Next Gen Sequencing (NGS) and Bioinformatics at UVic
5.5K views | +0 today
Follow
Next Gen Sequencing (NGS) and Bioinformatics at UVic
Your new post is loading...
Your new post is loading...
Scooped by Chris Upton + helpers
Scoop.it!

Analyzing complex plant genomes with the newest next-generation DNA sequencing techniques | Science Codex

Analyzing complex plant genomes with the newest next-generation DNA sequencing techniques | Science Codex | Next Gen Sequencing (NGS) and Bioinformatics at UVic | Scoop.it
Analyzing complex plant genomes with the newest next-generation DNA sequencing ... - Science Codex: Science Code...
more...
No comment yet.
Scooped by Nik Veldhoen
Scoop.it!

DNA: An introduction to nanopore sequencing - Analytes and Applications: DNA, RNA, proteins - Technology - Oxford Nanopore Technologies

"Strand sequencing" is a technique that passes intact DNA polymers through a protein nanopore, sequencing in real time as the DNA translocates the pore. Oxford Nanopore intends to commercialise this technology independently within 2012.

more...
No comment yet.
Scooped by Nik Veldhoen
Scoop.it!

RNA-Seq Atlas – A reference database for gene expression profiling in normal tissue by next generation sequencing

RNA-Seq Atlas – A reference database for gene expression profiling in normal tissue by #NGSeq / #RNASeq = #awesome http://t.co/4IACsepF...
more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

Sequencing set to alter clinical landscape : Nature News & Comment

Sequencing set to alter clinical landscape : Nature News & Comment | Next Gen Sequencing (NGS) and Bioinformatics at UVic | Scoop.it
Access to whole genomes shifts potential for diagnosis, but poses challenges for doctors and regulators.
more...
No comment yet.
Rescooped by Chris Upton + helpers from bioinf
Scoop.it!

Challenges of sequencing human genomes

Massively parallel sequencing technologies continue to alter the study of human genetics. As the cost of sequencing declines, next-generation sequencing (NGS) instruments and datasets will become increasingly accessible to the wider research community. Investigators are understandably eager to harness the power of these new technologies. Sequencing human genomes on these platforms, however, presents numerous production and bioinformatics challenges. Production issues like sample contamination, library chimaeras and variable run quality have become increasingly problematic in the transition from technology development lab to production floor. Analysis of NGS data, too, remains challenging, particularly given the short-read lengths (35–250 bp) and sheer volume of data. The development of streamlined, highly automated pipelines for data analysis is critical for transition from technology adoption to accelerated research and publication. This review aims to describe the state of current NGS technologies, as well as the strategies that enable NGS users to characterize the full spectrum of DNA sequence variation in humans.


Via Mohamed Nadhir Djekidel
more...
No comment yet.
Scooped by Nik Veldhoen
Scoop.it!

Movies - News - Oxford Nanopore Technologies

Movies - News - Oxford Nanopore Technologies | Next Gen Sequencing (NGS) and Bioinformatics at UVic | Scoop.it
Oxford Nanopore videos look nice http://t.co/65nERTN1 will the proprietary protein nanopores & processive enzyme work?
more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

Artemis: an integrated platform for visualization and analysis of high-throughput sequence-based experimental data

High-throughput sequencing (HTS) technologies have made low-cost sequencing of large numbers of samples commonplace. An explosion in the type, not just number, of sequencing experiments has also taken place including genome re-sequencing, population-scale variation detection, whole transcriptome sequencing and genome-wide analysis of protein-bound nucleic acids.

more...
No comment yet.
Scooped by Chris Upton + helpers
Scoop.it!

Performance comparison and evaluation of software tools for microRNA deep-sequencing data analysis

With the development of next-generation sequencing (NGS) techniques, many software tools have emerged for the discovery of novel microRNAs (miRNAs) and for analyzing the miRNAs expression profiles. An overall evaluation of these diverse software tools is lacking. In this study, we evaluated eight software tools based on their common feature and key algorithms.

 

more...
No comment yet.