Neuroscience drug discovery
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Lovastatin corrects excess protein synthesis and prev... [Neuron. 2013] - PubMed - NCBI

Many neuropsychiatric symptoms of fragile X syndrome (FXS) are believed to be a consequence of altered regulation of protein synthesis at synapses. We discovered that lovastatin, a drug that is widely prescribed for the treatment of high cholesterol, can correct excess hippocampal protein synthesis in the mouse model of FXS and can prevent one of the robust functional consequences of increased protein synthesis in FXS, epileptogenesis. These data suggest that lovastatin is potentially disease modifying and could be a viable prophylactic treatment for epileptogenesis in FXS.

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University launches new degree course in drug discovery - This is Nottingham

University launches new degree course in drug discovery - This is Nottingham | Neuroscience drug discovery | Scoop.it
University launches new degree course in drug discovery
This is Nottingham
THE University of Nottingham is to launch a new degree course focussed on discovering new drugs and medicines.
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Technique to create transparent brains could transform neuroscience - The Verge

Technique to create transparent brains could transform neuroscience - The Verge | Neuroscience drug discovery | Scoop.it
National Geographic Technique to create transparent brains could transform neuroscience The Verge A team of chemical engineers and neuroscientists at Stanford University collaborated on the new federally-funded technique, known as CLARITY, which...
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Rescooped by Prasad Joshi from Papers
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Mind-expanding: America’s neuroscience initiative

Mind-expanding: America’s neuroscience initiative | Neuroscience drug discovery | Scoop.it

AFTER much trailing, the reality is out. On April 2nd President Barack Obama announced that America’s government will back a project intended to unlock the mysteries of the human brain. It was, according to the trails, to have been known as the Brain Activity Map. But someone clearly spotted that BAM, as an acronym, is a hostage to fortune and the project is now to be known as the Brain Research through Advancing Innovative Neurotechnologies initiative. By what is no doubt a complete coincidence, that spells “BRAIN”.


Via Ashish Umre, Complexity Digest
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Kasia Hein-Peters's curator insight, April 5, 2013 6:22 PM

I am curious what we will learn through the BRAIN project and I have high hopes.

Rescooped by Prasad Joshi from Natural Products Chemistry Breaking News
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Applicability of a Blood–Brain Barrier Specific Artificial Membrane Permeability Assay at the Early Stage of Natural Product-Based CNS Drug Discovery

Applicability of a Blood–Brain Barrier Specific Artificial Membrane Permeability Assay at the Early Stage of Natural Product-Based CNS Drug Discovery | Neuroscience drug discovery | Scoop.it

While numerous natural products (NPs) possess activity on central nervous system (CNS) targets, there has been no analytical approach to effectively identify compounds with high brain penetration potential in complex mixtures at the early stage of drug discovery. To overcome this issue, the performance of an in vitro parallel artificial membrane permeability assay for the blood–brain barrier (PAMPA-BBB) for natural products and for plant extracts has been validated and characterized. It was found that the PAMPA-BBB assay preserves its predictive power in the case of natural products and provides high phytochemical selectivity, which enables its use as a unique filtering tool in terms of selecting brain-penetrable compounds from plant extracts. Moreover, the present study has demonstrated that simple modifications in the assay design allow the direct use of PAMPA-BBB filtered samples in a dereplication process, as performed by NMR and LC-MS. The applicability of this procedure was demonstrated using extracts prepared from Tanacetum parthenium, Vinca major, Salvia officinalis, and Corydalis cava, representing different types of chemical diversity and complexity. Thus, the proposed protocol represents a potentially valuable strategy in the NP-based CNS drug discovery environment with a high-throughput screening platform.

 

Árpád Könczöl†, Judit Müller†‡, Emília Földes‡, Zoltán Béni§, Krisztina Végh, Ágnes Kéry, and György T. Balogh

J. Nat. Prod., Article ASAP

DOI: 10.1021/np300882f

Publication Date (Web): April 8, 2013


Via NatProdChem
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