- Addictive drugs alter synaptic plasticity in the VTA through a common mechanism.
- Changes in the VTA are permissive for later mesocorticolimbic circuit remodeling.
- Mesocorticolimbic circuit remodeling may underlie addiction-related behaviors.
- Reversing drug-induced plasticity may ultimately suppress addiction-related behavior.
by Creed MC & Lüscher C, Current Opinion in Neurobiology, online 6 April 2013