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Neuroscience_topics
Neuroscience: CNS disease, pain, brain research, ion channels, synaptic transmission, channelopathies, neuronal network
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Scooped by Julien Hering, PhD
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Current status of chemokines in the adult CNS

Current status of chemokines in the adult CNS | Neuroscience_topics | Scoop.it

Highlights

  • A better understanding of the role of chemokines and their receptors in the CNS in addition to the immune system.
  • This review focuses on recent data about three couples CXCL12/CXCR4, CCL2/CCR2, and CX3CL1/CX3CR1 in the adult CNS.
  • Description of their cellular expression, distributions, and roles in neurotransmission and neuromodulation.
  • This review summarizes current evidence on the role of these chemokine systems in the pathogenesis of CNS disorders.

by Réaux-Le Goazigo A. et al.Progress in Neurobiology, In Press, Available online 27 February 2013


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[Review] Kynurenines in the CNS: recent advances and new questions

[Review] Kynurenines in the CNS: recent advances and new questions | Neuroscience_topics | Scoop.it

Various pathologies of the central nervous system (CNS) are accompanied by alterations in tryptophan metabolism. The main metabolic route of tryptophan degradation is the kynurenine pathway; its metabolites are responsible for a broad spectrum of effects, including the endogenous regulation of neuronal excitability and the initiation of immune tolerance. This Review highlights the involvement of the kynurenine system in the pathology of neurodegenerative disorders, pain syndromes and autoimmune diseases through a detailed discussion of its potential implications in Huntington's disease, migraine and multiple sclerosis. The most effective preclinical drug candidates are discussed and attention is paid to currently under-investigated roles of the kynurenine pathway in the CNS, where modulation of kynurenine metabolism might be of therapeutic value. - by Vécsei L et al.Nature Reviews Drug Discovery 1264-82 (January 2013) | doi:10.1038/nrd3793

Julien Hering, PhD's insight:

Interesting review about the kynurenine system invovled in neurodegenerative disorders, pain syndromes and autoimmune disease in CNS. 

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