Organ Donation & Transplant Matters Resources
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Organ Donation & Transplant Matters Resources
Combining reports, research findings and topic reviews
Curated by Deborah Verran
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Tissue engineering: Organs from the lab - Nature.com

Tissue engineering: Organs from the lab - Nature.com | Organ Donation & Transplant Matters Resources | Scoop.it

The body's organs are more complex than any factory. Attempts to mirror their physiology in the laboratory are now getting closer to capturing their individual intricacies.

 

This well written article outlines the gains that have been made with organ and tissue engineering, particularly the "organ on a chip" technology which is now increasingly being used for research and testing purposes.

 

However due to the inherent complexities in all of the human organs there is still a lot more in the way of research which needs to be undertaken. This is in order to allow step wise progress in the bioengineering of organs to be made.

Deborah Verran's insight:

The latest summary of this fascinating area of ongoing research.

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U.S. trial tests machine that 'reconditions' lungs outside of the body

U.S. trial tests machine that 'reconditions' lungs outside of the body | Organ Donation & Transplant Matters Resources | Scoop.it
ST. LOUIS (Reuters) - A machine that 'reconditions' a donor's lungs outside the body before they are transplanted into a recipient is undergoing tests in the United States in the hope that it can radically improve survival rates for people with lung disease.

The XVIVO machine preservation device will be used to recondition marginal deceased donor lungs in 16 centers lead to an increase in the number of donor lungs that can be successfully transplanted.

In another recent article posted online a short video also contains information on the XPS XVIVO device-


Deborah Verran's insight:
The results of this important prospective clinical trial are now awaited with interest.
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Dead could be brought 'back to life' in groundbreaking project - via the use of stem cells

Dead could be brought 'back to life' in groundbreaking project - via the use of stem cells | Organ Donation & Transplant Matters Resources | Scoop.it
Stem cells have been used to try and treat a number of neurological disorders including Parkinsons disease as well as damage to the spinal cord leading to paralysis.

However in what may be currently considered a giant leap of faith a United States biotech company (Bioquark), has gone through the initial stages of seeking regulatory approval for a trial utilizing stem cells to treat patients following the declaration of brain death. The aim is to restore neurological function via a combination of supportive medical treatments along with the injection of stem cells into the spinal cord.

The initial proof of concept study titled the 'Reanima project' will be carried out in India. The study protocol can be viewed via the following link-

https://clinicaltrials.gov/ct2/show/NCT02742857?term=stem+cells+AND+brain+injury&rank=11 ;

More on the story can be viewed by clicking on the following link- 


In addition an ethicist asks the question as to whether this planned trial can truly deliver acceptable results-



Deborah Verran's insight:
It seems highly unlikely that any patient in whom a sound diagnosis of brain death has been made, will have their brain function restored to any significant degree via this approach in the near future.
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Improved Detection for Deadly Prion Diseases

Improved Detection for Deadly Prion Diseases | Organ Donation & Transplant Matters Resources | Scoop.it
A new assay now offers the potential for there to be an improved sensitivity in practice compared to current tests for transmissible spongiform encephalopathies, researchers report.

Up to now the diagnosis of these types of conditions has required that tissue taken via biopsies be processed in the laboratory. This newly developed assay may be the first of a new generation of laboratory based tests that can be performed on blood, saliva or urine for these types of disorders. Further data from the prospective use of this particular test in clinical practice is now awaited.
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A patient has 'caught' a kiwi fruit allergy from a bone marrow transplant

A patient has 'caught' a kiwi fruit allergy from a bone marrow transplant | Organ Donation & Transplant Matters Resources | Scoop.it
This is the first proof that this particular type of transplant procedure can lead to the spread of specific food allergies from the donor to the recipient. The fact that the allergy developed in the recipient reflects transmission of the cells responsible for the immune response that underpins the particular allergy in question.

Similar cases have been reported on occasion in liver transplant recipients.
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USFDA issues guidelines to cut Zika transmission via human tissue and organs

USFDA issues guidelines to cut Zika transmission via human tissue and organs | Organ Donation & Transplant Matters Resources | Scoop.it
The US Food and Drug Administration has said that the Zika virus can be transmitted via donation of umbilical cord blood, placenta and growth tissues.

For more information the full story can be accessed by clicking on the banner headline
Deborah Verran's insight:
The US FDA has now issued important guidelines for reducing the risk of transmission of zika virus via either human tissues or human organs.
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Scientists Just 3D Printed a Transplantable Human Ear

Scientists Just 3D Printed a Transplantable Human Ear | Organ Donation & Transplant Matters Resources | Scoop.it

Scientists have developed an innovative 3D bioprinter capable of generating replacement tissue that’s strong enough to withstand transplantation.

