Oomycete pathogens encode RNA silencing suppressors
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Rescooped by Kokkat Johnson George from Plant Pathogenomics
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Genome Biology: From pathogen genomes to host plant processes: the power of plant parasitic oomycetes (2013)

Genome Biology: From pathogen genomes to host plant processes: the power of plant parasitic oomycetes (2013) | Oomycete pathogens encode RNA silencing suppressors | Scoop.it

Recent pathogenomic research on plant parasitic oomycete effector function and plant host responses has resulted in major conceptual advances in plant pathology, which has been possible thanks to the availability of genome sequences.


Via Kamoun Lab @ TSL
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Rescooped by Kokkat Johnson George from Trends in MPMI
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Nature Genetics: Oomycete pathogens encode RNA silencing suppressors (2013)

Nature Genetics: Oomycete pathogens encode RNA silencing suppressors (2013) | Oomycete pathogens encode RNA silencing suppressors | Scoop.it

Effectors are essential virulence proteins produced by a broad range of parasites, including viruses, bacteria, fungi, oomycetes, protozoa, insects and nematodes. Upon entry into host cells, pathogen effectors manipulate specific physiological processes or signaling pathways to subvert host immunity. Most effectors, especially those of eukaryotic pathogens, remain functionally uncharacterized. Here, we show that two effectors from the oomycete plant pathogen Phytophthora sojae suppress RNA silencing in plants by inhibiting the biogenesis of small RNAs. Ectopic expression of thesePhytophthora suppressors of RNA silencing enhances plant susceptibility to both a virus and Phytophthora, showing that some eukaryotic pathogens have evolved virulence proteins that target host RNA silencing processes to promote infection. These findings identify RNA silencing suppression as a common strategy used by pathogens across kingdoms to cause disease and are consistent with RNA silencing having key roles in host defense.


Via Kamoun Lab @ TSL, Suayib Üstün, CP
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