Organ Donation & Transplant Matters Resources
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Organ Donation & Transplant Matters Resources
Combining reports, research findings and topic reviews
Curated by Deborah Verran
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One doctor's war against global organ trafficking

One doctor's war against global organ trafficking | Organ Donation & Transplant Matters Resources | Scoop.it

Dr. Francis Delmonico, a Harvard Medical School professor, has spent more than a decade leading the fight to establish global ethics principles that govern how human organs are obtained and transplanted.


Read about his involvement in some of the international efforts to try and put a stop to various illicit organ donation and transplantation practices around the world including but not limited to China.


Deborah Verran's insight:
This article will be of particular interest to policy makers as well as healthcare professional involved in either organ donation or transplantation
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The truth about organ transport and transplantation in India

The truth about organ transport and transplantation in India | Organ Donation & Transplant Matters Resources | Scoop.it

There continues to be unmet challenges with respect to increasing the numbers of both organ donors as well as organ transplants in India. With there having been only 350 heart transplants conducted in the last 24 years in the country, there is room for improvement.


The current barriers to increasing the number of organ transplants includes the lack of established transplant units, lack of access due to financial restrictions for many patients and a lack of established transport systems ensuring the rapid delivery of organs between hospitals.


This article will be of interest to healthcare professionals who have an interest in organ donation as well as transplantation.

Deborah Verran's insight:
Increasing the numbers of organ donors as well as the numbers of organ transplants in India will require that concentrated efforts are made to deal with the current barriers.
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Paolo Macchiarini: A surgeon’s downfall - BBC News

Paolo Macchiarini: A surgeon’s downfall - BBC News | Organ Donation & Transplant Matters Resources | Scoop.it

Ground-breaking work on synthetic tissue transplants made Paolo Macchiarini one of the most famous doctors in the world. Now his reputation lies in tatters.


This is the most comprehensive online article to date on this matter. It provides a summary on the chain of events which ultimately led to an external investigation of the research carried out at the Karolinska Institute in Sweden into trachea transplantation.


For anyone with an interest in the governance of organ and tissue transplantation this is a must read.

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How Snapchat is recruiting bone marrow donors

How Snapchat is recruiting bone marrow donors | Organ Donation & Transplant Matters Resources | Scoop.it
A nonprofit organization is now utilizing the Snapchat social media platform in order to reach millennials and help find bone marrow donors for blood cancer patients.

This innovative approach to expanding the potential pool of bone marrow donors has been implemented by Be the Match. More information  on their campaign can be accessed via the following link-


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New Bio-Sensors May Save Lung Transplant Patients from Organ Failure

New Bio-Sensors May Save Lung Transplant Patients from Organ Failure | Organ Donation & Transplant Matters Resources | Scoop.it

In the future a new system of sub classifying donor lungs, based on molecular profiling, could make more donor lungs available for transplantation purposes. 

 

This report is of new research on using a molecular probe in order to detect whether donor lungs may be at risk of poor early function following transplantation .

 

This is the first step in the use of this very modern technology in order to provide this particular type of extra information which can be used to assist with making decisions on whether donor lungs are suitable for transplantation. In addition the information may also be used to subclassify the donor lungs into whether they are considered normal or high risk organs for initial poor graft function following transplantation. More on this story can be viewed by clicking on the banner headline

Deborah Verran's insight:

This new molecular probe type of technology will need to be subjected to further trials so that a clearer picture can be gained of both its accuracy and validity 

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Regenerative Medicine - JAMA: The Journal of the American Medical Association

Regenerative Medicine - JAMA:  The Journal of the American Medical Association | Organ Donation & Transplant Matters Resources | Scoop.it

This Viewpoint describes how regenerative medicine through advances in cell biology, biomaterial science, and biological molecule discovery can replace or regenerate human cells, tissues, and organs harmed by disease or injury. However the full replacement of solid organs remains at this stage a vision, with many barriers needing to be overcome via ongoing laboratory research.

 

The first page of the article can be viewed by clicking on the banner headline. The full article requires access to a subscription to JAMA or can be purchsed online

Deborah Verran's insight:

This is one of a steady stream of review articles appearing regularly in the scientific literature on this relatively new area in medicine.

