Organ Donation & Transplant Matters Resources
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Organ Donation & Transplant Matters Resources
Combining reports, research findings and topic reviews
Curated by Deborah Verran
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Lanie Ross - When Altruism Goes Awry: Live Kidney Donors in End Stage Renal Disease

This lecture titled 'When Altruism Goes Awry: Living Kidney Donors in End Stage Renal Disease' was delivered via Lanie Ross, MD, University of Chicago November 13, 2015 

 

It explores what is known about live kidney donors who have gone on to develop end stage renal failure within the United States. It also outlines the current limitations of registry data and how this may be improved.

Deborah Verran's insight:

This talk will be of interest to healthcare professionals with a role in the oversight and management of living kidney donation.

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Pregnancy Outcomes are Similar for Adult and Child Female Kidney Transplant Recipients

Pregnancy Outcomes are Similar for Adult and Child Female Kidney Transplant Recipients | Organ Donation & Transplant Matters Resources | Scoop.it

Pregnancy outcomes are similar for women who have received a kidney transplant, whether they were a child or an adult at the time when they got their transplant, according to a new study published in the February issue of JAMA Pediatrics.

 

These are the conclusions of researchers who analysed data held in the ANZDATA Registry.

Deborah Verran's insight:

Important data which can be used to help guide clinicians in offering advice to women of child bearing age post kidney transplantation

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Transplant 'fairness' at issue for panel, Georgians

Transplant 'fairness' at issue for panel, Georgians | Organ Donation & Transplant Matters Resources | Scoop.it

A committee on liver transplants in the United States has indicated this last weeks that reducing the nation's number of transplant regions — from the current 11 to four (for the purposes of donor liver allocation) — could potentially save hundreds of lives.

 

However as outlined in detail in this article published online, the potential to save lives has to be balanced with utility of donor liver allocation as not all donor livers are of the same quality. This difference in the quality of donor livers currently places constraints on the time period in which they can be transplanted following removal from the donor.

 

The article focuses on the concerns held by surgeons at a transplant programme in Atlanta, Georgia as to how the new scheme would work. To read more on this story click on the banner headline.

Deborah Verran's insight:

In countries with large geographic regions the allocation of donor livers requires a balancing of equity with utility taking into account all of the factors which impact on donor liver utilization.

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Why a Woman's Heart May Be a Bad Fit for a Man - MedPage Today

Why a Woman's Heart May Be a Bad Fit for a Man - MedPage Today | Organ Donation & Transplant Matters Resources | Scoop.it

This report of an analysis of heart transplant outcomes posted online via MedPage Today reveals some interesting results.

 

Although differences in body mass between the donor and the recipient were not predictive of survival after heart transplantation, differences in the predicted heart mass using specific equations were related to survival up to 5 years...

Deborah Verran's insight:

The 'size matching' of donor hearts to recpient body frame rather than recipient body mass index appears to be extremely important based on the data from this research analysis

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Deadly Parasitic Roundworms Transmitted Through Organ Transplants [PHOTOS] - Medical Daily

Deadly Parasitic Roundworms Transmitted Through Organ Transplants [PHOTOS] - Medical Daily | Organ Donation & Transplant Matters Resources | Scoop.it

Reported online via Medical Daily:
Deadly Parasitic Roundworms (Strongyloides stercoralis) Transmitted Through Organ Transplants [complete with graphics and PHOTOS].


The heart recipient, a 59-year-old with weakened heart muscles, came down with a respiratory illness seven weeks after the transplant. To read more on the outcomes of all of the recipients of the donor organs from this one donor, click on the banner headline

Deborah Verran's insight:

An unusual case of disease transmission via organs from one deceased donor with unrecognised parasitic threadworm infection

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Transplants Candidates How Much Does Size Matter

Transplants Candidates How Much Does Size Matter | Organ Donation & Transplant Matters Resources | Scoop.it

Obese individuals often are rejected as renal transplant candidates in large part because of their increased risk for surgical complications and adverse outcomes.

 

This article via Renal and Urology News summarises some of the evidence to date. This includes making the point that abdominal girth may be more important in determining candidacy for renal transplantation over and above body mass index(BMI). Other medical co-morbities associated with obesity also mandate that extra attention be specifically paid to the effects of diabetes and vascular disease on potential transplant recipients.

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Facebook and organ donor status – Interesting discussion via k8lin.com

Facebook and organ donor status – Interesting discussion via k8lin.com | Organ Donation & Transplant Matters Resources | Scoop.it

Will the Facebook organ donation initiative actually lead to an actual increase in the dnor rate? What is the evidence to support this initiative leading to a sustained alteration in the rates of organ donation?

 

This interesting blog post about Facebook and organ donation has been sourced via Twitter from @k8lin http://t.co/UAkS51i7.......... If you have links to the organ donation sector this may be of interest.

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Researchers achieving improved outcomes with Pig-to-Primate Organ Transplants - MIT Technology Review

Researchers achieving improved outcomes with Pig-to-Primate Organ Transplants - MIT Technology Review | Organ Donation & Transplant Matters Resources | Scoop.it

A biotech company’s genetically engineered pigs are now setting new records for outcomes as the result of xenotransplantation of some of the organs into primates.

 

It appears that years of laboratory research are now beginning to deliver promising results with the use of these particular animal organs for transplantation purposes. It may be possible that if the results continue to improve that trials in humans may be contemplated in the not too distant future.

