Organ Donation & Transplant Matters Resources
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Organ Donation & Transplant Matters Resources
Combining reports, research findings and topic reviews
Curated by Deborah Verran
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U.S. Centers for Medicare and Medicaid Services report on St. Joseph's Hospital Syracuse New York

U.S. Centers for Medicare and Medicaid Services report on St. Joseph's Hospital Syracuse New York | Organ Donation & Transplant Matters Resources | Scoop.it

This is the full CMS report on St. Joseph Hospital's handling of patient Colleen Burns.


Back in time this patients was taken to the operating room for organ recovery according to the donation after circulatory death pathway. However when the patients showed signs of 'waking up' in the anaesthetic bay organ donation was immediately abandoned.


Despite a preliminary internal investigation revealing no concerns, the external investigation undertaken by CMS  revealed that there were a number of issues.


As a result a number of recommendations were made plus the hospital was fined. The full report can be accessed by clicking on the banner headline.

Deborah Verran's insight:
Failures of communication, documentation and adherence to established protocols can be costly within hospitals. This document should be on the reading list of all professionals involved in organ donation.
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Rabies cases probably linked to kidney donor in China: Study | Outbreak News Today

Rabies cases probably linked to kidney donor in China: Study | Outbreak News Today | Organ Donation & Transplant Matters Resources | Scoop.it
It appears that two renal transplant recipients have been diagnosed with rabies which appears to have been transmitted by a deceased donor in Southern China.

More on the case can be viewed via this link  - https://t.co/qtRj4wyksm
Deborah Verran's insight:
Encephalitis in a potential organ donor can be due to an infectious agent and hence is usually a contraindication to organ donation proceeding.
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Scientists Just 3D Printed a Transplantable Human Ear

Scientists Just 3D Printed a Transplantable Human Ear | Organ Donation & Transplant Matters Resources | Scoop.it

Scientists have developed an innovative 3D bioprinter capable of generating replacement tissue that’s strong enough to withstand transplantation.

 

However there remain limitations as to what type of tissue can be bioprinted and why this continues to be the case.

 

However in this detailed online report an outline is provided as to how a bioprinter was used to help generate the various tissues that were then implanted into animals to see if they remained viable.

 

A video of the ITOP system in action can be viewed via the following link-

https://youtu.be/wFFkBW7acOI

 

Deborah Verran's insight:

Another small step has been achieved as part of the ongoing efforts to try and reliably bio-print human tissues. At this stage the possibility of being able to bio-print human organs for transplantation purposes remains a distant goal.

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Organ transplants decline in number - The Slovak Spectator

Organ transplants decline in number - The Slovak Spectator | Organ Donation & Transplant Matters Resources | Scoop.it

This report outlines how Slovakia has fallen behind neighbouring countries when it comes to the per annum rates of organ donors.

 

Mention is made of what are felt to be some of the possible contributory factors despite the fact that Slovakia has opt out legislation in place. In addition steps are now being taken to come up with possible solutions which may be implemented to help increase the rates of organ donation.

Deborah Verran's insight:

Interesting commentary on the current status of organ donation in Slovakia

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Bionic reconstruction gives men first prosthetic hands controlled by mind

Bionic reconstruction gives men first prosthetic hands controlled by mind | Organ Donation & Transplant Matters Resources | Scoop.it

Three Austrians have had their injured limbs amputated, then nerves and muscles have been transplanted from the leg to the arm in each case so that the patients could learn to control their new prosthetic hands.

 

This is the online report summarizing the results of research that has just been published online in the medical journal The Lancet. This new approach to replacing damaged limbs with a hybrid of the patients own tissues and robotic type technology appears to be extremely promising.

 

A video of the functional results with use of the new bionic arm in practice can be viewed via the link which can be accessed by clicking on the banner headline or via the following link-

http://www.theguardian.com/science/video/2015/feb/25/world-first-bionic-hand-controlled-by-mind-video

 

 

Deborah Verran's insight:

Extraordinary development. This approach avoids the risks associated with life long anti-rejection therapy which is required for patients who may instead undergo arm transplantation.

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Report that Cambodia is now a target for organ trafficking

Report that Cambodia is now a target for organ trafficking | Organ Donation & Transplant Matters Resources | Scoop.it

Reported online via the Japan times the story of a young man who was lured from Cambodia to Thailand in order to sell one of his kidneys.

 

The man is left with a seven-inch scar which runs diagonally across the left flank of his torso, a glaring reminder of an operation he hoped would save his family from debt but instead plunged him into despair.

