Sequencing is getting cheaper, more accessible, and faster. With that, applications for patient care and public health work ( surveillance, outbreak detection, source tracing, virulence mapping) is becoming realistic. What does it take to bring NGS within reach of public health workers across the globe? I am interested in linking the scientific advances in the field of NGS and topics where their application may be of added value
Widespread infection outbreaks pose biggest detection challenge Family Practice News Digital Network VIENNA – Widespread foodborne infectious-disease outbreaks pose the greatest challenge for detection, according to an analysis of 101 U.S.
"he advent of next-generation sequencing technologies is accompanied with the development of many whole-genome sequence assembly methods and software, especially for de novo fragment assembly. Due to the poor knowledge about the applicability and performance of these software tools, choosing a befitting assembler becomes a tough task. Here, we provide the information of adaptivity for each program, then above all, compare the performance of eight distinct tools against eight groups of simulated datasets from Solexa sequencing platform...."
Whole genome sequencing (WGS) promises to be transformative for the practice of clinical microbiology, and the rapidly falling cost and turnaround time mean that this will become a viable technology in diagnostic and reference laboratories in the near future. The objective of this article is to consider at a very practical level where, in the context of a modern diagnostic microbiology laboratory, WGS might be cost-effective compared to current alternatives. We propose that molecular epidemiology performed for surveillance and outbreak investigation and genotypic antimicrobial susceptibility testing for microbes that are difficult to grow represent the most immediate areas for application of WGS, and discuss the technical and infrastructure requirements for this to be implemented.
PubMed comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Marion Koopmans's insight:
position paper on potential impact of next generation sequencing for clinical and public health labs
HPCwire (blog) Federal Agencies Get Guidance On New Data-Sharing Mandate HPCwire (blog) More of that data will find its way into the hands of the public and entrepreneurs thanks to the government's new data sharing mandate, and this month, the...
More than 20 years ago, the discovery of billions of viruses in the oceans was big news, worthy of articles in Nature1 and on the front page of the Washington Post. A year later another Naturereport was published, this time about the most abundant bacterial group in the oceans, cryptically called SAR11. The two stories now come together in a paper published on Nature's website today. Zhao et al. describe DNA viruses that they call 'pelagiphages' and which infect laboratory-grown representatives of SAR11 bacteria. The authors use genomic-sequence data to argue that pelagiphages are among the most abundant viruses in the oceans and perhaps the entire biosphere. The report ends long-running speculation about SAR11, but prompts new questions about marine viruses and the control of microbes in the oceans.
Loman NJ, Misra RV, Dallman TJ, Constantinidou C, Gharbia SE, Wain J, Pallen MJ.
Three benchtop high-throughput sequencing instruments are now available. The 454 GS Junior (Roche), MiSeq (Illumina) and Ion Torrent PGM (Life Technologies) are laser-printer sized and offer modest set-up and running costs.
Sharing your scoops to your social media accounts is a must to distribute your curated content. Not only will it drive traffic and leads through your content, but it will help show your expertise with your followers.
How to integrate my topics' content to my website?
Integrating your curated content to your website or blog will allow you to increase your website visitors’ engagement, boost SEO and acquire new visitors. By redirecting your social media traffic to your website, Scoop.it will also help you generate more qualified traffic and leads from your curation work.
Distributing your curated content through a newsletter is a great way to nurture and engage your email subscribers will developing your traffic and visibility.
Creating engaging newsletters with your curated content is really easy.