies tiptoe into social media

Highly regulated companies tiptoe into social media | Organ Donation & Transplant Matters Resources | Scoop.it
Social networking is serious business within regulated industries. Posts pertaining to finance, insurance and healthcare, in particular, require adherence to strict government and industry regulations. However, even with the rule-a-palooza, some companies in these industries have not only found ways to keep regulators happy, but have also made social networking a productive and key part of doing business.

That said, the phenomenon is still in fairly early stages. Only around 10% of the companies in regulated industries have a "truly social" enterprise where multiple social media tools have been integrated into general content consumption, according to Toby Ward, founder of Toronto-based Prescient Digital Media, a consulting firm for Fortune 500 companies.

"It depends on the organization and their level of savviness," he says. Companies where executives start their own blogs, for example, are more likely to use social media effectively and adopt it widely, according to a recent study by Prescient. "Almost all major banks have been in social media for at least a few years," Ward says.

Some healthcare providers, financial services firms and other companies in highly regulated industries are taking full advantage of social media, even though they're awash in rules. Here's how they do it.

 

Read the full article by clicking on the title


Via Chaturika Jayadewa
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Icing Organs | The Scientist Magazine®

Icing Organs | The Scientist Magazine® | Organ Donation & Transplant Matters Resources | Scoop.it

This article explores why scientists are so near and yet so far from being able to cryopreserve organs.

 

This includes an explanation of how cryopreservation works, a summary of the research to date as well as why the anticipated success has not as yet been realised for organ preservation.

 

The majority of organs for transplantation continue to be kept under static cold storage( 4 degrees celsius) conditions. Machine preservation is also being used but is not as yet widespread and is now the subject of ongoing clinical research.

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