The International Year of Light provides a good opportunity to revisit the early studies on the optical properties of X-rays. X-rays were discovered by W. C. Röntgen on the evening of 8 November 1895 while he was redoing some of Hertz’s experiments on cathode rays. By the end of the year, even before informing the world of his discovery, he had observed the basic properties of X-rays: like light, they propagate as straight lines and are diffused by turbid media, but are not deflected by a prism,
The interplay between host genetics, tumor microenvironment and environmental exposure in cancer susceptibility remains poorly understood. Here we assessed the genetic control of stromal mediation of mammary tumor susceptibility to low dose ionizing radiation (LDIR) using backcrossed F1 into BALB/c (F1Bx) between cancer susceptible (BALB/c) and resistant (SPRET/EiJ) mouse strains. Tumor formation was evaluated after transplantation of non-irradiated Trp53-/- BALB/c mammary gland fragments into cleared fat pads of F1Bx hosts. Genome-wide linkage analysis revealed 2 genetic loci that constitute the baseline susceptibility via host microenvironment. However, once challenged with LDIR, we discovered 13 additional loci that were enriched for genes involved in cytokines, including TGFβ1 signaling. Surprisingly, LDIR-treated F1Bx cohort significantly reduced incidence of mammary tumors from Trp53-/- fragments as well as prolonged tumor latency, compared to sham-treated controls. We demonstrated further that plasma levels of specific cytokines were significantly correlated with tumor latency. Using an ex vivo 3-D assay, we confirmed TGFβ1 as a strong candidate for reduced mammary invasion in SPRET/EiJ, which could explain resistance of this strain to mammary cancer risk following LDIR. Our results open possible new avenues to understand mechanisms of genes operating via the stroma that affect cancer risk from external environmental exposures.
Rapid particle acceleration is possible using a fixed-field alternating-gradient machine[mdash]but /`scaling/' in its design has been necessary to avoid beam blow-up and loss. The demonstration now of acceleration in such a machine without scaling has positive implications for future particle accelerators.
A study conducted in 2013 showed that about 70–80% of teens and young adults in the United States own a smartphone.1 Furthermore the number of tablet PC users in the United States will increase up to more than 80% by 2015. 2 As a result, these devices have increasingly become everyday tools, particularly for the younger generation. In recent years, various articles have been published about the use of smartphones and tablet PCs as experimental tools especially in the physics classroom. This is possible because today's smartphones and tablet PCs are equipped with many sensors, which can be used to perform quantitative measurements of sound, acceleration, magnetic flux density, air pressure, light intensity, humidity, angular velocity, temperature, or position on Earth (GPS). While previous articles mainly present experiments on mechanics or acoustics, in which the acceleration sensor or the microphone is used (for a synopsis of different examples, see Ref. 3 ; for recent papers, see Refs. 4–11 ), in this article we focus on experiments for studying radioactivity using the camera sensor.
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