Herein is an overview of our observations on the inhibition of the induction of splenic CD4 and CD8+ regulatory T cells, thymic and hepatic regulatory T cells by the ablation of the sympathetic nervous system by the neurotoxin 6-hydroxydopamine (6-OHDA).
We suggest that the sympathetic influence on the activation and maintenance of different regulatory T cells is a major neuronal influence of the immune system that could be a major factor in chronic stress.
LinkedIn has announced it is launching a new Linkedin Contacts that aims to create a “personal assistant” for users.
You might be thinking you already have a Contacts section in your LinkedIn account – and you’d be right. However, this goes well beyond what LinkedIn offers today under the “Contacts” tab. The new LinkedIn Contacts will reside within LinkedIn and also as a standalone app for iPhone.
What’s new about it? With the new LinkedIn Contacts you will be able to see information not only about your LinkedIn connections, but also everybody in your address book, calendars and emails. You can have all your professional contacts in one place, instead of scattered around among LinkedIn, email, and other places.
On the official LinkedIn blog, Engineer and Product Specialist Sachin Rekhi writes:
“LinkedIn Contacts brings together all your address books, emails, and calendars, and keeps them up to date in one place. From these sources, we’ll automatically pull in the details of your past conversations and meetings, and bring these details directly onto your contact’s profile.”
(...) - By Joshua Sophy, Small Business Trends, April 29, 2013
Among the growing number of molecules known to be involved in both neuronal and immune modulation, Nerve Growth Factor (NGF) seems to have a role in this complex network of bi-directional signals between the nervous and immune systems.
Cognitive impairment in ME/CFS linked to reduced vagus nerve control of heart ...ProHealthCognitive impairment in ME/CFS linked to reduced vagus nerve control of heart rate. (1 votes). ProHealth.com • November 15, 2012.
Vagus Nerve Stimulation for Rheumatoid Arthritis: Interview with Anthony Arnold, CEO of SetPoint Medical. SetPoint Medical is dedicated to treating patients with debilitating inflammatory diseases, such as Crohn's Disease ...
Vagus nerve and unconsciousness are linked all the way through an automatic feedback identified as vasovagal syncope. A normally skilled situation which is nothing but vasovagal syncope is at times known as vasovagal ...
Afferent vagal pathways transmit information to the brain related to peripheral inflammation so as to participate in the activation of adaptive reactions, including fever and sickness behavior. On the other side, efferent vagal pathways inhibit the synthesis and release of pro-inflammatory cytokines by peripheral immune cells. Because activation of afferent vagal pathways by immune stimuli leads to suppression of immune reactions, the term inflammatory reflex was introduced.
The vagus nerve connects the brain to several parts of the digestive system. It's what tells your brain how hungry you are, based on what it senses in your belly. The vagus nerve has also been shown to carry signals initiated by bacteria.
In this study, Laurence Macia and colleagues from the Garvan Institute of Medical Research, Darlinghurst, Australia, demonstrate that NPY exacerbates allergic airway inﬂammation (AAI) in mice, via its Y1 receptor. They found that the development of AAI was associated with elevated NPY expression in the lung and that mice lacking Y1 receptor signaling have signiﬁcantly reduced symptoms of AAI.
In this recent perspective, Michael Irwin and Steven Cole from the Cousins Center for Psychoneuroimmunology discuss a third class of stimulus, in the form of neural and endocrine signals, resulting from macroenvironmental sensing, and its involvement in the reciprocal regulation of neural–immune circuits.
An integral component of your braking system is your vagus nerve, a far-flung nerve that reaches nearly all the organs of your body. It slows down your breathing and your heart rate and modulates your voice.
Gayatri Devi MD is a neurologist and the Director of the New York Memory Services. She is a Clinical Associate Professor at the New York University School of Medicine.
I am reading her book outloud to my wife about 10 pages at a time. It is calming our brains. I have become a fan of hers, because she really knows what she is talking about, has a holistic approach that does not abandon good science, and tells her truth like a very interesting story.
Leukocytes are key components of the body’s defense system and the major subsets of leukocytes are granulocytes and lymphocytes.
We and others have found that the distribution of these subsets are under the regulation of the autonomic nervous system. Of note, granulocytes express adrenergic receptors and the number and proportion of granulocytes increase by a stimulation of the sympathetic nervous system.
Primary and secondary lymphoid organs are innervated by the autonomic nervous system resulting in release of catecholamines, acetylcholine and peptide transmitters (neuropeptide Y-NPY, substance P-SP, calcitonin gene-related peptide-CGRP and vasoactive intestinal peptide-VIP) in the lymphoid microenvironment. Noradrenergic and neuropeptidergic nerve fibers are found adjacent to cells of the immune system in thymus and spleen regulating the immune responsiveness, lymphocyte cellular functions, collective cellular interactions as well as the overall host immunological response.
Forbes Top 10 Challenges for Brain Science in 2013 Forbes Neuroscience, behavioral science, evolutionary biology, economics, engineering, and even the humanities have all come to the proverbial table in the last few years.
To investigate the role of neuroendocrine activation in cancer progression, in this study, Erica K. Sloan and colleagues used in vivo bioluminescence imaging to track the development of metastasis in an orthotopic mouse model of breast cancer. The authors demonstrate that physical restraint, applied as a standardized stressor increased the metastasis of primary breast tumor cells to distant tissues by 38-fold, and stress increased metastasis in clinically relevant tissues, with a 37-fold increase in the lung and a 67% increase in the lymph nodes.
Is there a role for vagus nerve stimulation therapy as a treatment of traumatic brain injury? July 5, 2012. Although this data unequivocally shows that VNS improves outcome from TBI in animal models, it remains to be determined if these ...
The human nervous system exerts great influence on the homeostasis of the body; this includes regulation of bone marrow processes like hematopoiesis. Tachykinins are small neuropeptides from 10-12 amino acids long synthesized in various nuclei of the central nervous system such as the substania gelatinosa of the dorsal spinal cord and certain nuclei of the limbic lobes as well as in a number of non-neuronal tissues like stromal cells of the BM. Within the bone marrow, the tachykinins have been shown to have critical effects on the microenvironment, including metastasis and dormancy of cancer cells during clinical remission.
"Our research and that of other scientists suggest that activation of the vagus nerve is associated with feelings of caretaking and the ethical intuition that humans from different social groups (even adversarial ones) share a common humanity."
In this recent study, George Slavich and colleagues from the University of California, Los Angeles demonstrate that a social stressor involving social-evaluative threat and rejection elicits signiﬁcant increases in inﬂammatory activity, as indexed by both soluble receptor for tumor necrosis factor-alpha (sTNFalphaRII) and interleukin (IL)-6.
The vagus nerve is a bundle of nerves that originates in the top of the spinal cord. It activates different organs throughout the body (such as the heart, lungs, liver and digestive organs). When active, it is likely to produce that ...
Here is a summary of effects of vagus nerve stimulation that corroborates the bits and pieces of info I have been collecting on this "systemic" function in the body/mind whole.