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Organ Donation & Transplant Matters Resources
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ISHLT Announces Latest Results of both the NOVEL and the INSPIRE Lung Trials of EVLP

ISHLT Announces Latest Results of both the NOVEL and the INSPIRE Lung Trials of EVLP | Organ Donation & Transplant Matters Resources | Scoop.it

Two clinical research updates have been announced at the 2014 ISHLT meeting. Both involve the use of ex-vivo lung preservation technology. The Results of the NOVEL Lung Trial Show Great Promise at this stage and more info can be obtained by clicking on the banner headline.

 

The results of the INSPIRE Lung Trial can be accessed by clicking on the following link-

http://www.prweb.com/releases/2014/04/prweb11720765.htm

 

Deborah Verran's insight:

Early stages of understanding the place of ex-vivo lung preservation as an option for both managing and evaluating deceased donor lungs prior to transplantation

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For Lung Transplant, Researchers Surprised to Learn Bigger Appears to Be Better - Science Daily (press release)

For Lung Transplant, Researchers Surprised to Learn Bigger Appears to Be Better - Science Daily (press release) | Organ Donation & Transplant Matters Resources | Scoop.it

For Lung Transplants, Researchers were Surprised to Learn that Bigger Appears to Be Better as reported via
Science Daily (press release)


To date the survival rates for lung transplants, unfortunately, are not as good as with other solid organ transplants like liver, kidney and heart. Hence researchers in the United States looked at data on the size of the donor lungs versus the size of the lung ransplant recipient to see what impact there was with size mismatching.

 

It appears that donor lungs that are slightly larger than the recipients normal lungs may confer a survival advantage over the recipient receiving lungs that are smaller than their own lungs.

Deborah Verran's insight:

An interesting result which may have implications for the allocation of donor lungs to prospective lung transplant recipients.

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FDA Panel Favors Device to Boost Lung Transplant Success - MedPage Today

FDA Panel Favors Device to Boost Lung Transplant Success - MedPage Today | Organ Donation & Transplant Matters Resources | Scoop.it

The news has come that an FDA Panel has given the approval for a normothermic lung preservation device to continue to be used in clinical research in order to boost lung transplant success as reported via MedPage Today.

 

A Canadian center involved in the HELP trial increased the proportion of donated lungs actually transplanted from 25% to 36% after starting to use the EXVIVO lung perfusion device. Of note there remains limited data for the medium to long term outcomes of lungs that have been transplanted after being preserved using this particular device. 

Deborah Verran's insight:

News that the EXVIVO lung preservation device has  received a preliminary limited approval by the FDA in the United States (humanitarian use device exemption)

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