Organ Donation & Transplant Matters Resources
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PKM and Corporate Memory - a dichotomy?

The presentation looks specifically at the changing nature of organisations and the emergent power of networks and networking. Personal Knowledge Management (PKM) is a competence we must all learn in order to remain relevant to our organisation. But who ultimately “owns” the ‘corporate’ knowledge that we gather through the workplace networks we nurture and sustain, and do the organisations we work for even recognise the importance of these networks as places for continual learning, knowledge sharing and incubators for innovation?


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Organ Donation & Transplant Matters Resources
Combining reports, research findings and topic reviews
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Human-embryo editing now covered by stem-cell guidelines

Human-embryo editing now covered by stem-cell guidelines | Organ Donation & Transplant Matters Resources | Scoop.it

New international guidelines have just been published by the International Society of Stem Cell Research (ISSCR), which cover all aspects of stem-cell research. This is an attempt to fend off the need for further government regulation that could impede this particular  research including the manipulation of human embryos in the laboratory setting.


To read more on this story click on the following link-


http://www.nature.com/news/human-embryo-editing-now-covered-by-stem-cell-guidelines-1.19909


In addition calls are being made for there to be more realistic and responsible reporting of stem cell research which has suffered in recent years from 'too much hype'-



http://www.bloomberg.com/news/articles/2016-05-12/stop-hyping-stem-cell-science-say-stem-cell-scientists


Deborah Verran's insight:
This will be of interest to anyone following the current research into stem cells and tissue engineering
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Vatican meeting calls organ trafficking a crime against humanity

Vatican meeting calls organ trafficking a crime against humanity | Organ Donation & Transplant Matters Resources | Scoop.it

After a conference on organ trafficking at the Vatican Feb. 7-8, participants signed a statement agreeing to unite in fighting the crime of organ trafficking – submitting 11 proposals for implementation by healthcare and law enforcement professionals around the world.


For more on this story along with the formal release including the 11 proposals click on the following link-

http://en.radiovaticana.va/news/2017/02/09/vatican_organ_trafficking_summit_issues_statement/1291387


Deborah Verran's insight:
The proposals will be of interest to professionals who have an interest in this subject
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Human-Animal Hybrid: Scientists Grow Human Cells Inside Pig Embryos

Human-Animal Hybrid: Scientists Grow Human Cells Inside Pig Embryos | Organ Donation & Transplant Matters Resources | Scoop.it

Scientists injected pig embryos with human stem cells to produce animal embryos that contain human cells. What are the dangers and potential benefits of this technology? This is explored in the full article which can be accessed via clicking on the banner headline.


This online article is the result of the publication of the findings of sophisticated laboratory research into the creation of embryos which contain cells from two different animals. In the research quoted above this involved placing genetically modified human stem cells into pig blastocysts (at the pre-embryo stage). Despite evidence of the human stem cells initially surviving there was limited evidence of them being present at the pig embryo stage as outlined in the full scientific report-


http://www.cell.com/cell/fulltext/S0092-8674(16)31752-4


Despite the headlines generated in some quarters by this particular research, this does not mean that the transplantation of organs from 'humanized pigs' is just around the corner as may have been implied.



Deborah Verran's insight:
This proof of concept study will now need to be followed by more sophisticated research in order to ascertain whether this will lead to so called humanized organs in pigs.
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Air-Powered Robotic Sleeve Wraps Around Your Heart To Keep It Pumping

Air-Powered Robotic Sleeve Wraps Around Your Heart To Keep It Pumping | Organ Donation & Transplant Matters Resources | Scoop.it
Researchers from Harvard University and Boston Children's Hospital have developed an innovative robotic sleeve that fits around the heart. As outlined in this online report  the device (pictured) has been successfully trialed in large animals and hence satisfies proof of concept criteria. However in order for the device to meet stringent regulatory standards prior to then being marketed it must now undergo prospective trials in humans.

One advantage of this particular device is that it wraps around the heart and hence is not in contact with circulating blood which can lead to other problems such as excessive clotting.