 

However there remain limitations as to what type of tissue can be bioprinted and why this continues to be the case.

 

However in this detailed online report an outline is provided as to how a bioprinter was used to help generate the various tissues that were then implanted into animals to see if they remained viable.

 

A video of the ITOP system in action can be viewed via the following link-

https://youtu.be/wFFkBW7acOI

 

Deborah Verran's insight:

Another small step has been achieved as part of the ongoing efforts to try and reliably bio-print human tissues. At this stage the possibility of being able to bio-print human organs for transplantation purposes remains a distant goal.

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Sri Lanka Suspends Kidney Transplants for Foreigners After India Arrests

Sri Lanka Suspends Kidney Transplants for Foreigners After India Arrests | Organ Donation & Transplant Matters Resources | Scoop.it

The Sri Lankan government last week suspended all kidney transplants for foreigners, after Indian police said they were investigating alleged organ sales.

 

This has come about following reports of organ trading involving individuals who then traveled from India to Sri Lanka in order to undergo the transplant surgery.

Deborah Verran's insight:

Results of the investigation are now awaited. Of note this pertains to live donor kidney transplantation.

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Leonard Bailey MD First paed heart transplant in the USA

HealthFeed provides the most trusted health video content on YouTube with a network of professional experts.

Doctors and experts provide research and expertise in a short succinct format.

 

Here Dr Leonard Bailey talks about the first paediatric heart transplant in the United States and how the lessons learnt helped pave the way for the successful cases which followed.

 

 

Deborah Verran's insight:

An interesting perspective on how paediatric heart transplantation became a clinical reality in the United States.

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DCD heart transplant in China: Heart stops beating, revives 7 hours later

This is an online report of a successful heart transplant surgical procedure in east China. A heart transplant in Fujian Province was successful even though the donor organ had stopped beating for a period of time in the donor prior to its retrieval.

 

Although there is limited information in this video, it does seem that the donor heart was retrieved from a DCD donor and then transported to the recipient hospital where it was then transplanted.

Deborah Verran's insight:

This is an indication that heart transplantation from DCD donors is now proceeding in China

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Lanie Ross - When Altruism Goes Awry: Live Kidney Donors in End Stage Renal Disease

This lecture titled 'When Altruism Goes Awry: Living Kidney Donors in End Stage Renal Disease' was delivered via Lanie Ross, MD, University of Chicago November 13, 2015 

 

It explores what is known about live kidney donors who have gone on to develop end stage renal failure within the United States. It also outlines the current limitations of registry data and how this may be improved.

Deborah Verran's insight:

This talk will be of interest to healthcare professionals with a role in the oversight and management of living kidney donation.

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The 7 forms of courage every leader should demonstrate

The 7 forms of courage every leader should demonstrate | Organ Donation & Transplant Matters Resources | Scoop.it

Through years of consulting to many organizations, I’ve been blessed to work with wonderful, accomplished leaders......

 

This insight has led to the this author crafting this online article which breaks down the types of courage which are required from leaders if they are to remain effective in leading either teams or organizations


Via Anne Leong
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Sandeep Gautam's curator insight, November 26, 2015 1:35 AM

do you have the courage to be a leader?

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Inequality in US organ transplants: Researchers detail how the wealthy leverage the opportunity of being allowed on to multiple lists

Inequality in US organ transplants: Researchers detail how the wealthy leverage the opportunity of being allowed on to multiple lists | Organ Donation & Transplant Matters Resources | Scoop.it

It appears that in the United States patients who are financially well off are able to leverage a loop hole in the organ donation system. That is they are able to be on multiple waiting lists for an organ transplant.

 

As revealed by research that was recently presented at a medical scientific meeting, patients who were on wait lists at multiple centers had higher transplant rates. The reasons for this are explored further in the online article which can be viewed by clicking on the banner headline.

Deborah Verran's insight:

A unique loophole in the United States organ donation system provides patients who are well with the opportunity to be listed on more than one transplant centre's waiting list.

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BPoD | Colourful Cornea

BPoD | Colourful Cornea | Organ Donation & Transplant Matters Resources | Scoop.it
Colourful Cornea - Biomedical pictures for May 2016.

