Organ Donation & Transplant Matters Resources
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Organ Donation & Transplant Matters Resources
Combining reports, research findings and topic reviews
Curated by Deborah Verran
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Air-Powered Robotic Sleeve Wraps Around Your Heart To Keep It Pumping

Air-Powered Robotic Sleeve Wraps Around Your Heart To Keep It Pumping | Organ Donation & Transplant Matters Resources | Scoop.it
Researchers from Harvard University and Boston Children's Hospital have developed an innovative robotic sleeve that fits around the heart. As outlined in this online report  the device (pictured) has been successfully trialed in large animals and hence satisfies proof of concept criteria. However in order for the device to meet stringent regulatory standards prior to then being marketed it must now undergo prospective trials in humans.

One advantage of this particular device is that it wraps around the heart and hence is not in contact with circulating blood which can lead to other problems such as excessive clotting.

The relevant research article which has now been published in Science Translational Medicine can be accessed via the following link-

Deborah Verran's insight:
This is an interesting new type of cardiac assist device which now needs to be trialed in humans
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Researchers achieving improved outcomes with Pig-to-Primate Organ Transplants - MIT Technology Review

Researchers achieving improved outcomes with Pig-to-Primate Organ Transplants - MIT Technology Review | Organ Donation & Transplant Matters Resources | Scoop.it

A biotech company’s genetically engineered pigs are now setting new records for outcomes as the result of xenotransplantation of some of the organs into primates.

 

It appears that years of laboratory research are now beginning to deliver promising results with the use of these particular animal organs for transplantation purposes. It may be possible that if the results continue to improve that trials in humans may be contemplated in the not too distant future.

Deborah Verran's insight:

Good summary of the current status of xenotransplantation. The full article can be accessed by clicking on the banner headline.

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UCLA Patient Is First in the World to Successfully Receive a new prototype of a total artificial Heart

UCLA Patient Is First in the World to Successfully Receive a new prototype of a total artificial Heart | Organ Donation & Transplant Matters Resources | Scoop.it

It has been announced this last week that a 44-year-old woman has received a successful heart transplant at Ronald Reagan UCLA Medical Center in the United States, thanks to an experimental Total Artificial Heart designed for smaller patients.

 

This particular smaller model of the Syncardia prototype of the total artificial heart is the first one to have been successfully implanted into a smaller patient.

Deborah Verran's insight:

Another important step in the provision of total artificial heart transplants to patients who are in need

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The BiVACOR artificial heart: developed in Queensland Australia

The BiVACOR artificial heart: developed in Queensland Australia | Organ Donation & Transplant Matters Resources | Scoop.it

This story is about a new type of artificial heart which has been developed in Australia and is now being trialed in a large animal model. This type of heart is unusual in that the flow of blood is not intermittent, hence there is no pulse which can be detected in the recipient.

 

The full article contains information about the developers, the collaborative partnerships that have been required to ensure the research could get to this stage as well as more information about the device itself. This can be accessed by clicking on the banner headline.

 

The hope is that this type of device will ultimately be trialed in humans. If it is successful then it could be an alternative to conventional heart transplantation in selected cases.

Deborah Verran's insight:

Well put together article, containing fine graphics. A must read for anyone interested in medical technology

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Proceed II International Heart Transplant Trial Results Revealed at ISHLT 34th ... - PR Web (press release)

Proceed II International Heart Transplant Trial Results Revealed at ISHLT 34th ... - PR Web (press release) | Organ Donation & Transplant Matters Resources | Scoop.it

The Proceed II International Heart Transplant Trial Results are being Revealed at the ISHLT 34th meeting.

 

Preliminary outcome data are favorable for heart transplant outcomes where donor hearts were maintained on the TransMedics Organ Care System device compared to being placed into conventional cold storage prior to transplantation.

 

Further comments from medical professionals on this new technology can be viewed via this link-

http://www.inquisitr.com/1207466/transporting-a-heart-in-a-box-is-a-great-advance-says-dr-mark-plunkett/

 

Deborah Verran's insight:

Promising preliminary results with the use of ex-vivo normothermic heart preservation

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TransMedics keeps donor hearts beating en route to transplant patients - Al Jazeera America (blog)

TransMedics keeps donor hearts beating en route to transplant patients - Al Jazeera America (blog) | Organ Donation & Transplant Matters Resources | Scoop.it

The new TransMedics OCS device keeps donor hearts beating en route to transplant patients

"A human organ has never been kept alive outside of a human body until this machine became a clinical reality,"

 

For a description of this new technology, along with images as well as video footage from the University of California Los Angeles heart transplant programme, click on the banner headline.

Deborah Verran's insight:

This new technology may also allow for the transport of donated hearts across wider geographic regions than is possible currently.