The relevant research article which has now been published in Science Translational Medicine can be accessed via the following link-

Deborah Verran's insight:
This is an interesting new type of cardiac assist device which now needs to be trialed in humans
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Sgt. Darrick Kepley makes emergency organ delivery after SUV crash

Sgt. Darrick Kepley makes emergency organ delivery after SUV crash | Organ Donation & Transplant Matters Resources | Scoop.it
While patrolling in a town in Pennsylvania’s Lancaster County in the snow last Saturday, Sgt. Darrick Kepley happened across a one-car crash

Inside the crashed vehicle were an organ retrieval team who were on their way back to their base hospital (the Thomas Jefferson in Philadelphia), including with a donor liver.

In order to prevent any further delays Sgt Kepley then transported the team to the hospital so that a liver transplant procedure could continue as scheduled.
Deborah Verran's insight:
Unforseen problems with the ground transportation of donor organs can lead to alternative measures having to be adopted at short notice
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A Dying Man's Wish To Donate His Organs Gets Complicated

A Dying Man's Wish To Donate His Organs Gets Complicated | Organ Donation & Transplant Matters Resources | Scoop.it
Dying in America doesn't always go the way we plan. One terminally ill man's hope to be disconnected from his respirator and donate his organs was almost thwarted, despite his best laid plans.

Despite the wishes of David Adox to donate his organs and the agreement of physicians in a nearby hospital, the lawyers for this particular  hospital blocked the proposed organ donation. Fortunately professionals in an organ procurement organization heard about David's plight and were able to make arrangements for his wishes to be carried out in another hospital in New York.

As outlined in the article, donation after circulatory death is an established practice in many parts of the United States. Patients with progressive neurological conditions can opt to cease their treatment and then donate their organs if they go on to decease within a certain time period. There are guidelines as well as protocols in place both within organ procurement organizations as well as hospitals.

This article highlights the confusion as well as the conflict that can arise within an institution when not everyone is on the same page about modern established practices in organ donation.
Deborah Verran's insight:
Important story and a reminder that hospitals must have established protocols for DCD organ donation in the countries around the world where the practice is now established
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Is There a Better Way to Allocate Organs to Transplant Patients?

Is There a Better Way to Allocate Organs to Transplant Patients? | Organ Donation & Transplant Matters Resources | Scoop.it
This opinion piece is about one important issue patients face whilst on the waiting list for a kidney within the United States. That is whether to accept the first offer they receive of a donor kidney or to wait for a better offer. This conundrum is partly behind the current rate of discards for deceased donor kidneys within the United States.

Researchers who were interviewed for this story have come up with two more ideas for changing this system where people linger on waitlists while a significant percentage of kidneys continue to be discarded.

One option is to provide both the physicians and the patient's with a lot more data on perceived waiting times for differing organ allocation scenarios.

This article will be of interest to healthcare professionals as well as patients.
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The heavy-on-hype, light-on-substance world of drone delivery

The heavy-on-hype, light-on-substance world of drone delivery | Organ Donation & Transplant Matters Resources | Scoop.it
Companies routinely get attention for media-friendly one-off deliveries via drone, but few are currently doing any of this at scale after more than half a decade. 

There are a number of barriers to the use of drones, with meeting strict regulatory requirements being one of them. In addition the size of the drone may limit what can be carried, along with there being limits for what are the ideal and hence the safest flying conditions.

There seem to be a number of challenges that need to be worked through before the use of this type of technology can become more widespread.
Deborah Verran's insight:
There will also be a requirement to meet all of the quality, safety and regulatory requirements pertaining to the delivery of blood and/or human organs.
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Multi-drug resistant infection spreading globally among cystic fibrosis patients

Multi-drug resistant infection spreading globally among cystic fibrosis patients | Organ Donation & Transplant Matters Resources | Scoop.it
There are concerns that the pathogen mycobacterium abscessus which is notoriously difficult to treat, will prevent some patients undergoing lung transplantation. As reported this last week this pathogen tends to occur in patients with lung disease due to cystic fibrosis.

The study, led by the University of Cambridge and the Wellcome Trust Sanger Institute in the United Kingdom, also suggests that conventional cleaning will not be sufficient to eliminate this particular pathogen, which can be transmitted through contaminated surfaces or in the air.
Deborah Verran's insight:
Important information for healthcare professionals involved in caring for patients being considered for lung transplantation
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Capacity Building for Hospital Staff Pays Off with First Kidney Transplant in Afghanistan

Capacity Building for Hospital Staff Pays Off with First Kidney Transplant in Afghanistan | Organ Donation & Transplant Matters Resources | Scoop.it

Doctors at a hospital in Herat city have carried out the country’s first kidney transplant after a programme for the training of healthcare workers in the diagnosis and treatment of renal disease was successfully implemented.