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Some hospitals in Bulgaria now have reasonable rates of organ donation

Some hospitals in Bulgaria now have reasonable rates of organ donation | Organ Donation & Transplant Matters Resources | Scoop.it

Dr Mariyana Simeonova, head of the Executive Agency for Transplantation in Bulgaria, recently held in an interview with the FOCUS News Agency.

 

Dr Simeonova outlined some of the current statistics for organ transplantation  in Bulgaria as well as the challenges with respect to increasing the rates of organ donation. In addition the top three hospitals for organ transplantation were also named.

Deborah Verran's insight:

Some interesting information from one of the Eastern European countries.

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ISHLT Announces Latest Results of both the NOVEL and the INSPIRE Lung Trials of EVLP

ISHLT Announces Latest Results of both the NOVEL and the INSPIRE Lung Trials of EVLP | Organ Donation & Transplant Matters Resources | Scoop.it

Two clinical research updates have been announced at the 2014 ISHLT meeting. Both involve the use of ex-vivo lung preservation technology. The Results of the NOVEL Lung Trial Show Great Promise at this stage and more info can be obtained by clicking on the banner headline.

 

The results of the INSPIRE Lung Trial can be accessed by clicking on the following link-

http://www.prweb.com/releases/2014/04/prweb11720765.htm

 

Deborah Verran's insight:

Early stages of understanding the place of ex-vivo lung preservation as an option for both managing and evaluating deceased donor lungs prior to transplantation

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ASTS Applauds House Passage of HOPE Act

ASTS Applauds House Passage of HOPE Act | Organ Donation & Transplant Matters Resources | Scoop.it
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The American Society of Transplant Surgeons(ASTS), applauds the passage of the HOPE Act which has now been signed into Law by President Obama. Pictured with President Obama is Dr Peter Stock the current President elect of the ASTS.

 

The passage of this important legislation now permits the transplantation of HIV positive infected organs into recipients. This change to legislation has come on the back of sustained efforts and advocacy by professional organ donation and transplant societies within the United States

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Tissue engineering: How to build a heart - Nature.com

Tissue engineering: How to build a heart - Nature.com | Organ Donation & Transplant Matters Resources | Scoop.it

An update on the status of Tissue engineering titled: How to build a heart is published online via Nature.com

 

The heart is the third most needed organ after the kidney and the liver, with a waiting list of about 3,500 in the United States alone, but it poses extra specific challenges for transplantation. The research into bio-engineering a heart in the laboratory is still at a very early stage as outlined in the article...

Deborah Verran's insight:

A very good update as to where organ and tissue engineering has currently got to

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Bioethics Forum blog - Can Social Media Increase Transplant Donation and Save Lives?

Bioethics Forum blog - Can Social Media Increase Transplant Donation and Save Lives? | Organ Donation & Transplant Matters Resources | Scoop.it

Can the Facebook initiative increase rates of organ donation? Written commentary on this topic complete with statistics comes via the Bioethics Forum a blog publishing thoughts, from a range of perspectives, in bioethics.

 

For the Facebook initiative to be sustained -that is for there to be ongoing steady rates of registration- does now appear to require further action, some suggestions for which are made in the article.

 

This is a free publication of The Hastings Center based in the United States. Access to the blog is via the banner headline.....

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Welcome to Organ Donation & Transplant Matters Resources: ODTMR

Welcome to Organ Donation & Transplant Matters Resources: ODTMR | Organ Donation & Transplant Matters Resources | Scoop.it

This is to announce the arrival of this new web resource http://scoop.it/t/organ-donation-transplant-matters-resources which is now the partner to the established Organ Donation and Transplant Matters (ODTM), http://scoop.it/t/organ-donation-transplant-matters .

