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Organ Donation & Transplant Matters Resources
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Mechanism helps explain persistence of hepatitis C virus but new treatments on the horizon

Mechanism helps explain persistence of hepatitis C virus but new treatments on the horizon | Organ Donation & Transplant Matters Resources | Scoop.it

The first part of this post is the news that researchers at the University of California, San Diego School of Medicine have identified a mechanism that explains why people with the hepatitis C virus get liver disease. Plus this may be why the virus is able to evade the normal mechanisms in the body that eradicate similar viral pathogens. For more on this story click

on the banner headline.

 

The second part is news on some of the new antiviral combinations which appear promising for the treatment of hepatitis C. For more on this click on either of the following links-

 

http://www.medicalnewstoday.com/releases/275472.php#.U057niNk8H8.twitter

 

http://www.medicalnewstoday.com/releases/275468.php

 

 

 

Deborah Verran's insight:

With hepatitis C being the most common indication for liver transplantation in many countries, any progress in either the understanding of how the virus causes liver disease or in treating this virus is extremely important

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Non-adherence among teen heart transplant recipients widespread, often fatal - ScienceBlog.com (blog)

Non-adherence among teen heart transplant recipients widespread, often fatal - ScienceBlog.com (blog) | Organ Donation & Transplant Matters Resources | Scoop.it

This study looks at medication non-adherence among teen heart transplant recipients and finds that it can be widespread, and is often often fatal as reported via ScienceBlog.com (blog)

 

The study, published online June 4 by the Journal of Heart and Lung Transplantation, looked at eight years' worth of data from the Organ Procurement & Transplant Network in the United States...

Deborah Verran's insight:

Non-adherance with taking the vital immunosuppressive medications post organ transplantation can cost young recipients vital years of life and in the worst cases is rapidly fatal

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Wiley: Incarceration, Marijuana Use and Suicide Attempts May Hinder Liver Transplant Eligibility

Wiley: Incarceration, Marijuana Use and Suicide Attempts May Hinder Liver Transplant Eligibility | Organ Donation & Transplant Matters Resources | Scoop.it

As reported in the journal Liver Transplantation: Social Factors May Hinder Liver Transplant Eligibility http://t.co/Io4ZzCTfkZ

 

Liver transplantation is not just a major surgical procedure but is combined with the requirement for life long adherance to a medication regimen (immunosuppressive medications). This means that potential transplant candidates are carefully evaluated for their ability to be able to comply with what is required both prior to and following the transplant procedure. 

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Sofosbuvir taken before or after liver transplant reduces hepatitis C recurrence - aidsmap

Sofosbuvir taken before or after liver transplant reduces hepatitis C recurrence - aidsmap | Organ Donation & Transplant Matters Resources | Scoop.it

The new anti-viral agent Sofosbuvir taken either before or after liver transplant reduces hepatitis C recurrence as reported via aidsmap.

 

An interferon-free combination of sofosbuvir plus ribavirin administered before liver transplantation prevented hepatitis C recurrence in nearly

two-thirds of cases as recently reported at the AASLD meeting.

 

Sofosbuvir is just one of a number of new anti-viral oral agents that are being trialled for the treatment of hepatitis C (as pictured in the graphic). Hence this is an encouraging report.

 

The combination of Sofosbuvir with a different anti-viral agent Ledipasvir is reported via the Guardian (post publication in The Lancet )-

 

http://www.theguardian.com/science/2013/nov/05/hope-hepatitis-cure-drugs-success-sofosbuvir-ledipasvir?CMP=twt_gu

 

 

Deborah Verran's insight:

Hepatitis C will become a treatable condition. Ongoing tirals mean that more reports will follow on this topic and treatment options will become clearer.

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Augmentin implicated in drug-induced liver injury - Family Practice News Digital Network

Augmentin implicated in drug-induced liver injury - Family Practice News Digital Network | Organ Donation & Transplant Matters Resources | Scoop.it

From Iceland comes this report of a population based study of drug induced liver injury leading to hospitalisation in adults and reported online via the 
Family Practice News Digital Network.

 
The crude incidence of drug-induced liver injury in this series is roughly 19.1 cases per 100,000 inhabitants, with amoxicillin-clavulanate the most commonly implicated agent.

Deborah Verran's insight:

Extreme cases of drug induced liver injury can lead to acute liver failure and hence the requirement for liver transplantation

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