Up to now patients in Afghanistan with chronic kidney disease needed to travel to other countries in order to be able to undergo a kidney transplant. In addition they were faced with significant financial costs which were a major barrier for many individuals and their families.



Deborah Verran's insight:
An important development within Afghanistan which hopefully can be sustained.
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How six healthy kidneys saved 140 lives

How six healthy kidneys saved 140 lives | Organ Donation & Transplant Matters Resources | Scoop.it
An important kidney swapping system is now saving lives all across the United States. 

This article provides an outline on how altruistic live kidney donors are contributing to the so called kidney exchanges which then allow a chain of liver donor kidney transplant procedures to be performed.

This article also contains the stories of some of the individuals who went ahead and donated a kidney after they received medical clearance.


Deborah Verran's insight:
A concise well written article on how paired live donor kidney exchange works
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Heart transplant infrastructure in India very poor: Health experts

Heart transplant infrastructure in India very poor: Health experts | Organ Donation & Transplant Matters Resources | Scoop.it
Cardiovascular diseases (CVDs) are the number one cause of death globally, leading to more deaths annually than from any other cause.

In India the rates of heart transplantation currently lag behind other developed countries. The reasons for this fall into three main categories:, lack of infrastructure, logistical constraints (due to lack of established systems and processes), and myths surrounding organ donation.
Deborah Verran's insight:
This article provides some insights into the barriers to heart transplantation in India
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Dutch Bill Would Make Everyone an Organ Donor Unless They Opt Out

Dutch Bill Would Make Everyone an Organ Donor Unless They Opt Out | Organ Donation & Transplant Matters Resources | Scoop.it

Dutch lawmakers have taken a step forward on a "yes unless" (opt out) system of organ donation in that country, hoping to make more organs available for transplant.


The first stage of passing the legislation has now occurred following a close vote in the lower house of the Netherlands parliament.


Now it remains to be seen as to whether the legislation passes the upper house.

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Study retraction reignites concern over China’s possible use of prisoner organs

Study retraction reignites concern over China’s possible use of prisoner organs | Organ Donation & Transplant Matters Resources | Scoop.it

The authors of liver transplant outcomes study were unable to  satisfy a journal editor (Liver International) that organs were not from obtained from executed prisoners in China.


Hence the article in question has now been retracted.


It is essential that the sources of organs that are used for the purpose of transplantation are able to be verified in order to meet agreed upon standards for the publication of scientific manuscripts.

Deborah Verran's insight:
It is essential that there be openness and transparency with respect to the reporting of data on both organ donation as well as organ transplantation activities around the world.
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Desde hoy, todos los colombianos serán donantes de órganos - New Opt out system for organ donation in Colombia

Desde hoy, todos los colombianos serán donantes de órganos - New Opt out system for organ donation in Colombia | Organ Donation & Transplant Matters Resources | Scoop.it

En Colombia hay cerca de 2.600 pacientes en lista de espera de órganos. Por eso, para Alejandra Martín, promotora en la donación de órganos en Santander, la ley que comenzará a regir mañana, que declara a todos los colombianos donantes es una noticia de vida para miles. "He visto morir a tantas personas en la lista de espera que quisiera devolver el tiempo para haber comenzado antes a promover la donación”, relata.


This media release from Colombia confirms that as from today Colombia now has an opt out system for organ donation in place. Hence all potential organ donors who are medically suitable will proceed unless they have formally registered a 'No' whilst they were alive. According to the article for individuals who wish to register a No this involves making a formal statement with a notary, whilst they are alive. These statements will then be registered with the National Health Institute.


This reflects the culmination of a 6 month implementation period following the sanctioning of Law 1805 of 2016 by President Juan Manuel Santos in August 2016-

http://confidencialcolombia.com/es/1/actualidad/28986/Desde-hoy-sus-%C3%B3rganos-ser%C3%A1n-del-Estado-tras-la-muerte-Noticias-Confidencial-Colombia-donaci%C3%B3n-de-%C3%B3rganos-ley-de-donaci%C3%B3n-obligatorio.htm?platform=hootsuite


Deborah Verran's insight:
It appears that Colombia now has an opt out system for organ donation in place
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Russia’s Shumakov center boasts record number of heart transplantations in 2016

Russia’s Shumakov center boasts record number of heart transplantations in 2016 | Organ Donation & Transplant Matters Resources | Scoop.it

In a brief report from MOSCOW, via the TASS news organization, it is confirmed that  Russia’s Shumakov Center of Transplantology and Artificial Organs performed 132 heart transplant operations last year. This makes this center an absolute leader in this sector, the Russian Healthcare Ministry said on its official website on Tuesday.


