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:: American Autoimmune Related Diseases Association, Inc ::

:: American Autoimmune Related Diseases Association, Inc :: | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Information about autoimmunity and autoimmune related diseases. The American Autoimmune Related Diseases Association.

Via Gilbert Faure au nom de l'ASSIM
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Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases
Role of dysfunctional neuro-hormonal-immune interface in immune/inflammatory-related diseases
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Studies prove low fat and low saturated fat diet to be bad for health

Studies prove low fat and low saturated fat diet to be bad for health | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it

The mantra that saturated fat is bad for you and must be removed to reduce the risk of heart disease has been drummed into public consciousness for almost four decades. But independent scientific evidence shows that this advice has paradoxically increased our cardiovascular risk. And the obsession with total cholesterol levels has led to the over- medication of millions with statins with yet more harm than benefit.


Recent prospective cohort studies have not supported any significant association between saturated fat intake and cardiovascular risk. If anything, saturated fat has been found to be protective in many studies. 


Current government guidelines on dietary fat are not supported by independent evidence from randomized control trials.


First, there is no association between heart disease, blood cholesterol and dietary fat; and a meta-analysis of the RCTs available at the time the first guidelines were introduced confirmed that there was no relationship between dietary fat intake and deaths from CHD or all-causes, despite significant reduction in cholesterol levels in the intervention and control groups.  


Second, low fat diets (in accordance with government guidelines) are actually bad for health in comparison with low carbohydrate, low glycaemic diets of the same calorific content.


Third, independent population studies showed that while low cholesterol level is a significant risk factor for cardiovascular and non-cardiac mortality in healthy individuals, high cholesterol level is not.


Finally, the advice to specifically increase omega-6 PFUAs intake may actually increase the risks of CHD and death. 


In view of this evidence on the lack of association between heart disease, blood cholesterol and dietary fat, the mass medication of healthy people with cholesterol lowering statins has resulted in yet more harm than good (see  Statins for the Healthy are Harmful ).





Via Sepp Hasslberger
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Sepp Hasslberger's curator insight, April 13, 11:06 AM

All those "low fat" and "diet" products on the supermarket shelves ... stay away from them. They are actually BAD for you!

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Low Magnesium Hardens Arteries - Newsmax

Low Magnesium Hardens Arteries - Newsmax | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
In one study that used experimental animals, magnesium supplementation inhibited the deposit of lipids in the walls of the aorta — that is, it inhibited plaque formation, a major factor in atherosclerosis.
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High Blood Interferon-γ Levels Linked to the Early Phase of Chronic Fatigue Syndrome

High Blood Interferon-γ Levels Linked to the Early Phase of Chronic Fatigue Syndrome | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
A study published in the February issue of the new journal Science Advances is perhaps the first to identify distinct stages of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
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Deficiency of IL-10 in Chronic Fatigue Syndrome?

Deficiency of IL-10 in Chronic Fatigue Syndrome? | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Chronic fatigue syndrome/myalgic encephalomyelitis, an illness characterized by unexplained fatigue lasting 6 months or more, is often linked to dysfunctional neuroendocrine and immune responses, including abnormal production of several cytokines...
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Chronic Fatigue Syndrome Study Findings May Lead to Diagnostic Tool - New York Times

Chronic Fatigue Syndrome Study Findings May Lead to Diagnostic Tool - New York Times | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Scientists have found biomarkers for chronic fatigue syndrome that may eventually form the basis of the first diagnostic test for it.
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Immune System Changes Tied to Chronic Fatigue Syndrome

Immune System Changes Tied to Chronic Fatigue Syndrome | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
The study adds to growing evidence that chronic fatigue syndrome is caused by a malfunctioning immune system...
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Likelihood of MS, Other Autoimmune Disorders in Women Increased By Mercury ... - Multiple Sclerosis News Today

Likelihood of MS, Other Autoimmune Disorders in Women Increased By Mercury ... - Multiple Sclerosis News Today | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
This study suggests mercury exposure by seafood may increase the risk to develop autoimmune disease in women.
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Research shows strong ties between gum disease and cancer - The Times of Israel

Research shows strong ties between gum disease and cancer - The Times of Israel | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
‘Troublemaking’ bacteria that is a major factor in periodontitis prevents the body from properly fending off cancerous cells, Hebrew U research shows
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Using Parasites to Fight Autoimmune Diseases - IsraCast

Using Parasites to Fight Autoimmune Diseases - IsraCast | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Using Parasites to Fight Autoimmune Diseases
IsraCast
According to Dr.
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New Evidence Indicates that Oxytocin Deficiency May Represent a Biomarker of Anxiety in Children

New Evidence Indicates that Oxytocin Deficiency May Represent a Biomarker of Anxiety in Children | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Recent evidence indicates that oxytocin is an anxiolytic hormone, as it decreases the release of stress hormones, while oxytocin imbalances have been associated with both anxiety (HJ Lee et al., Prog Neurobiol, 2009, 88:127) and depression.
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Macrophage Activation May be the Cause of Acute Exacerbation of Idiopathic ... - Pulmonary Hypertension News

