"Ginger" mice are found to be more susceptible to melanoma even without any exposure to ultraviolet radiation.
Fair-skinned, red-haired people know — sometimes through painful experience — that they are more susceptible to the damaging effects of the Sun’s ultraviolet (UV) rays, including sunburn, skin ageing and a higher risk of skin cancers. But a study suggests that in mice, the pigment responsible for reddish coloring has a role in the development of melanoma.
“There is something about the redhead genetic background that is behaving in a carcinogenic fashion, independent of UV,” says David Fisher, a cancer biologist at Massachusetts General Hospital in Boston, who led the study. “It means that shielding from UV would not be enough.”
Compared to people with darker skin, those with fair, freckly skin and red hair produce a different form of the pigment melanin. This red–yellow form, called pheomelanin, is less effective at protecting the skin from UV damage than the darker form, eumelanin. The difference is caused by a mutation in the gene MC1R.
But for a number of years there have been hints that UV exposure alone might not account entirely for the risk of melanoma in redheads. Fisher and his team wanted to investigate the molecular backdrop for this increased risk. The researchers looked at how melanomas develop in mouse models of olive-skinned, ginger and albino colouring. The last group had the same genetic background as the dark-skinned mice but lacked the enzyme needed to synthesize melanin. The researchers also tweaked each group’s genes to be more susceptible to developing benign moles, which Fisher says is a probable first step in the development of melanoma.
The researchers planned to expose the mice to UV light and monitor differences in melanoma development. But before they got to that part of the experiment, about half the ginger mice had developed melanomas. Fisher says that he and his team were shocked. “The first thing we needed to do was bring a UV meter into the animal room to be sure there wasn’t some inadvertent UV being radiated out of the light bulbs or something,” he says. “And it turned out there was not.” The result suggested that the pigment itself was a cause of melanoma. The researchers suggest that the increased melanoma risk could have something to do with the pigment-production process, or a by-product of it, in melanin-containing cells called melanocytes.
this article shows that red heads are more prone to skin cancer. “There is something about the redhead genetic background that is behaving in a carcinogenic fashion, independent of UV,” says David Fisher.
Even without the sun, redheads are able to get skin cancer from UV lights. This is a terrible result for red heads as they are prone to skin cancer. So they must slip, slop, slap and wrap to minimise their risks of skin cancer.
Dr Ala Alwan said lifestyle diseases are responsible for 63 per cent of global deaths based on WHO's estimates for 2008. Which is an enormous amount. The main causes of the lifestyle disease are tabacoo, poor diet and hurmful amounts of alcohol.
having tabacoo and harmful use of alcohol abd lead to many bad diseases such as diabetes.
Why do people get fat, increasing their personal risk of heart disease, diabetes and other "lifestyle" diseases and society's risk of fiscal collapse from the expense of treating millions of people with those ailments? Conventional wisdom, favored by governments and a vast and growing "wellness industry" around the world, is that it's because individuals can't control themselves.
Why do people get fat, increasing their personal risk of heart disease, diabetes and other "lifestyle" diseases and society's risk of fiscal collapse from the expense of treating millions of people with those ailments?
What the article is stating is tht rather telling people that you should be excersing, people should be educating others on the effects and how to avoid obesity
Eat whole foods. Exercise. Meditate. Rely on supportive family and friends. All of these things have been linked, whether independently or together, with better health. And now, a new study shows it's never too late to start reaping the benefits of a healthy lifestyle.
The study, published in the journal The Lancet Oncology, shows that healthy lifestyle changes can have an impact on aging and age-related diseases on a cellular level, by increasing the length of telomeres.
Eating healthy foods leads to a healthy lifestyle and it is never to late to statrt.
"We know from earlier studies that eating an unhealthy diet, smoking cigarettes, being under chronic emotional stress, loneliness and depression may shorten telomeres. But this is the first one we can actually increase the length of them," said the doctor
This article is great for parents and carers to read if they are trying to control their risk taking kids. I also believe it is wise for the teenager to have a read of the article as it will help them co-operate with their parent or gaurdian.
This srticle shows many wse tactics in controling your kids such as not pressuring them or totally isolating them.
The young women are drinking alot more than what they used to. They are now drinking almost the same amount as men. The alcoholl related incidents that the ambulance as had to make for women have almost doubled since 2002.
This article shows that Australia has one of the highest rates of survivng breast cancer. The statistics show found overall three-year survival was highest in Australia (92%) which is great news for current breat cancer patients.
An eight-year-old Chinese girl has become the mainland's youngest lung cancer patient, with her illness blamed directly on environment factors.
