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Rescooped by Susie Lunardi from Stem Cells & Tissue Engineering
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International Stem Cell Corporation enters into clinical research agreement for Parkinson's Disease program

International Stem Cell Corporation, (ISCO, www.internationalstemcell.com), a California-based biotechnology company developing novel stem cell-based therapies, announced today that it has entered into a master clinical research agreement with Duke University to conduct clinical trials research in Parkinson's disease using ISCO's innovative neural stem cell product.

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Jacob Blumenthal's curator insight, August 28, 2013 4:51 AM

ISCO's Parkinson's disease program uses human parthenogenetic neural stem cells (hPNSC), a novel therapeutic cellular product derived from the company's proprietary histocompatible human pluripotent stem cells. The hPNSC are self-renewing mulitpotent cells that are precursors for the major cells of the central nervous system. The ability of hPNSC to (1) differentiate into dopaminergic neurons and (2) express neurotrophic factors such as glial derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) to protect the nigrostriatal system, offers a new and revolutionary opportunity for the treatment of Parkinson's disease, especially in cases where current dopamine-replacement approaches fail to adequately control the symptoms.

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To learn about the embryonic development of dopaminergic neurons:

http://discovery.lifemapsc.com/in-vivo-development/dopaminergic-neurons


Stem cell differentiation protocols:

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols

Rescooped by Susie Lunardi from Stem Cells & Tissue Engineering
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Japan to start stem-cell study on humans : Nature News Blog

Japan to start stem-cell study on humans : Nature News Blog | neuro-law-gical | Scoop.it

On 1 August, researchers at the RIKEN Center for Developmental Biology in Kobe, Japan, will start recruiting patients for the world's first clinical study using induced pluripotent stem (iPS) cells.


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Jacob Blumenthal's curator insight, August 1, 2013 2:07 AM

Ophthalmologist Masayo Takahashi will be using sheets of retinal pigment epithelium (RPE) cells, derived from iPS cells, to try to halt the progression of age-related macular degeneration. In the wet-type AMD targeted by Takahashi, abnormal vascularization invades and destabilizes the epithelium, which supports the photoreceptors, and causes loss of vision.

To learn more about stem cells differentiation protocols towards retina cells, photoreceptors and RPE:

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols


Rescooped by Susie Lunardi from Stem Cells & Tissue Engineering
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Efficient model for generating human induced pluripotent stem cells

Efficient model for generating human induced pluripotent stem cells | neuro-law-gical | Scoop.it

Researchers at the University of California, San Diego School of Medicine report a simple, easily reproducible RNA-based method of generating human induced pluripotent stem cells (iPSCs) in the August 1 edition of Cell Stem Cell. Their approach has broad applicability for the successful production of iPSCs for use in human stem cell studies and eventual cell therapies.


Via Jacob Blumenthal
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Jacob Blumenthal's curator insight, August 2, 2013 6:16 AM

Researchers from UCSD report on  a simple, highly reproducible RNA-based iPSC generation approach that utilizes a single, synthetic self-replicating VEE-RF RNA replicon that expresses four reprogramming factors (OCT4, KLF4, and SOX2, with c-MYC or GLIS1) at consistent high levels prior to regulated RNA degradation. A single VEE-RF RNA transfection into newborn or adult human fibroblasts resulted in efficient generation of iPSCs with all the hallmarks of stem cells, including cell surface markers, global gene expression profiles, and in vivo pluripotency, to differentiate into all three germ layers.

 http://www.cell.com/cell-stem-cell/abstract/S1934-5909(13)00259-2

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To learn more about stem cells and differentiation protocols:

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols

http://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells


Rescooped by Susie Lunardi from Stem Cells & Tissue Engineering
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Reprogramming Stem Cells Directly in the Brain - The Dana Foundation


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Jacob Blumenthal's curator insight, July 15, 2013 11:19 AM

Researchers from Lund University have developed a method to induce cell reprogramming in-vivo. They designed reprogramming genes that could be activated or deactivated using the drug doxycycline. They inserted these genes into fibroblasts in the laboratory and then injected these  cells into living rats. Then they put the activating drug through in the animals’ drinking water.The result was reprogramming of the fibroblasts into neurons inside the brain.

Although this is not a new and recent paper, it describes a fascinating method: http://www.pnas.org/content/110/17/7038.long