Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases
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Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases
Role of dysfunctional neuro-hormonal-immune interface in immune/inflammatory-related diseases
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97% of Terminal Cancer Patients Previously Had Root Canal Procedure

Do you have a chronic degenerative disease? If so, have you been told, “It’s all in your head?” Well, that might not be that far from the truth… the root cause of your illness may bein your mouth.
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Interleukin-33 Reverses Cognitive Deficits in Alzheimer’s Mouse Model Showing Promise as a Therapeutic Target

Interleukin-33 Reverses Cognitive Deficits in Alzheimer’s Mouse Model Showing Promise as a Therapeutic Target | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
A new study published in the Proceedings of the National Academy of Sciences USA (PNAS) indicates that interleukin-33 (IL-33) is able to improve memory deficits and reduce the accumulation of β-amyloid in APP/PS1 mice that exhibit Alzheimer’s...
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Activated Microglia Polarizes γδ T Cells towards a Neurotoxic IL-17+ γδ T Cell Phenotype

Activated Microglia Polarizes γδ T Cells towards a Neurotoxic IL-17+ γδ T Cell Phenotype | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
New study showing that activated microglia via TLRs shifts of the T cells’ profile towards a neurotoxic IL-17+ γδ T cells phenotype
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Gum disease link to Alzheimer's, research suggests - BBC News

Gum disease link to Alzheimer's, research suggests - BBC News | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Gum disease is linked with a greater rate of cognitive decline for people with Alzheimer's Disease, research suggests.
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Etiology of autism spectrum disorders: Genes, environment, or both?OA Autism

Etiology of autism spectrum disorders: Genes, environment, or both?OA Autism | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
New scientific findings how vaccine ingredient aluminum alters gene expression for immune and neuronal signaling https://t.co/TyToQd0Gp8
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The secret to staying sharp in old age? Brushing your teeth!

The secret to staying sharp in old age? Brushing your teeth! | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Gum disease activates the immune system, triggering the release of chemicals that cause inflammation thought to damage the brain, King's College London and University of Southampton experts said.
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How immune cells protect against Alzheimer's disease...

How immune cells protect against Alzheimer's disease... | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
University of California, Irvine scientists revealed B-cells and T-cells, which are immune cells located outside of the brain, help microglia - immune cells in the brain - in getting rid of the plaques that build up to cause Alzheimer's.
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Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms

Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present a perspective that statins may be causative in coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and ‘heme A’, and thereby ATP generation. 
 
Statins inhibit the synthesis of vitamin K2, the cofactor for matrix Gla-protein activation, which in turn protects arteries from calcification. 
 
Statins inhibit the biosynthesis of selenium containing proteins, one of which is glutathione peroxidase serving to suppress peroxidative stress. An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure, reminiscent of the dilated cardiomyopathies seen with selenium deficiency. 
 
Thus, the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs. 
 

Via Sepp Hasslberger
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Sepp Hasslberger's curator insight, January 28, 7:49 PM

As a friend said, and I agree,

"If anyone has a relative on statins try to get them off them, they cause dementia, nerve damage, shakes and mitochondrial muscle failure which leads to heart failure. 

We waste billions on a drug that kills our older generation. 


"The most popular type of statin has been atorvastatin, which has the brand name Lipitor. It has topped the list of highest expenditure drugs on the PBS for the last decade, costing Australian taxpayers more than $7 billion in total, which has gone to Pfizer, the company holding its patent." 


The Japanese are onto it finally... 


Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms"

 

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An Association between Widespread Pain and Serum IL-8 Levels in Fibromyalgia Patients

An Association between Widespread Pain and Serum IL-8 Levels in Fibromyalgia Patients | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Pro-inflammatory cytokines, such as interleukin (IL)-17A might be involved in the development of fibromyalgia (FM).
Ozdolap S, et al.
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Swedish diagnostic method for Alzheimer´s becomes international standard - HealthCanal.com (press release) (blog)

Swedish diagnostic method for Alzheimer´s becomes international standard - HealthCanal.com (press release) (blog) | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it

“ Swedish diagnostic method for Alzheimer´s becomes international standard”

 

After decades of research, Henrik Zetterberg and Kaj Blennow at Sahlgrenska Academy, Gothenburg University, were able to develop a method that measures the exact amount of beta amyloid in spinal fluid and diagnose Alzheimer’s ten to thirty years before the disease becomes symptomatic.

