Organ Donation & Transplant Matters Resources
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Organ Donation & Transplant Matters Resources
Combining reports, research findings and topic reviews
Curated by Deborah Verran
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Multi-drug resistant infection spreading globally among cystic fibrosis patients

Multi-drug resistant infection spreading globally among cystic fibrosis patients | Organ Donation & Transplant Matters Resources | Scoop.it
There are concerns that the pathogen mycobacterium abscessus which is notoriously difficult to treat, will prevent some patients undergoing lung transplantation. As reported this last week this pathogen tends to occur in patients with lung disease due to cystic fibrosis.

The study, led by the University of Cambridge and the Wellcome Trust Sanger Institute in the United Kingdom, also suggests that conventional cleaning will not be sufficient to eliminate this particular pathogen, which can be transmitted through contaminated surfaces or in the air.
Deborah Verran's insight:
Important information for healthcare professionals involved in caring for patients being considered for lung transplantation
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New organ preservation technique could replace cold static storage for donated organs

New organ preservation technique could replace cold static storage for donated organs | Organ Donation & Transplant Matters Resources | Scoop.it

For decades, surgeons around the United States have preserved organs in a cold solution as the organs are shipped in coolers to transplant recipients hundreds of miles away.

 

However the development of machine preservation technology is now allowing trials to be undertaken in order to explore whether there are benefits to preserving donated organs differently.

 

However as this article explores although there may be some benefits to machine preservation of donor organs this comes at a cost and it remains to be seen whether the method will be suitable for all donated organs.

Deborah Verran's insight:

Further data is awaited from the ongoing trials of machine preservation of donated hearts, livers and lungs

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An unexpected microbe is lethal for some organ transplant recipents - Science /AAAS

An unexpected microbe is lethal for some organ transplant recipents - Science /AAAS | Organ Donation & Transplant Matters Resources | Scoop.it

A just released research study points the finger at a certain type of bacteria that can cause a lethal increase in the ammonia levels of lung transplant recipients which can then lead on to death.

 

For the first time as the result of scientific detective work the organisms concerned (Ureaplasma type bacteria), appear to become problematic for lung transplant recipients if they become infected with them.

Deborah Verran's insight:

A significant break through in determining a cause for some of the unexplained deaths in lung transplant recipients

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FDA Panel Favors Device to Boost Lung Transplant Success - MedPage Today

FDA Panel Favors Device to Boost Lung Transplant Success - MedPage Today | Organ Donation & Transplant Matters Resources | Scoop.it

The news has come that an FDA Panel has given the approval for a normothermic lung preservation device to continue to be used in clinical research in order to boost lung transplant success as reported via MedPage Today.

 

A Canadian center involved in the HELP trial increased the proportion of donated lungs actually transplanted from 25% to 36% after starting to use the EXVIVO lung perfusion device. Of note there remains limited data for the medium to long term outcomes of lungs that have been transplanted after being preserved using this particular device. 

Deborah Verran's insight:

News that the EXVIVO lung preservation device has  received a preliminary limited approval by the FDA in the United States (humanitarian use device exemption)

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New Bio-Sensors May Save Lung Transplant Patients from Organ Failure

New Bio-Sensors May Save Lung Transplant Patients from Organ Failure | Organ Donation & Transplant Matters Resources | Scoop.it

In the future a new system of sub classifying donor lungs, based on molecular profiling, could make more donor lungs available for transplantation purposes. 

 

This report is of new research on using a molecular probe in order to detect whether donor lungs may be at risk of poor early function following transplantation .

 

This is the first step in the use of this very modern technology in order to provide this particular type of extra information which can be used to assist with making decisions on whether donor lungs are suitable for transplantation. In addition the information may also be used to subclassify the donor lungs into whether they are considered normal or high risk organs for initial poor graft function following transplantation. More on this story can be viewed by clicking on the banner headline

Deborah Verran's insight:

This new molecular probe type of technology will need to be subjected to further trials so that a clearer picture can be gained of both its accuracy and validity 

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Transplant Network Reaches Milestone of 500,000 Deceased Donor Organ Transplants

Transplant Network Reaches Milestone of 500,000 Deceased Donor Organ Transplants | Organ Donation & Transplant Matters Resources | Scoop.it

As of May 19, 2015, the national transplant allocation system developed by United Network for Organ Sharing has coordinated 500,000 organ transplants from deceased donors in the United States since its beginning in October 1987.

Deborah Verran's insight:

A significant mile stone was reached this last week by the United Network of Organ Sharing in the United States

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ISHLT Announces Latest Results of both the NOVEL and the INSPIRE Lung Trials of EVLP

ISHLT Announces Latest Results of both the NOVEL and the INSPIRE Lung Trials of EVLP | Organ Donation & Transplant Matters Resources | Scoop.it

Two clinical research updates have been announced at the 2014 ISHLT meeting. Both involve the use of ex-vivo lung preservation technology. The Results of the NOVEL Lung Trial Show Great Promise at this stage and more info can be obtained by clicking on the banner headline.

 

The results of the INSPIRE Lung Trial can be accessed by clicking on the following link-

http://www.prweb.com/releases/2014/04/prweb11720765.htm

 

Deborah Verran's insight:

Early stages of understanding the place of ex-vivo lung preservation as an option for both managing and evaluating deceased donor lungs prior to transplantation

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For Lung Transplant, Researchers Surprised to Learn Bigger Appears to Be Better - Science Daily (press release)

For Lung Transplant, Researchers Surprised to Learn Bigger Appears to Be Better - Science Daily (press release) | Organ Donation & Transplant Matters Resources | Scoop.it

For Lung Transplants, Researchers were Surprised to Learn that Bigger Appears to Be Better as reported via
Science Daily (press release)


To date the survival rates for lung transplants, unfortunately, are not as good as with other solid organ transplants like liver, kidney and heart. Hence researchers in the United States looked at data on the size of the donor lungs versus the size of the lung ransplant recipient to see what impact there was with size mismatching.

 

It appears that donor lungs that are slightly larger than the recipients normal lungs may confer a survival advantage over the recipient receiving lungs that are smaller than their own lungs.

Deborah Verran's insight:

An interesting result which may have implications for the allocation of donor lungs to prospective lung transplant recipients.

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