The alterations of Ca2+/calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia | Neuroscience_topics |
  • CaM was up-regulated in the hippocampus of both APP/PS1 mice and VD gerbils.
  • The expression of CaV1.2 protein was increased in VD gerbils and in cultured neurons but decreased in APP/PS1 mice.
  • The number of CaMKII and CaV1.2 co-localization positive neurons was decreased in AD and VD models.

    (...) - by Min D et al., Neuroscience LettersIn Press, Corrected Proof, Available online 8 February 2013