Organic synthesis
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Miniaturization of NMR Systems: Desktop Spectrometers, Microcoil Spectroscopy, and “NMR on a Chip” for Chemistry, Biochemistry, and Industry - Chemical Reviews

Miniaturization of NMR Systems: Desktop Spectrometers, Microcoil Spectroscopy, and “NMR on a Chip” for Chemistry, Biochemistry, and Industry - Chemical Reviews | Organic synthesis | Scoop.it
Sergey S. Zalesskiy†, Ernesto Danieli‡, Bernhard Blümich*‡, and Valentine P. Ananikov*†§† Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia‡ Institut für Technische Chemie und Makromolekulare Chemie, RWTH Aachen University, Worringerweg 1, D-52074 Aachen, Germany§ Department of Chemistry, Saint Petersburg State University, Stary Petergof, 198504, RussiaChem. Rev., Article ASAPDOI: 10.1021/cr400063gPublication Date (Web): April 29, 2014
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Rescooped by Zhengao Feng from Natural Products Chemistry Breaking News
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On-Line Reaction Monitoring and Mechanistic Studies by Mass Spectrometry: Negishi Cross-Coupling, Hydrogenolysis, and Reductive Amination

On-Line Reaction Monitoring and Mechanistic Studies by Mass Spectrometry: Negishi Cross-Coupling, Hydrogenolysis, and Reductive Amination | Organic synthesis | Scoop.it
Keywords:air-/moisture-sensitive reactions;cross-coupling;mass spectrometry;reaction intermediates;reaction kineticsAbstract

Reaction monitoring using inductive ESI mass spectrometry allows chemical reactions to be tracked in real time, including air- and moisture-sensitive as well as heterogeneous reactions. Highly concentrated solutions can also be monitored for long periods without emitter clogging. Sheath gas assists in nebulization and a sample splitter reduces the delay time and minimizes contamination of the instrument. Short-lived intermediates (ca. 5 s) were observed in Pd/C-catalyzed hydrogenolysis, and several intermediates were seen in Negishi cross-coupling reactions.

 

Xin Yan, Ewa Sokol, Dr. Xin Li, Guangtao Li, Dr. Shiqing Xu andProf. R. Graham Cooks*
Angewandte Chemie International Edition

Early View (Online Version of Record published before inclusion in an issue)

 

Article first published online: 17 APR 2014

DOI: 10.1002/anie.201310493

 

 


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