- A better understanding of the role of chemokines and their receptors in the CNS in addition to the immune system.
- This review focuses on recent data about three couples CXCL12/CXCR4, CCL2/CCR2, and CX3CL1/CX3CR1 in the adult CNS.
- Description of their cellular expression, distributions, and roles in neurotransmission and neuromodulation.
- This review summarizes current evidence on the role of these chemokine systems in the pathogenesis of CNS disorders.
by Réaux-Le Goazigo A. et al., Progress in Neurobiology, In Press, Available online 27 February 2013