Macrophage Activation May be the Cause of Acute Exacerbation of Idiopathic ... - Pulmonary Hypertension News | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Read more about how Macrophage Activation may be the cause of Acute Exacerbation of Idiopathic Pulmonary Fibrosis
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Autoimmune Disease Diagnostics Market Forecasted To Be Worth $14.17 Billion ... - GlobeNewswire (press release)

Autoimmune Disease Diagnostics Market Forecasted To Be Worth $14.17 Billion ... - GlobeNewswire (press release) | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
San Francisco, California, Dec. 16, 2014 (GLOBE NEWSWIRE) -- Global autoimmune disease diagnostics market is
expected to reach USD 14.17 billion by 2020, according to a new
study by Grand View Research, Inc.
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Proinflammatory cytokines and DHEA-S in women with fibromyalgia: im... - PubMed - NCBI

J Pain Res. 2014 Dec 4;7:707-16. doi: 10.2147/JPR.S71344. eCollection 2014.
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Unraveling the Hygiene Hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications

Unraveling the Hygiene Hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it

In this review, we will dissect the microbial actors thought to be involved in the HH as well as their immunomodulatory mechanisms as emphasized by experimental studies, with a particular attention on parasites. Thereafter, we will review the early clinical trials using helminthes’ derivatives focusing on autoimmune diseases.


Via Alfredo Corell
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Alfredo Corell's curator insight, April 15, 6:29 PM

Background

The Hygiene Hypothesis (HH) attributes the dramatic increase in autoimmune and allergic diseases observed in recent decades in Western countries to the reduced exposure to diverse immunoregulatory infectious agents. This theory has since largely been supported by strong epidemiological and experimental evidence.



BMC Medicine 2015, 13:81  doi:10.1186/s12916-015-0306-7

The electronic version of this article is the complete one and can be found online at:http://www.biomedcentral.com/1741-7015/13/81

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Anti-inflammation genes linked to longer lives - Science News

Anti-inflammation genes linked to longer lives - Science News | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Inflammation-dampening genes fight oxidants and promote longer life spans.
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Fighting Inflammation, the Body's Hidden Killer - Men's Journal

Fighting Inflammation, the Body's Hidden Killer - Men's Journal | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Right now you could be at war with persistent low-grade inflammation, a condition that often goes undiagnosed but wreaks havoc on the body.
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Glucocorticoid Resistance of Th17 Cells in Takayasu Arteritis

Glucocorticoid Resistance of Th17 Cells in Takayasu Arteritis | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Takayasu arteritis (TA) is a rare type of vasculitis that affects mostly middle-aged women, with greater frequency in Asia, South America and the Mediterranean countries.
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Chronic fatigue a real measurable illness, say researchers - CTV News

Chronic fatigue a real measurable illness, say researchers - CTV News | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Researchers say they have found 'unequivocal' evidence that chronic fatigue syndrome is not an imaginary illness, but a genuine condition that causes the immune system to go into overdrive, leaving patients feeling perpetually exhausted.
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Drinking Coffee May Halt Multiple Sclerosis: How Many Cups Should You Drink? - Medical Daily

Drinking Coffee May Halt Multiple Sclerosis: How Many Cups Should You Drink? - Medical Daily | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Dietary factors, such as coffee consumption, may influence disease activity in MS by stopping it in its tracks.
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How Feelings of Awe Lower Inflammation

How Feelings of Awe Lower Inflammation | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
A new study shows how art, nature and spirituality may prevent disease.
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Long Term Use of Common Anticholinergic Drugs Linked To High Risk of Dementia

Long Term Use of Common Anticholinergic Drugs Linked To High Risk of Dementia | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
A recent  British Medical Journal study indicated that there is a dose-effect relation between benzodiazepine use and the increased risk of Alzheimer’s disease.
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Common medications can lead to dementia in the elderly, says study - ModVive

ModVive
Common medications can lead to dementia in the elderly, says study
ModVive
Acetylcholine is the primary neurotransmitter in the parasympathetic system.
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Gut microbes may trigger autoimmune disease later in life - Economic Times

Gut microbes may trigger autoimmune disease later in life - Economic Times | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
The scientists showed that approximately one quarter of mice modified in this way spontaneously developed antibodies that would attack components of the cell nucleus.
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Is depression a kind of allergic reaction?

Is depression a kind of allergic reaction? | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Caroline Williams: A growing number of scientists are suggesting that depression is a result of inflammation caused by the body’s immune system
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High Neonatal Monocyte Chemotactic Protein-1 (MCP-1) Levels May Represent an Early Marker of Autism

High Neonatal Monocyte Chemotactic Protein-1 (MCP-1) Levels May Represent an Early Marker of Autism | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Immune dysregulation and markers of inflammation have been associated with Autism Spectrum Disorder (ASD).
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