We've known big data has had big impacts in business, and in lots of prediction tasks. I want to understand, what does big data mean for what we do for science? Specifically, I want to think about the following context: You have a scientist who has a hypothesis that they would like to test, and I want to think about how the testing of that hypothesis might change as data gets bigger and bigger. So that's going to be the rule of the game. Scientists start with a hypothesis and they want to test it; what's going to happen?