No other details are available at this point in time.

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Surgical Assistant Part of World's 1st Heart Transplant To Be Honored in SA

Surgical Assistant Part of World's 1st Heart Transplant To Be Honored in SA | Organ Donation & Transplant Matters Resources | Scoop.it
The city of Cape Town is set to honor Hamilton Naki, a Black South African surgical assistant involved in the world’s first heart transplant operation.

Although Hamilton had not undergone any formal surgical training, his skills were recognised by heart surgeon Christiaan Barnard. Hence Hamilton came to be an important member of the team that was carrying out some of the ground breaking research during this period in time.

For more on the story click on the banner headline.
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You are an organ donor in France from January 1 2017, if you do not register to opt out

You are an organ donor in France from January 1 2017, if you do not register to opt out | Organ Donation & Transplant Matters Resources | Scoop.it

In news from France comes the confirmation that an opt out system for organ donation has now been implemented effective January the 1st 2017. 


People will now be allowed to express their refusal for organ donation after their death by using the refusal register which has now been established.


Some of the background context for this change, (including statistics for the numbers of organ donors along with the numbers on transplant waiting lists in recent years), can be found in the following article from Le Monde -


http://www.lemonde.fr/les-decodeurs/article/2016/12/22/don-d-organe-quarante-ans-apres-la-loi-sur-le-consentement-presume-ou-en-est-on_5053129_4355770.html


For more information from the French Agency of Biomedicine Dondorganes subsite for organ donation click on the following link-

http://www.dondorganes.fr/

Deborah Verran's insight:
This latest development represents the culmination of the passing of the relevant legislation for opt out for organ donation by the French government in recent years.
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Pioneering surgeons recall first triple transplant operation - BBC News

Pioneering surgeons recall first triple transplant operation - BBC News | Organ Donation & Transplant Matters Resources | Scoop.it
The two surgeons who 30 years ago carried out the world's first heart, lung and liver transplant reflect on their "extraordinary" achievement.

The surgery was undertaken at the Papworth hospital in the United Kingdom and involved two surgical teams headed by Roy Calne and John Wallwork.

At the time this was groundbreaking surgery and was undertaken as the woman (pictured) was going to die without the transplant.

The article contains a lot more information on the chain of events both prior to and following the triple organ transplant procedure.
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ORGAN India and NOTTO Host First Collaborative Conclave for Organ Donation.

ORGAN India and NOTTO Host First Collaborative Conclave for Organ Donation. | Organ Donation & Transplant Matters Resources | Scoop.it

ORGAN India, an initiative of the Parashar Foundation organized a Collaborative Conclave for Organ Donation on 1st December, 2016 at India International Centre, New Delhi, along with NOTTO (National Organ & Tissue Transplant Organisation). Pictured is the team from Organ India.


For the full story click on the following link-

http://www.pocketnewsalert.com/2016/12/ORGAN-India-and-NOTTO-Host-First-Collaborative-Conclave-for-Organ-Donation.html



Via newsattitude
Deborah Verran's insight:
Important development in India, the first ever collaborative for organ donation
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Dr. Denton Cooley, famed Houston heart surgeon, dead at 96

Dr. Denton Cooley, famed Houston heart surgeon, dead at 96 | Organ Donation & Transplant Matters Resources | Scoop.it

Dr. Denton Arthur Cooley, who achieved fame for pioneering surgeries that made worldwide headlines and helped raise the profile of Houston's Texas Medical Center, has died. He was 96. 


During a career which at times was tumultuous Dr Cooley was responsible for some of the pioneering cardiac surgical procedures undertaken in Houston. This includes implanting the first artificial heart as well as performing the first heart transplant. Dr Cooley also helped establish the Texas Heart Institute. His rivalry with another famous cardiac surgeon DeBakey was well documented and is alluded to in this story which makes for fascinating reading.
 