This close up image is of a mouse cornea with the cell nuclei colored blue. Scientists are studying lymphangiogenesis which can contribute to abnormalities of the cornea, including after corneal transplantation. 
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Human-embryo editing now covered by stem-cell guidelines

Human-embryo editing now covered by stem-cell guidelines | Organ Donation & Transplant Matters Resources | Scoop.it

New international guidelines have just been published by the International Society of Stem Cell Research (ISSCR), which cover all aspects of stem-cell research. This is an attempt to fend off the need for further government regulation that could impede this particular  research including the manipulation of human embryos in the laboratory setting.


To read more on this story click on the following link-


http://www.nature.com/news/human-embryo-editing-now-covered-by-stem-cell-guidelines-1.19909


In addition calls are being made for there to be more realistic and responsible reporting of stem cell research which has suffered in recent years from 'too much hype'-



http://www.bloomberg.com/news/articles/2016-05-12/stop-hyping-stem-cell-science-say-stem-cell-scientists


Deborah Verran's insight:
This will be of interest to anyone following the current research into stem cells and tissue engineering
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Scientists Learn to Detect Zika Virus Using Nuclear-Derived Technique

Scientists Learn to Detect Zika Virus Using Nuclear-Derived Technique | Organ Donation & Transplant Matters Resources | Scoop.it
More than thirty doctors, epidemiologists, microbiologists and laboratory technicians from Latin America, the Caribbean and Africa learned how to use a nuclear-derived technique to detect the Zika virus during IAEA training courses this month.

These courses are being run in order to assist with the scaling up of reliable laboratory testing which is now required in a number of countries in order to detect this particular virus in affected patients.
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In a first, liver and kidney from an HIV-infected donor are transplanted into HIV-positive patients in the USA

In a first, liver and kidney from an HIV-infected donor are transplanted into HIV-positive patients in the USA | Organ Donation & Transplant Matters Resources | Scoop.it
In a first that gives HIV-infected patients yet another chance for long lives, surgeons at Johns Hopkins University Medical Center have transplanted a kidney and a liver from a deceased donor who was HIV-positive into two HIV-positive recipients.

This represents the culmination of efforts by both professional organizations and community groups to lift the previous ban that was in place which prohibited the transplantation of organs from HIV positive organ donors.

For more on the story including additional information, click on the banner headline to this story.
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Surgeons to study use of hepatitis C positive kidneys for transplantation

Surgeons to study use of hepatitis C positive kidneys for transplantation | Organ Donation & Transplant Matters Resources | Scoop.it
Transplant surgeons are about to do something long considered taboo: put kidneys from donors with hepatitis C into recipients without the infection in two centers within the United States.

Now that there are new antiviral drugs are available to treat hepatitis C this has led to a push to increase the rates of organ transplantation from donors who are hepatitis C positive. 

Up to now it was only possible to transplant the organs from hepatitis C positive organ donors into recipients who were also hepatitis C positive. However in these two proposed pilot studies carefully selected and consented potential kidney transplant recipients will be able to receive the kidneys from donors with hepatitis C if they also agree to be closely monitored post transplant and in addition receive a course of direct acting antiviral medication for the hepatitis C.
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TransMedics Announces The World's First Human Liver Transplantation Using The Organ Care System (OCS™) Liver Technology & The Initiation of The OCS™ Liver PROTECT U.S. Pivotal Trial: TransMedics, Inc.

TransMedics Announces The World's First Human Liver Transplantation Using The Organ Care System (OCS™) Liver Technology & The Initiation of The OCS™ Liver PROTECT U.S. Pivotal Trial: TransMedics, Inc. | Organ Donation & Transplant Matters Resources | Scoop.it

TransMedicsInc announces the transplantation of the first human liver using the #OCSLiver ex-vivo preservation device as well as initiation of the multicentre prospective PROTECT trial.

 

For more information click on the banner headline

Deborah Verran's insight:

This is one of at least three ex-vivo liver preservation devices now in trial around the world. The outcome data are awaited with interest noting that the benefits of ex-vivo liver preservation will need to be clear for this type of technology to be incorporated into routine practice.

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Johns Hopkins to Perform First H.I.V.-Positive Organ Transplants in U.S.

Johns Hopkins to Perform First H.I.V.-Positive Organ Transplants in U.S. | Organ Donation & Transplant Matters Resources | Scoop.it

Following passage of legislation to allow HIV positive individuals to become organ donors in the United States, the next step has involved guidelines being developed to allow this to become a clinical reality.