Deborah Verran's insight:

Good summary of the current status of xenotransplantation. The full article can be accessed by clicking on the banner headline.

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Frailty Tied to Lower Survival Rates After Kidney Transplant

Frailty Tied to Lower Survival Rates After Kidney Transplant | Organ Donation & Transplant Matters Resources | Scoop.it

Research findings have linked increased patient frailty at the time of kidney transplant surgery to an increased mortality rate. This has recently been published online in the American Journal of Transplantation which can be viewed via the following link-

http://au.wiley.com/WileyCDA/PressRelease/pressReleaseId-113402.html

 

 It is suggested by the researchers that doctors should monitor such patients closely after surgery.

Deborah Verran's insight:

At times decisions also have to be made to not proceed with kidney transplant surgery if patients are significantly physically deconditioned. Kidney transplant surgery is major surgery and is combined with the initiation of powerful immunosuppressive drug therapy. This sets this type of surgery apart from operations of a similar magnitude.

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Long-term Survival Possible for Pediatric Heart Transplant Patients - Newswise (press release)

Long-term Survival Possible for Pediatric Heart Transplant Patients - Newswise (press release) | Organ Donation & Transplant Matters Resources | Scoop.it

Via the Society of Thoracic Surgeons comes these two press releases on the long term outcomes of heart transplantation. 

 

In one study Hannah Copeland, MD and colleagues from Loma Linda University in Loma Linda, CA, reviewed the medical charts of 337 pediatric heart transplant recipients. To read more click on the banner headline.

 

The second press release on the long term outcomes of adult heart transplant recipients can be viewed by clicking on the following link-

http://www.newswise.com/articles/heart-transplant-success-improving-patients-living-longer?ret=/articles/list&category=medicine&page=1&search%5Bstatus%5D=3&search%5Bsort%5D=date+desc&search%5Bsection%5D=10&search%5Bhas_multimedia%5D=

 

Deborah Verran's insight:

The outcomes following heart transplantation continue to improve with many patients now surviving up to 20 years following the procedure.

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Transplant Patient Outcomes After Trauma Better Than Expected - Science Daily (press release)

Transplant Patient Outcomes After Trauma Better Than Expected - Science Daily (press release) | Organ Donation & Transplant Matters Resources | Scoop.it

News that Transplant Patient Outcomes After Trauma are Better Than Expected as reported via Science Daily (press release). This follows the publication of a clinical report in the Journal of Trauma & Acute Care Surgery (June 2013). 

 

Trauma teams should be encouraged that patients with prior organ transplants do not do worse after injury, and that the transplanted organ (also known as an allograft) often is not directly involved.

 

However there may be an increased incidence of acute rejection following the episode of trauma which has implications for the management of immunosuppressive medications.

Deborah Verran's insight:

This report will be of interest to healthcare professionals in both the acute care sector as well as the transplant sector

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Older Circulatory-Death Donor Kidneys Acceptable for Transplant - Renal and Urology News

Older Circulatory-Death Donor Kidneys Acceptable for Transplant - Renal and Urology News | Organ Donation & Transplant Matters Resources | Scoop.it

Reported initially via the medical journal The Lancet is this analysis of United Kingdom data of the outcomes of kidney transplantation from deceased donors. Although older Circulatory-Death Donor Kidneys are acceptable for transplantation the results reflect organ donor selection practices, including during the organ retrieval surgery. Plus as noted in the accompanying editorial there has been a relatively high rate of discardment of deceased donor kidneys within the United Kingdom in recent years.

 

The government-funded study of 6,490 kidney transplants also confirmed that donor age over 60 years compared to age under 40 years is associated with an increased risk of graft loss and inferior longer term graft survival, with there also being an added impact of longer cold storage times.

 

To read the online commentary in Renal & Urology News clisk on the banner headline. Access to the online article is via- http://www.thelancet.com

published the first week of March 2013 

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Tobacco Smoking and Solid Organ Transplantation : Transplantation

Tobacco Smoking and Solid Organ Transplantation : Transplantation | Organ Donation & Transplant Matters Resources | Scoop.it

This review of the impact of smoking, both by organ donors and by recipients on transplant outcomes is available free online via the journal Transplantation.

 

Smoking,whether it be in the donor population or in the recipient population impacts on outcomes after organ transplantation. Some of these outcomes are specific to the type of organ being transplanted. This is further explored in the article.

 

For eg. In the deceased donor population smoking becomes one of the risk factors that is taken into consideration when an assessment is made of the overall medical suitability for the organs to be used for transplantation.

 

Image via www.nature.com

 

Deborah Verran's insight:

This article should be of interest to professionals in the organ donation sector as well as in the transplant sector

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Why improving process quality measures may not impact mortality ...

Why improving process quality measures may not impact mortality ... | Organ Donation & Transplant Matters Resources | Scoop.it

What contributes to good results in healthcare? Can measurement of processes assist with the understanding of patient outcomes? The answer is yes and no. Measurement can help but the appropriate metrics have to be used.

 

Recently, a study in the New England Journal of Medicine(NEJM) reported that the Premier demonstration project showed hospitals that performed well on quality process measures did not improve patient mortality rates. Reading this blog posting may help you understand how this result may have been achieved.

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