Selective and regulated gene expression in murine Purkinje cells by in utero electroporation | Neuroscience_technics | Scoop.it

A new in utero electroporation (IUE) protocol has been developed to deliver genes preferentially into cerebellar Purkinje cells. IUE did not alter the physiological characteristics or normal synaptic plasticity of Purkinje cells. IUE allowed selective, effective, and temporally regulated expression of multiple foreign genes in Purkinje cells in vivo. (...) by Nishiyama J et al.European Journal of Neuroscience, Volume 36Issue 7pages 2867–2876October 2012