Deborah Verran's insight:
A larger than life individual who pushed the margins in the early days of heart transplantation in the US
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U.S. Centers for Medicare and Medicaid Services report on St. Joseph's Hospital Syracuse New York

U.S. Centers for Medicare and Medicaid Services report on St. Joseph's Hospital Syracuse New York | Organ Donation & Transplant Matters Resources | Scoop.it

This is the full CMS report on St. Joseph Hospital's handling of patient Colleen Burns.


Back in time this patients was taken to the operating room for organ recovery according to the donation after circulatory death pathway. However when the patients showed signs of 'waking up' in the anaesthetic bay organ donation was immediately abandoned.


Despite a preliminary internal investigation revealing no concerns, the external investigation undertaken by CMS  revealed that there were a number of issues.


As a result a number of recommendations were made plus the hospital was fined. The full report can be accessed by clicking on the banner headline.

Deborah Verran's insight:
Failures of communication, documentation and adherence to established protocols can be costly within hospitals. This document should be on the reading list of all professionals involved in organ donation.
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New Dutch organ donation drive results in massive 'no' vote - DutchNews.nl

New Dutch organ donation drive results in massive 'no' vote - DutchNews.nl | Organ Donation & Transplant Matters Resources | Scoop.it

Recently the first step was taken towards altering the current legislation pertaining to organ donation in the Netherlands. As a result of a close vote held within the Dutch parliament the initial groundwork for implementing an opt out system for organ donation has now been taken.


Now it appears that this particular result has stimulated action being taken by a number of people in the community. The response has been a sudden increase in the number of individuals registering that they do not wish to be an organ donor on the national registry.

Deborah Verran's insight:
It may well be that the planned move to enacting opt out legislation for organ donation in The Netherlands does not in fact have widespread support within the community. It remains to be seen how this will now be addressed.
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Organovo to Test "Patches” for Patients Awaiting Liver Transplants | Xconomy

Organovo to Test "Patches” for Patients Awaiting Liver Transplants | Xconomy | Organ Donation & Transplant Matters Resources | Scoop.it
San Diego-based biotech company Organovo has released a statement this last week that it plans to use its 3D bio-printing technology to produce living human liver tissue “patches” that can be ultimately used to treat patients with liver disease.

However as the article goes on to explain, there is a big difference between the bio-printing pf small parcels of liver tissue (as seen in the above image) and the bio-printing of a fully functional human liver. The technology as well as the know how to 3D print a complete human liver is felt to be at least a decade away at this stage.

In addition also in the bioengineering technology front has come the announcement that researchers are looking into developing a bioreactor which could be ultimately used to store human lungs outside of the body (ex-vivo) for up to 24 hours. This story can be viewed via the following link-



Deborah Verran's insight:
Despite the steady stream of news stories about 3D printing and bioprinting, the ability to manufacture whole organs for the purposes of transplantation remains a distant goal.
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Head transplant team’s new animal tests fail to convince critics

Head transplant team’s new animal tests fail to convince critics | Organ Donation & Transplant Matters Resources | Scoop.it

The latest report of research performed on animals in preparation for the first possible so called head transplant has not convinced critics of the procedure. A dog has reportedly recovered the ability to walk after an injection into its damaged spinal cord, but some have criticized the standard of the study as outlined in this online report.


Although there are plans for the first head transplant to be performed in China in 2017, concerns continue to be expressed around both the safety and efficacy of the procedure. Of note the patient will actually undergo a body transplant, that is their body will be replaced.


There are significant barriers to this procedure being successful in practice, of which 5 are identified in this online article posted via Business Insider-

http://www.businessinsider.com.au/italian-surgeon-head-transplant-dog-experiment-2016-9?r=UK&IR=T




Deborah Verran's insight:
The latest news on the so called head transplant which may be performed in China in 2017
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Paolo Macchiarini: A surgeon’s downfall - BBC News

Paolo Macchiarini: A surgeon’s downfall - BBC News | Organ Donation & Transplant Matters Resources | Scoop.it

Ground-breaking work on synthetic tissue transplants made Paolo Macchiarini one of the most famous doctors in the world. Now his reputation lies in tatters.


This is the most comprehensive online article to date on this matter. It provides a summary on the chain of events which ultimately led to an external investigation of the research carried out at the Karolinska Institute in Sweden into trachea transplantation.


For anyone with an interest in the governance of organ and tissue transplantation this is a must read.

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