The girl from Jiangsu lived by a busy road where she inhaled all kinds of dust and particles, China News Service cited Dr Feng Dongjie of Jiangsu Cancer Hospital as saying. These included superfine PM2.5 particles, less than 2.5 microns wide, that are considered the most dangerous component of smog, Feng said.
The country's breakneck urbanisation and industrialisation has created some of the world's worst urban pollution, which is blamed for soaring rates of cancer and respiratory diseases.
In Beijing, which has suffered frequent, severe smog in recent years, deaths from lung cancer rose by 56 per cent from 2001 to 2010. A fifth of all cancer patients suffer lung cancer, figures from the Beijing Health Bureau show. It became the leading cause of cancer deaths among men in the capital and the second-biggest among women, after breast cancer, in 2010.
The World Health Organisation's "2010 Global Burden of Disease" study found that air pollution accounted for 1.2 million premature deaths worldwide in 2010, including 140,000 deaths from lung cancer.
Last month the WHO's International Agency for Research on Cancer said that air pollution from traffic and industrial fumes caused lung cancer and was also linked to bladder cancer.
Air pollution, mostly caused by transport, power generation, industrial or agricultural emissions and residential heating and cooking, was found to pose similar health risks to breathing in second-hand tobacco smoke.
The WHO said that in 2010, 223,000 people died from lung cancer worldwide resulting from air pollution.
An eight year old girl becomes china's youngest lung cancer patient .Lung cancer is the most common cancer in Asia, Dr Hao Xishan, a noted oncologist. this is because of the pollution which is produced by thetransport, power generation, industrial or agricultural emissions and residential heating and cooking.
This is a deadly result as this could happen to anyone who lives in a heavy polluted region.
Sugar fuels cancer. A new study has indicated that blocking dietary sugar can reduce tumor development risk and progression of cancer cells.
For the study, Dr. Cagan and his team engineered fruit flies to express Ras and Src, two important oncogenes, resulting in the development of small head tumors. After feeding the flies a high-sugar diet promoting insulin resistance, they found that high dietary sugar acts together with Ras and Src to increase insulin sensitivity specifically in tumor cells. As MedicalNewsToday reports, “By ramping up signaling of an important pathway called Wingless/Wnt, they increased tumor cells’ insulin receptors to further promote insulin sensitivity. This cascade of activity changed these small, weak tumors and caused them to begin growing aggressively”.
Using these newly identified drug targets (glucose, the RAs/Src oncogenes, and Wingless/Wnt signaling), the researchers identified compounds that could block the process. Using three different drug treatments, the team attacked the three different targets. Together, they “substantially reduced tumor size and progression.” ...
Obesity and type 2 diabetes are preventable lifestyle diseases. These are conditions we control. And if they are creating an environment that fosters prolific tumor growth, we can use that knowledge to combat both cancer and the metabolic disorders that increase the risk of cancer.
-Kids are increasingly self-medicating to deal with the pressure. Forty percent of high-school students report using marijuana (up from 31 percent in 1991). In college, 40% percent of kids under age 21 report “binge drinking”—having five or more drinks on one occasion—in the last month.
-Kids also take prescription medications to cope. I can’t find official figures, but consensus among college administrators, who get counts from their health centers, is that at least a quarter of students are taking prescription drugs for depression and anxiety.
-Thirteen to 24 percent of high school students cut or injure themselves deliberately. Self-injury is a distressingly common way for kids to express emotional pain and relieve stress and anxiety.
-A quarter of college-age women binge-and-purge to “control their weight” (binge eating and then vomiting is a sign of the eating disorder bulimia). Anorexia is the third most common chronic illness among adolescents, and eating disorders have the highest mortality rate of any mental illness.
-Kids are increasingly depressed, perfectionistic, and committing suicide. A nationwide survey of college students at two- and four-year institutions found that nearly 30 percent of college students felt “so depressed that it was difficult to function” at some time in the past year.” About 10 percent of college students have thought seriously about committing suicide or have made a plan to do so.
When we pressure children to achieve, we cut them off from their sources of inspiration, their passions, and their natural curiosity. They don’t grow up to love learning but instead are schooled in how to game tests and make the grade. This does not make their lives meaningful, or happy.
This article is abuot kids that are seriously depressed. This shows that kids are so depressed that thirty percent oif college kids were so depressed they were unable to function properly. Some students have unfortunatley are commiting suicide.
Alcohol severely damages your liver causing fatty liver disease which increases the chance of obesity. People as young as thirty were needing liver transplants and inflamation to the liver was starting as young as twenty.
The doctor said ,any of the patients did not know that alcohol could do so much damage.