 

This ever evolving web based source for information will focus predominantly on the factual, scientific basis of organ donation and transplantation-i.e. the published reports, reviews and research. The partner ODTM web resource will focus more on interesting news plus developments in advocacy in the same areas. The aim is to evolve the two sites to becoming complementary i.e. 'the bricks versus mortar approach'

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Not enough donors, surgeons or teams for organ transplants in Malaysia

Not enough donors, surgeons or teams for organ transplants in Malaysia | Organ Donation & Transplant Matters Resources | Scoop.it

Malaysia is in critical need of more organ transplant surgeons but even if there were more available, there continues to be a lack of surgical teams to retrieve the organs from deceased donors.


This online article makes the point that until now deceased donor organ donation within Malaysia has been an infrequent activity which turns on the ability to mobilise surgical teams made up of individuals whose primary roles within the healthcare sector involve other non related activities.


Hence the absence of dedicated surgeons, along with the lack of additional requisite infra-structure including intensive care unit beds and operating room capacity are now seen to be an issue. Hence for both organ donation and organ transplantation to increase within Malaysia addressing these specific issues is now essential.



Deborah Verran's insight:
Both organ donation as well as organ transplantation require adequate resourcing. This includes resources be diverted specifically towards the requisite infra structure along with having the professionals who are required in order to facilitate this particular activity
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ORGAN India and NOTTO Host First Collaborative Conclave for Organ Donation.

ORGAN India and NOTTO Host First Collaborative Conclave for Organ Donation. | Organ Donation & Transplant Matters Resources | Scoop.it

ORGAN India, an initiative of the Parashar Foundation organized a Collaborative Conclave for Organ Donation on 1st December, 2016 at India International Centre, New Delhi, along with NOTTO (National Organ & Tissue Transplant Organisation). Pictured is the team from Organ India.


For the full story click on the following link-

http://www.pocketnewsalert.com/2016/12/ORGAN-India-and-NOTTO-Host-First-Collaborative-Conclave-for-Organ-Donation.html



Via newsattitude
Deborah Verran's insight:
Important development in India, the first ever collaborative for organ donation
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Iran’s cash-for-kidney programme not without controversy

Iran’s cash-for-kidney programme not without controversy | Organ Donation & Transplant Matters Resources | Scoop.it

Iran’s kidney  transplant programme stands apart from other organ donation systems around the world by openly allowing payments, typically of several thousand dollars to live kidney donors.


Although there is some oversight of the relevant processes including at the level of the hospitals, where this particular programme attracts international concern is whether the financial payment acts as an inducement to live kidney donors.


For more on this story click on the banner headline.

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A patient has 'caught' a kiwi fruit allergy from a bone marrow transplant

A patient has 'caught' a kiwi fruit allergy from a bone marrow transplant | Organ Donation & Transplant Matters Resources | Scoop.it
This is the first proof that this particular type of transplant procedure can lead to the spread of specific food allergies from the donor to the recipient. The fact that the allergy developed in the recipient reflects transmission of the cells responsible for the immune response that underpins the particular allergy in question.

Similar cases have been reported on occasion in liver transplant recipients.
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Surgeon describes first skull and scalp transplant, Newshour - BBC World Service

Surgeon describes first skull and scalp transplant, Newshour - BBC World Service | Organ Donation & Transplant Matters Resources | Scoop.it

Surgeon Michael Klebuc describes the operation that was required to replace Jim Boysen's skull and scalp.

 

Dr Klebuc also describes the challenges with sourcing the appropriate size matched and colour matched composite tissue graft that was used to partially replace this patients own skull and scalp. The audio can be accessed via clicking on the banner headline.

 

A more detailed online report of the planning that was required as well as the conduct of the surgery and the aftercare of this patient can be accessed via the following link-

http://www.washingtonpost.com/news/morning-mix/wp/2015/06/05/texas-man-gets-worlds-first-skull-and-scalp-transplant-plus-a-new-kidney-and-pancreas/

 

Deborah Verran's insight:

This patient underwent both a composite tissue transplant as well as a combined kidney-pancreas solid organ transplant. This required the co-operation of multiple surgical teams as well as rigorous attention to both planning and undertaking the surgical procedure.

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Top marks for organ donation in Scotland

Top marks for organ donation in Scotland | Organ Donation & Transplant Matters Resources | Scoop.it

The latest Report card from Scotland reveals that there has been significant increase in the rates of organ donation and transplantation in recent years.