Now the John Hopkins hospital has said that it would become the first in the nation to perform kidney and liver transplants between H.I.V.-positive donors and H.I.V.-positive patients. This is under a strict research protocol and will require that selection criteria are applied both to the organ donors as well as the transplant recipients. 

Deborah Verran's insight:

The outcomes of these particular organ transplants will now be awaited with interest noting that the many complexities that are involved.

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Organ Transplants Up Slightly in the United States, Hospitals Urged to Do More

Organ Transplants Up Slightly in the United States, Hospitals Urged to Do More | Organ Donation & Transplant Matters Resources | Scoop.it

Recently it was reported that there had been an increase in the number of organ transplants performed within the United States for 2015 compared to 2014.

 

However this does not mean that efforts to improve on this outcome now cease. In this article published online, several of the leaders in the Organ Procurement Network outline their thoughts on what needs to happen in order to improve on this outcome. One.transplant surgeon is quoted as stating that  "registering donors is "part of our responsibility as caregivers".

Deborah Verran's insight:

A thought provoking article which will be of interest to healthcare professionals with leadership and/or management roles in both organ donation and transplantation.

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Draft guidelines issued to tackle illegal kidney trade - The Times of India

Draft guidelines issued to tackle illegal kidney trade - The Times of India | Organ Donation & Transplant Matters Resources | Scoop.it

In a move to bring in greater transparency and tackle the illegal kidney trade while prioritising those in urgent need of renal transplant across India, the National Organ and Transplant Centre has come out with draft guidelines that aim to determine the criteria for receiving a kidney from a deceased donor.

 

This is the first stage in a process that has commenced within India of moving to a national centrally co-ordinated system for the allocation of all organs from deceased donors.

Deborah Verran's insight:

This will be of interest to healthcare professional with an interest in policy guidelines pertaining to organ donation as well as organ transplantation,

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Kidney donor’s death a ‘nightmare scenario’ for UCSF program

Kidney donor’s death a ‘nightmare scenario’ for UCSF program | Organ Donation & Transplant Matters Resources | Scoop.it

News from the United States that the University of California San Francisco (UCSF) has suspended its live donor kidney transplant program whilst an investigation is carried out into the recent death of a live donor following surgery.  

 

UCSF’s suspension of its living donor program for kidney transplants this week after the death of a donor highlights a rare but potential complication for a procedure that’s typically an altruistic gift by a friend or family member to a patient who requires a kidney transplant.

 

For more on this story click on the banner headline....

Deborah Verran's insight:

A reminder that live kidney donation involves major surgery both for the donor as well as the recipient and hence is not risk free.

 

Results of the investigation into the death of this particular donor are now awaited

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ViosWorks MRI Software Visualizes Blood Flow In and Around Heart (VIDEO)

ViosWorks MRI Software Visualizes Blood Flow In and Around Heart (VIDEO) | Organ Donation & Transplant Matters Resources | Scoop.it

At RSNA in Chicago this last week GE Healthcare introduced its ViosWorks software for analyzing cardiac MRI scans.

 

The software allows for the real time imaging of blood flow which is evident in the video which is contained within this online article. This can be accessed via clicking on the banner headline.

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Charges brought against makers of dietary supplement linked to liver damage - PBS NewsHour

Charges brought against makers of dietary supplement linked to liver damage - PBS NewsHour | Organ Donation & Transplant Matters Resources | Scoop.it

A Dallas company that had been ordered to recall a dietary supplement pill because of links to liver damage has now been indicted along with several of its executives on charges that they intentionally mis-branded their products and then continued to sell them.

 

 This is a postscript to the chain of events involving a nutritional supplement marketed under the label OxyElite Pro which was associated with cases of acute liver failure, particularly within the United States. Some of the patients with acute liver failure subsequently required liver transplantation due to the severity of their medical condition.

Deborah Verran's insight:

A cautionary tale of a chain of events surrounding a nutritional supplement that failed to meet regulatory standards within the United States.

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Campaign uses Apple Store opening queue clip to encourage organ donor registration

Campaign uses Apple Store opening queue clip to encourage organ donor registration | Organ Donation & Transplant Matters Resources | Scoop.it

A Belgian campaign group used the queue for the recent opening of the Apple Store in Brussels to create a clever video encouraging people to register as organ donors. People on the waiting list for organ transplantation switched places with people waiting for the latest Apple gadgets in exchange for a commitment to register as an organ donor.

 

The video can be accessed via the landing page which is accessed via clicking on the banner headline.

Deborah Verran's insight:

Clever analogy of waiting in line compared to waiting on an organ transplant waiting list

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