Organ Donation & Transplant Matters Resources
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Organ Donation & Transplant Matters Resources
Combining reports, research findings and topic reviews
Curated by Deborah Verran
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Nobel Prize judges fired in scandal surrounding trachea transplant surgeon

Nobel Prize judges fired in scandal surrounding trachea transplant surgeon | Organ Donation & Transplant Matters Resources | Scoop.it
Two members of the group that awards the Nobel Prize in Physiology for Medicine at Sweden’s Karolinska Institute have now been asked to resign over their involvement in a scandal over the work of now disgraced surgeon Dr Paolo Macchiarini.

This latest development follows the release of an external review into the trachea transplant programme. It seems that important red flags were either not acted upon or were ignored.

For another online media report from Sweden click on the following link-


Deborah Verran's insight:
The latest development following an external review of the trachea transplant programme at the Karolinska Institute in Sweden
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Woman gives birth to a live infant after uterus transplant, in a medical first

Woman gives birth to a live infant after uterus transplant, in a medical first | Organ Donation & Transplant Matters Resources | Scoop.it

 

A healthy baby boy has been born born prematurely via caesarean section to a Swedish mother last month after the mother had undergone a successful uterus transplant. The uterus was donated from a 61-year-old friend of the mother.

 

This case now represents proof of concept that a live birth can follow a successful uterus transplant, which to date has proven difficult to achieve in other cases.

 

The medical team from Sweden (some of whom are pictured above undertaking the transplant surgery) have also reported the case in detail in a leading medical journal The Lancet. The full Lancet paper can be downloaded via-

 

http://download.thelancet.com/flatcontentassets/pdfs/S0140673614617281.pdf

 

 

An image of the baby along with some condensed information can be viewed via clicking on the following link-

http://www.telegraph.co.uk/health/healthnews/11140527/Womb-transplant-first-picture-of-baby-born-after-pioneering-operation.html?__scoop_post=2bc97550-4bbe-11e4-9fb1-001018304b75&__scoop_topic=416336#__scoop_post=2bc97550-4bbe-11e4-9fb1-001018304b75&__scoop_topic=416336

 

 

 

Deborah Verran's insight:

This case represents the culmination of the efforts of clinical research programme into uterus transplantation in Sweden. Of note the indications for the procedure may remain limited due to the nature of the surgery required, the ability to source an appropriate donor organ and the requirement for close medical monitoring of the recipient.

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TransMedics keeps donor hearts beating en route to transplant patients - Al Jazeera America (blog)

TransMedics keeps donor hearts beating en route to transplant patients - Al Jazeera America (blog) | Organ Donation & Transplant Matters Resources | Scoop.it

The new TransMedics OCS device keeps donor hearts beating en route to transplant patients

"A human organ has never been kept alive outside of a human body until this machine became a clinical reality,"

 

For a description of this new technology, along with images as well as video footage from the University of California Los Angeles heart transplant programme, click on the banner headline.

Deborah Verran's insight:

This new technology may also allow for the transport of donated hearts across wider geographic regions than is possible currently.

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Advising Potential Recipients on the Use of Organs From Donors with CNS Tumours: Transplantation

All potential organ donors are carefully assessed as to whether they are 'medically suitable' to proceed to donate. Are you aware that this includes checking for a history of malignancy(cancer) in the donor and then deciding on whether there is a risk of tumour transmission to the transplant recipients?

 

Deciding to use an organ from a donor for example with a primary central nervous system (CNS) tumor, necessitates a discussion with the potential recipient about the risk of tumour transmission(versus the risk of waiting for another organ offer). Balancing risks is a major consideration.

 

This article, is based on an analysis of outcome data from the United Kingdom of using organs for transplantation from donors with cerebral tumours. The article adds to the knowledge base which transplant programs use to help guide decisions on whether to accept donor organs for transplant or not. 

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Kidneys for sale: Iran’s trade in organs

Kidneys for sale: Iran’s trade in organs | Organ Donation & Transplant Matters Resources | Scoop.it

Iran is the only country in the world where it is legal to sell a kidney. Donors get money from the buyer and from the state, a system which eradicated waiting lists but, detractors say, now exploits the poor and vulnerable. Here, we follow one terrible story.

 

To read the full story click on the banner headline. There is also a photo library of images available for viewing which relate to the story.

Deborah Verran's insight:

This article exposes the harsh reality of a poor family selling virtually everything they have in order to 'buy' a live donor kidney for their son. This story does not have a happy ending.

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'Mini-kidney' structures generated from human stem cells for first time

'Mini-kidney' structures generated from human stem cells for first time | Organ Donation & Transplant Matters Resources | Scoop.it

Diseases affecting the kidneys represent a major and unsolved health issue worldwide. The kidneys rarely recover function once they are damaged by disease, highlighting the urgent need for better knowledge of kidney development and physiology.

 

Hence the impetus to "grow" or assemble kidneys in the laboratory. This report is of research performed at the Salk institute which has involved the use and manipulation of pulripotent stem cells  to from small 'kidney buds' under laboratory conditions.

Deborah Verran's insight:

This represents the preliminary stages of research which will ultimately need to translate into viable organs that have both adequate and sustained function to ensure successful transplantation into humans. Also important quality and safety issues will need to be met

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Beating new life into a heart transplant - Medical Xpress

Beating new life into a heart transplant - Medical Xpress | Organ Donation & Transplant Matters Resources | Scoop.it

Reported online via Medical Xpress is this article: Beating new life into a heart transplant, which reports on research efforts within the United Kingdom.

 

The aim of this type of research is to explore how donor hearts which would not be medically suitable for transplantation, can then be 're-conditioned'.  This could lead to an increase in the number of donor hearts which are then utilised for transplantation.

 

As Professor James Neuberger, Associate Medical Director at NHS Blood and Transplant said: "Surgeons are very keen to transplant every donated organ that can be transplanted safely...

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