 

For more on this story click on the banner headline.

Deborah Verran's insight:

Yet another account of organ trafficking

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Nepal's Organ Trail: How traffickers steal kidneys

Nepal's Organ Trail: How traffickers steal kidneys | Organ Donation & Transplant Matters Resources | Scoop.it

Reported online via the CNN Freedom Project. In Nepal, organ traffickers are duping villagers into having operations and taking their kidneys.

 

Click on the banner headline to read more about this story

Deborah Verran's insight:

Yet another example of 'needy' individuals being paid (not a lot of money) to donate one of their kidneys with brokers involved in the transactions. Of most concern is how some of the donors are being coerced into actually going ahead.

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Doctors treating liver patients say decline is quick, permanent - Hawaii News Now

Doctors treating liver patients say decline is quick, permanent - Hawaii News Now | Organ Donation & Transplant Matters Resources | Scoop.it

Report from Hawaii of a number of cases of acute liver failure which have been linked to use of a dietary supplement. The doctors who are treating the patients diagnosed with acute liver failure are quoted as saying that in some of the patients the  decline in liver function is relatively rapid. Plus the liver injury in some of the cases has been both severe  and permanent, requiring liver transplantation.

Doctors at The Queen's Medical Center spoke for the first time about the dietary supplement scare that has injured 32 people to date. The supplement marketed as OxyElitePro is now subject to a Food and Drug Administration Alert within the United States of America.

Deborah Verran's insight:

Concerning report linking an over the counter dietary agent to cases of acute liver failure in Hawaii. In the most serious cases liver transplantation was required in order to rescue the patients.

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Augmentin implicated in drug-induced liver injury - Family Practice News Digital Network

Augmentin implicated in drug-induced liver injury - Family Practice News Digital Network | Organ Donation & Transplant Matters Resources | Scoop.it

From Iceland comes this report of a population based study of drug induced liver injury leading to hospitalisation in adults and reported online via the 
Family Practice News Digital Network.

 
The crude incidence of drug-induced liver injury in this series is roughly 19.1 cases per 100,000 inhabitants, with amoxicillin-clavulanate the most commonly implicated agent.

Deborah Verran's insight:

Extreme cases of drug induced liver injury can lead to acute liver failure and hence the requirement for liver transplantation

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Surgeons in Poland perform first life-saving face transplant on man, 33, who ... - Daily Mail

Surgeons in Poland perform first life-saving face transplant on man, 33, who ... - Daily Mail | Organ Donation & Transplant Matters Resources | Scoop.it

Reported via the Daily Mail in detail, including graphics.

Surgeons in Poland perform the first life-saving face transplant in the country on a man, aged 33, who sustained extensive damage to his face in a work related accident. Due to the seriousness of the injuries the face transplant was performed relatively urgently.

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Study reports liver donors face mortality risk with LDLT - from News-Medical.Net - News-Medical.net

Study reports liver donors face mortality risk with LDLT - from News-Medical.Net - News-Medical.net | Organ Donation & Transplant Matters Resources | Scoop.it

Published Study reports that live liver donors face a mortality risk with LDLT  A study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplant Society has revealed what are the current estimated risks for morbidity and mortality with adult live liver donation...

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Icing Organs | The Scientist Magazine®

Icing Organs | The Scientist Magazine® | Organ Donation & Transplant Matters Resources | Scoop.it

This article explores why scientists are so near and yet so far from being able to cryopreserve organs.

 

This includes an explanation of how cryopreservation works, a summary of the research to date as well as why the anticipated success has not as yet been realised for organ preservation.

 

The majority of organs for transplantation continue to be kept under static cold storage( 4 degrees celsius) conditions. Machine preservation is also being used but is not as yet widespread and is now the subject of ongoing clinical research.

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Positive outcomes in largest liver transplant trial to date - Pharmacy Europe

Positive outcomes in largest liver transplant trial to date - Pharmacy Europe | Organ Donation & Transplant Matters Resources | Scoop.it

This report is on the positive outcomes achieved in the largest liver transplant trial of an immunosuppressive agent to date. New two-year results from the Phase III study in liver transplant recipients with the drug Everolimus in combination with other immunosuppressive agents have confirmed that there was comparable efficacy in the treatment arm to the control arm. Plus superior renal function was seen in the treatment arm during the study period.

 

As a result Everolimus will now become another immunosuppressive agent that may be used in the ongoing management of liver transplant recipients.