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Tissue engineering: How to build a heart - Nature.com

Tissue engineering: How to build a heart - Nature.com | Organ Donation & Transplant Matters Resources | Scoop.it

An update on the status of Tissue engineering titled: How to build a heart is published online via Nature.com

 

The heart is the third most needed organ after the kidney and the liver, with a waiting list of about 3,500 in the United States alone, but it poses extra specific challenges for transplantation. The research into bio-engineering a heart in the laboratory is still at a very early stage as outlined in the article...

Deborah Verran's insight:

A very good update as to where organ and tissue engineering has currently got to

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ViosWorks MRI Software Visualizes Blood Flow In and Around Heart (VIDEO)

ViosWorks MRI Software Visualizes Blood Flow In and Around Heart (VIDEO) | Organ Donation & Transplant Matters Resources | Scoop.it

At RSNA in Chicago this last week GE Healthcare introduced its ViosWorks software for analyzing cardiac MRI scans.

 

The software allows for the real time imaging of blood flow which is evident in the video which is contained within this online article. This can be accessed via clicking on the banner headline.

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New organ preservation technique could replace cold static storage for donated organs

New organ preservation technique could replace cold static storage for donated organs | Organ Donation & Transplant Matters Resources | Scoop.it

For decades, surgeons around the United States have preserved organs in a cold solution as the organs are shipped in coolers to transplant recipients hundreds of miles away.

 

However the development of machine preservation technology is now allowing trials to be undertaken in order to explore whether there are benefits to preserving donated organs differently.

 

However as this article explores although there may be some benefits to machine preservation of donor organs this comes at a cost and it remains to be seen whether the method will be suitable for all donated organs.

Deborah Verran's insight:

Further data is awaited from the ongoing trials of machine preservation of donated hearts, livers and lungs

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Europe's first heart transplant from a donation after circulatory death organ donor

Europe's first heart transplant from a donation after circulatory death organ donor | Organ Donation & Transplant Matters Resources | Scoop.it

Surgeons at the Papworth hospital in Cambridgeshire, the United Kingdom have performed the first successful heart transplant in Europe using a heart retrieved from a donation after circulatory death (DCD) organ donor.

 

 Importantly the heart was placed on the TransMedics organ Care System device (pictured), following its removal from the deceased donor. This allowed for an assessment to be made as to the suitability of the heart to then be transplanted. A video which includes footage of the man who received the donor heart can be accessed by clicking on the banner headline.

 

This follows on from the report from Australia of two successful heart transplants from DCD organ donors in 2014 http://sco.lt/7Z57IX

 

Deborah Verran's insight:

News that a second heart transplant programme has successfully transplanted the heart from a DCD organ donor

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'Heart in a box': Pioneering device keeps donor organs alive OUTSIDE the body

'Heart in a box': Pioneering device keeps donor organs alive OUTSIDE the body | Organ Donation & Transplant Matters Resources | Scoop.it


Traditionally, all donor organs are placed in a cool-box and surrounded by ice to prevent them deteriorating on their journey between hospitals.

 

However new technology in the form of transportable machines is

leading to changes in how some organs are maintained following their removal from the donor.

 

This report focuses on the preliminary experience with the use of normothermic machine preservation in the Harefield heart transplant programme in the United Kingdom

Deborah Verran's insight:

Another report on the preliminary use of machine preservation in heart transplantation. Further data from the prospective clinical trials that are currently being undertaken is now awaited

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Pour la première fois, un coeur artificiel a été greffé à un homme - Le Nouvel Observateur

Pour la première fois, un coeur artificiel a été greffé à un homme - Le Nouvel Observateur | Organ Donation & Transplant Matters Resources | Scoop.it
Le Nouvel Observateur
Pour la première fois, un coeur artificiel a été greffé à un homme
Le Nouvel Observateur
Le patient n'était pas éligible à une greffe en raison de son âge avancé.

 

For another report in Engish click on this link-

http://www.eteknix.com/artificial-heart-offers-hope-transplant-list/

 


Via nathalie Bissot-Campos
Deborah Verran's insight:

For the first time an artificial heart has been transplanted into an adult male in France. Although the article is in French it can be translated into English via Google translate. The short accompanying video provides a glimpse of the actual device

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Beating new life into a heart transplant - Medical Xpress

Beating new life into a heart transplant - Medical Xpress | Organ Donation & Transplant Matters Resources | Scoop.it

Reported online via Medical Xpress is this article: Beating new life into a heart transplant, which reports on research efforts within the United Kingdom.

 

The aim of this type of research is to explore how donor hearts which would not be medically suitable for transplantation, can then be 're-conditioned'.  This could lead to an increase in the number of donor hearts which are then utilised for transplantation.

 

As Professor James Neuberger, Associate Medical Director at NHS Blood and Transplant said: "Surgeons are very keen to transplant every donated organ that can be transplanted safely...

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