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Organ Donation & Transplant Matters Resources
Combining reports, research findings and topic reviews
Curated by Deborah Verran
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Non-adherence among teen heart transplant recipients widespread, often fatal - ScienceBlog.com (blog)

Non-adherence among teen heart transplant recipients widespread, often fatal - ScienceBlog.com (blog) | Organ Donation & Transplant Matters Resources | Scoop.it

This study looks at medication non-adherence among teen heart transplant recipients and finds that it can be widespread, and is often often fatal as reported via ScienceBlog.com (blog)

 

The study, published online June 4 by the Journal of Heart and Lung Transplantation, looked at eight years' worth of data from the Organ Procurement & Transplant Network in the United States...

Deborah Verran's insight:

Non-adherance with taking the vital immunosuppressive medications post organ transplantation can cost young recipients vital years of life and in the worst cases is rapidly fatal

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Study suggests breakthrough in organ transplants

Study suggests breakthrough in organ transplants | Organ Donation & Transplant Matters Resources | Scoop.it

This recent news report of a pilot study in renal transplantation summarises how by infusing selected donor bone marrow cells as well as performing a kidney transplant, 5 out of 8 patients were able to be weaned off immunosuppression for a prolonged period of time.

 

Of note the kidney transplants were all from live donors, and the recipient's had to undergo extra treatment's in order to receive the infusion of the especially prepared cells.

 

Patients who are lucky enough to get a transplant for a failed organ usually face a lifetime on anti-rejection drugs [immunosuppression], which are expensive, have undesirable side effects and are not always effective. Hence although it seems promising, the results from this report will need to be replicated in larger prospective clinical trials in order for this type of regimen to be more widely adopted into practice.

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Positive outcomes in largest liver transplant trial to date - Pharmacy Europe

Positive outcomes in largest liver transplant trial to date - Pharmacy Europe | Organ Donation & Transplant Matters Resources | Scoop.it

This report is on the positive outcomes achieved in the largest liver transplant trial of an immunosuppressive agent to date. New two-year results from the Phase III study in liver transplant recipients with the drug Everolimus in combination with other immunosuppressive agents have confirmed that there was comparable efficacy in the treatment arm to the control arm. Plus superior renal function was seen in the treatment arm during the study period.

 

As a result Everolimus will now become another immunosuppressive agent that may be used in the ongoing management of liver transplant recipients.

 

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