 

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Paolo Macchiarini: A surgeon’s downfall - BBC News

Paolo Macchiarini: A surgeon’s downfall - BBC News | Organ Donation & Transplant Matters Resources | Scoop.it

Ground-breaking work on synthetic tissue transplants made Paolo Macchiarini one of the most famous doctors in the world. Now his reputation lies in tatters.


This is the most comprehensive online article to date on this matter. It provides a summary on the chain of events which ultimately led to an external investigation of the research carried out at the Karolinska Institute in Sweden into trachea transplantation.


For anyone with an interest in the governance of organ and tissue transplantation this is a must read.

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Deceased-Donor Age Affects Kidney Transplant Outcomes 

Deceased-Donor Age Affects Kidney Transplant Outcomes  | Organ Donation & Transplant Matters Resources | Scoop.it
In this recently reported analysis of Registry data, recipients of kidneys from individuals who donated the organs after circulatory death are more likely to experience graft loss and delayed graft function. This is particularly the case of the donor was aged over 50 years.

This data adds to the knowledge pertaining to renal allograft outcomes according to the type of donor as well as the age of the donor.
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DCD heart transplant in China: Heart stops beating, revives 7 hours later

This is an online report of a successful heart transplant surgical procedure in east China. A heart transplant in Fujian Province was successful even though the donor organ had stopped beating for a period of time in the donor prior to its retrieval.

 

Although there is limited information in this video, it does seem that the donor heart was retrieved from a DCD donor and then transported to the recipient hospital where it was then transplanted.

Deborah Verran's insight:

This is an indication that heart transplantation from DCD donors is now proceeding in China

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Drugs produce high hepatitis C eradication rates, even in patients with liver disease

Drugs produce high hepatitis C eradication rates, even in patients with liver disease | Organ Donation & Transplant Matters Resources | Scoop.it

This is the latest report of success being achieved with new direct anti-viral drugs in the treatment of hepatitis C.

 

Two clinical trials of antiviral drug combinations report that 12-week courses are leading to effective viral eradication for a high percentage of patients with chronic hepatitis C infection.

 

To read more on the particular drugs involved and what the exact results were please click on the banner headline.

Deborah Verran's insight:

Further evidence of the efficacy of some of the new antiviral agents for treating chronic hepatitis C. It is hoped that eventually there will be less patients requiring liver transplantation for liver disease due to this particular virus.

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Older donors could help reduce organ transplant gap: Canadian Report

Older donors could help reduce organ transplant gap: Canadian Report | Organ Donation & Transplant Matters Resources | Scoop.it

Canada could reduce its persistent shortage of organs for transplant by retrieving more organs from older donors, says a study released Thursday by the Canadian Institute for Health Information. 

 

The variability seen in the rates of organ donation as well as the variation in the demographics of organ donors across the country has led to a closer examination of where the potential exists to increase the rates of organ donation.

 

The report highlights what can be viewed as the current missed opportunities to increase the rates of organ donation across Canada.

 

The link to the full report -

 

http://www.cihi.ca/cihi-ext-portal/internet/en/document/types+of+care/specialized+services/organ+replacements/release_18dec14

 

Deborah Verran's insight:

Variation between the provinces in Canada has led to this closer examination of data pertaining to organ donation. The recommendations are sound and the whole report is worth reading. This will be of interest to professionals who hold the responsibility and/or interest in the performance of health care systems pertaining to organ donation.

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NIH-funded researchers extend liver preservation for transplantation - EurekAlert (press release)

NIH-funded researchers extend liver preservation for transplantation - EurekAlert (press release) | Organ Donation & Transplant Matters Resources | Scoop.it

Reported online via EurekAlert is the news that NIH-funded researchers in the United States may have developed a new method for extending liver preservation for transplantation.

 

Transplants of skin, kidneys, hearts, lungs, corneas, and livers have become commonplace but due to a shortage of donor organs not all potential transplant recipients will receive a transplant in time.

 

Rat livers where able to be preserved for an extended period of time using a new super cooling method which is described in more detail in the report(click on banner headline).

 

For a more detailed report click on the following link to the NIH press release-

 

http://www.nih.gov/news/health/jun2014/nibib-30.htm

 

Deborah Verran's insight:

More research is now required to see whether this new process can be adapted for the cold preservation of human livers to allow for extended periods of storage prior to transplantation

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Kidney transplant patients live longer than those in intensive home hemodialysis - Medical Xpress

Kidney transplant patients live longer than those in intensive home hemodialysis - Medical Xpress | Organ Donation & Transplant Matters Resources | Scoop.it

Analysis of data from a research study performed in Canada has revealed that Kidney transplant patients live longer than those receiving intensive home hemodialysis.