 

The full media release can be accessed via the following link-

http://news.scotland.gov.uk/News/Top-marks-for-organ-donation-in-Scotland-1255.aspx

 

 

 

Deborah Verran's insight:

Good news from Scotland

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NIH-funded researchers extend liver preservation for transplantation - EurekAlert (press release)

NIH-funded researchers extend liver preservation for transplantation - EurekAlert (press release) | Organ Donation & Transplant Matters Resources | Scoop.it

Reported online via EurekAlert is the news that NIH-funded researchers in the United States may have developed a new method for extending liver preservation for transplantation.

 

Transplants of skin, kidneys, hearts, lungs, corneas, and livers have become commonplace but due to a shortage of donor organs not all potential transplant recipients will receive a transplant in time.

 

Rat livers where able to be preserved for an extended period of time using a new super cooling method which is described in more detail in the report(click on banner headline).

 

For a more detailed report click on the following link to the NIH press release-

 

http://www.nih.gov/news/health/jun2014/nibib-30.htm

 

Deborah Verran's insight:

More research is now required to see whether this new process can be adapted for the cold preservation of human livers to allow for extended periods of storage prior to transplantation

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Global Observatory on Donation & Transplantation (GODT)

Global Observatory on Donation & Transplantation (GODT) | Organ Donation & Transplant Matters Resources | Scoop.it

Overseen by the World Health Organization and ONT in Spain is the Global Observatory on Donation and Transplantation.

 

For data on global organ donation rates as well as as the rates of solid organ transplantation click on the banner headline. To access slides from the most recent annual report click on the graphic (pictured) on the GODT home page

Deborah Verran's insight:

Accurate, reliable data presented via graphics which allow for a ready comparison of both the rates of organ donation and organ transplantation

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Taking Organ Transplantation to 2020.

Taking Organ Transplantation to 2020. | Organ Donation & Transplant Matters Resources | Scoop.it

Announced via the NHSBT in the United Kingdom, a new strategy for organ donation and transplantation - Taking Organ Transplantation to 2020.

 

Documents can be accessed via the web page by clicking on the banner headline.

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Nature | News Miniature human liver grown in mice - Nature.com

Nature | News Miniature human liver grown in mice - Nature.com | Organ Donation & Transplant Matters Resources | Scoop.it

Reported via the science journal Nature,  news that miniature human liver buds have been grown in mice

This article has attracted a lot of attention, however this is a proof of concept study and as noted in the article 'the transplanted animals need to be observed for several more months to see whether the cells begin to degenerate or form tumours'.

 

As reported via The Guardian, there is hope in the future that this type of research will eventually lead to treatments that will help alleviate the requirement for livers from organ donors-

 

http://www.guardian.co.uk/science/2013/jul/03/human-liver-stem-cell-treatment

Deborah Verran's insight:

This research only solves one piece of the complex puzzle of 'growing' organs in the laboratory. Hence in the short to medium term, liver transplantation will require that the organs are sourced from organ donors.

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UNOS | Donation & Transplantation | Patient Education | Patient Brochures

UNOS | Donation & Transplantation | Patient Education | Patient Brochures | Organ Donation & Transplant Matters Resources | Scoop.it

An example of patient information brochures from the United States on organ donation and transplantation.

 

The United Network for Organ Sharing (UNOS) is the private, non-profit organization that manages the U.S. organ transplant system under contract with the federal government.

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New book highlights shortage of organ donors - beds.ac.uk

New book highlights shortage of organ donors - beds.ac.uk | Organ Donation & Transplant Matters Resources | Scoop.it

Have an interest in policy underpinning organ donation and transplantation? Looking for a written resource containing interesting information?

 

Organ Donation and Transplantation - Public Policy and Clinical Perspectives, is packed with expert chapters and has just been released as an e-Book in the United Kingdom. It provides specialist information via chapters on public policy as well as clinical developments in organ transplantation.

 

The link to the eBook is- http://www.intechweb.org/books/show/title/organ-donation-and-transplantation-public-policy-and-clinical-perspectives

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