 

The global reference method is established by the global platform, the Joint Committee for Traceability in Laboratory Medicine (JCTLM), whose goal is to promote and provide guidance on equivalent, internationally recognized and accepted measurements within laboratory medicine. JCTLM is a collaboration between three global, standardizing institutions: The International Committee for Weights and Measures (CIPM), International Federation for Clinical Chemistry and Laboratory Medicine (IFCC), and the International Laboratory Accreditation Cooperation (ILAC).


Via Krishan Maggon , Uston News
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Krishan Maggon 's curator insight, October 29, 2015 10:02 AM

Researchers at Gothenburg University have developed a reference method for standardized measurements that diagnose Alzheimer’s disease decades before symptoms appear. The method has now formally been classified as the international reference method, which means that it will be used as the standard in Alzheimer’s diagnostics worldwide.

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Rainer Straub and the Origin of Chronic Inflammatory Systemic Diseases

Rainer Straub and the Origin of Chronic Inflammatory Systemic Diseases | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Synopsis of the Book The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae, by Rainer H Straub, Academic Press/Elsevier Chronic inflammatory systemic diseases (CIDs) are a burden to humans because approximately 10% of the...
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Discovery Could Lead to Better Recovery After Stroke

Discovery Could Lead to Better Recovery After Stroke | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Researchers have identified a molecule that signals brain tissue to form new connections to compensate for damage following a stroke.

Via iPamba, Pamela D Lloyd
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Pamela D Lloyd's curator insight, October 28, 2015 4:01 PM

Welcome news for future stroke sufferers and their families. My mother suffered a massive stroke from which she never fully recovered, making the last ten years of her life difficult ones. I sincerely hope that the prospects for recovery will improve.

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Could Depression Be Caused By An Infection? - NPR

Could Depression Be Caused By An Infection? - NPR | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Infection and autoimmune activity result in inflammation. And psychiatric researchers now suspect that inflammation may play a role in some cases of depression and other mental illnesses.
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Immune cells may act as ‘trash compactors’ to fight Alzheimer’s

Immune cells may act as ‘trash compactors’ to fight Alzheimer’s | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Inflammation, once seen as problem, might actually help slow the disease, new study finds
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Neurologist Warns Aluminum in Chemtrails Could Cause “Explosive Increase in Neurodegenerative Diseases”

Neurologist Warns Aluminum in Chemtrails Could Cause “Explosive Increase in Neurodegenerative Diseases” | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Exposing the climate geoengineering cover-up
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Disruption of Brain TNF Homeostasis Elicits Maladaptive Alterations Producing Chronic Pain - BrainImmune: Trends in Neuroendocrine Immunology

Disruption of Brain TNF Homeostasis Elicits Maladaptive Alterations Producing Chronic Pain - BrainImmune: Trends in Neuroendocrine Immunology | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
An overview on the regulation of brain TNF, norepinephrine release and α2-adrenergic receptors related to neuropathic pain
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Controversial New Push to Tie Microbes to Alzheimer's Disease

Controversial New Push to Tie Microbes to Alzheimer's Disease | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
A journal article says herpes virus and Lyme disease bacteria are behind the mind-robbing illness, but not all researchers are convinced
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IL-17 And Altered Brain Development & Autism-Like Symptoms | The BrainImmune Resource: Opinions & Views In Neuroendocrine Immunology, Stress-immune Interactions

IL-17 And Altered Brain Development & Autism-Like Symptoms | The BrainImmune Resource: Opinions & Views In Neuroendocrine Immunology, Stress-immune Interactions | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Science report indicating that interleukin-17 interferes with brain development in mice, causing disorganized cortical architecture & autism-like symptoms.
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Discovering the Missing Link in Neuropathic Pain - RELIEF: PAIN RESEARCH NEWS, INSIGHTS AND IDEAS

Discovering the Missing Link in Neuropathic Pain - RELIEF: PAIN RESEARCH NEWS, INSIGHTS AND IDEAS | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
A key protein, called CSF1, is released from injured nerve cells to cause activation of the immune system, leading to pain in mice.
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Foxp3+ Treg-derived IL-35 limits anti-tumor T cell immunity | NIHilist's Immunology

Foxp3+ Treg-derived IL-35 limits anti-tumor T cell immunity | NIHilist's Immunology | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it

Treg derived IL-35 limits anti-tumor T cell immunity


Via Gilbert C FAURE
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Gilbert C FAURE's curator insight, February 16, 3:53 AM

In summary, this study indicate the following scenario: certain tumors recruit Tregs. These Tregs secrete IL-35 and inhibit recruitment of effector T cells and/or contributes to their exhaustion. Blocking of IL-35 could provide immunotherapeutic benefit (interestingly, it appears that IL-35 does not synergize with anti-PD1 treatment in tumor models discussed in this paper).