 

A first-ever study from a large Canadian centre has found that kidney

transplant recipients lived longer and had better treatment success regardless of what type of donor kidney that they received. 'Kidney transplant is still the best treatment option says Dr Chris Chan (pictured) who is a nephrologist at the Toronto General Hospital.

 

To read more about the findings of this study, click on the banner headline.

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Could Redistricting Shorten The Wait For A Liver Transplant? - Huffington Post

Could Redistricting Shorten The Wait For A Liver Transplant? - Huffington Post | Organ Donation & Transplant Matters Resources | Scoop.it

Could Redistricting Shorten The Wait For A Liver Transplant?
Reported via the Huffington Post

Where you live can affect your chances of getting a liver transplant, as well as your risk of dying while waiting, if you live in the United States.

 

Analysis of organ donor rates versus time spent waiting for a donor liver have revealed that there is indeed variation across the United States in waiting times for a liver transplant.

 

Why this may be the case and what could be done to try and address this variation is also outlined in the article.

 

 

Deborah Verran's insight:

Interesting article which attempts to address a complex issue

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More Kids Getting Donor Organs, But Gaps Persist, Study Finds ...

More Kids Getting Donor Organs, But Gaps Persist, Study Finds ... | Organ Donation & Transplant Matters Resources | Scoop.it

This is the online news report of a review that has been undertaken the organ donation practices within the United States, that lead to children receiving transplanted organs.

 

By looking at the statistics covering all liver, kidney, heart, lung, pancreas and small bowel donations, the team found that just over 14,200 American children received an organ transplant in the study time frame.

 

Mention is also made of the increasing trend in pediatric DCDD (Donation post Cardiocirculatory Determination of Death) organ donation within the United States.

 

One other online report also describing the research can be viewed via MedPage today-

 

http://www.medpagetoday.com/Transplantation/Transplantation/39247

Deborah Verran's insight:

Interesting article of interest to healthcare professionals involved either in organ donation or in the care for pediatric transplant recipients

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Organ donation: A fight to survive

Organ donation: A fight to survive | Organ Donation & Transplant Matters Resources | Scoop.it

With organ donations in South Africa dipping as low as two per million people many don't live long enough to find a suitable match, writes Faranaaz Parker.

 

This article outlines what may be some of the factors contributing to the current low organ donor rate within South Africa, including culture and beliefs in some sectors of society. Also some of the current initiatives that have been implemented in other countries to increase rates of organ donation are also outlined.

Deborah Verran's insight:

An interesting article from a country with one of the lower rates of organ donation in the world.

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Researchers link facial structure to kidney disease - Medical Xpress - Medical Xpress

Researchers link facial structure to kidney disease - Medical Xpress - Medical Xpress | Organ Donation & Transplant Matters Resources | Scoop.it

Reported via Nature World News & Medical Xpress:
Researchers link facial structure to kidney disease
In Autosomal Dominant Polycystic Kidney Disease (ADPKD) which is the most common genetic kidney disorder, there is now some preliminary evidence that there are subtle differences in facial structure compared to individuals without ADPKD.

 

To read more click on the banner headline.

Deborah Verran's insight:

As some of the genetic disorders which are associated with abnormalities of the kidneys are further characterised, expect more information like this to come to hand

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The silent pandemic: Tackling hepatitis C with policy innovation

The silent pandemic: Tackling hepatitis C with policy innovation | Organ Donation & Transplant Matters Resources | Scoop.it

This report on Hepatitis C has been released via the Economist Intelligence Unit http://www.managementthinking.eiu.com and was sponsored by Janssen.

 

Via the link access can be gained not only to the full report-which can be downloaded- but also to a useful infographic as well as a short factual video.

 

Hepatitis C is a major cause of chronic liver disease globally(evident in the statistics in the report on the incidence per country). This is now creating challenges for both the identification as well as the appropriate management of individuals harbouring the virus. Some examples of innovative strategies that are in the process of being implemented in a number of countries are outlined.

 

With more comprehensive and effective anti-viral regimens now becoming available there are implications for the appropriate treatment of patients. Allowing for the fact that chronic liver disease from hepatitis C is currently the most common indication for liver transplantation in many countries, this report makes for interesting reading.  

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