While cells in many brain regions cells are responsive to reward, the cortical-basal ganglia cir-cuit is at the heart of the reward system. The key structures in this network are: the anteriorcingulate cortex, the orbital prefrontal cortex, the ventral striatum, the ventral pallidum, andthe midbrain dopamine neurons. In addition, other structures including the dorsal prefrontalcortex, amygdala, hippocampus, thalamus, lateral habenular n., and specific brainstem struc-tures, such as the pedunculopontine n. and the raphe n., are key components in regulatingthe reward circuit. Connectivity between these areas forms a complex neural network that istopographically organized, thus maintaining functional continuity through the cortico-basalganglia pathway. However, the reward circuit does not work in isolation. The network alsocontains specific regions in which convergent pathways provide an anatomical substrate forintegration across functional domains.