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Th17 and Th22 Cells and Pathogenesis of Guillain-Barré | The BrainImmune Resource: Opinions & views in neuroendocrine immunology, stress-immune interactions

Th17 and Th22 Cells and Pathogenesis of Guillain-Barré | The BrainImmune Resource: Opinions & views in neuroendocrine immunology, stress-immune interactions | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it

New study showing that in Guillain-Barré syndrome circulating Th17, Th22 cells and Th1 cells are increased along with the plasma levels of IL-17 and IL-22.

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Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. - PubMed

Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. - PubMed | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it

In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present a perspective that statins may be causative in coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and 'heme A', and thereby ATP generation.

 

Statins inhibit the synthesis of vitamin K2, the cofactor for matrix Gla-protein activation, which in turn protects arteries from calcification.

 

Statins inhibit the biosynthesis of selenium containing proteins, one of which is glutathione peroxidase serving to suppress peroxidative stress. An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure, reminiscent of the dilated cardiomyopathies seen with selenium deficiency.

 

Thus, the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs.

We propose that current statin treatment guidelines be critically reevaluated. 

 

Via Sepp Hasslberger
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Sepp Hasslberger's curator insight, November 6, 2015 5:53 AM

If you know someone who has been prescribed statin drugs to prevent heart disease, show them this article...

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Links and risks associated with psoriasis and metabolic syndrome - Dove Medical Press

Links and risks associated with psoriasis and metabolic syndrome - Dove Medical Press | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it

Links and risks associated with psoriasis and metabolic syndrome Aikaterini I Liakou, Christos C Zouboulis Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Centre, Dessau, Germany

 

Introduction: Psoriasis has long been considered a systemic inflammatory disease. Lately, it has been strongly associated with obesity, as well as other components of metabolic syndrome, such as dyslipidemia, insulin resistance, and arterial hypertension.
Methods: We reviewed the literature of the last decade by using the keywords: psoriasis, metabolic syndrome, and/or obesity in PubMed and Medline.
Results: Obesity and psoriasis seem to share similar profiles of systemic inflammation. Serum cytokines such as TNF-α, CRP, IL-6, and IL-12 are elevated in both disorders. The more severely an individual is affected with psoriasis, the more likely it is to be obese. This makes the disease an important health care issue, which requires the cooperation of dermatologists with other medical specialists.
Discussion: This review attempts to summarize the links and risks that associate psoriasis with obesity, and highlight the concerns and queries for both disorders in the future.

Keywords: psoriasis, obesity, metabolic, syndrome, inflammation


Via Krishan Maggon
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Krishan Maggon 's curator insight, November 4, 2015 9:28 AM
Links and risks associated with psoriasis and metabolic syndrome
         AbstractMetricsGet Permission

Authors Liakou AI, Zouboulis CC

Received 30 May 2015

Accepted for publication 6 August 2015

Published 2 November 2015 Volume 2015:5 Pages 125—128

DOI http://dx.doi.org/10.2147/PTT.S54089

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ivan Grozdev

Peer reviewer comments 4

Editor who approved publication: Prof. Dr. Uwe Wollina

Uston News's curator insight, November 8, 2015 10:58 AM

ajouter votre perspicacité ...

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New finding will help target MS immune response - EurekAlert (press release)

New finding will help target MS immune response - EurekAlert (press release) | Neuroendocrine-Immune Dysfunction in Inflammatory Human Diseases | Scoop.it
Researchers have made another important step in the progress towards being able to block the development of multiple sclerosis and other autoimmune diseases.
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Do glia drive synaptic and cognitive impairment in disease? - Nature.com

Nature.com
Do glia drive synaptic and cognitive impairment in disease?
Nature.com
Astrocytes actively participate in synaptic transmission and contribute to synaptic plasticity.
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