Nanotechnology & Health
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a collection of articles about nanomaterials and health
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The tiniest particles that may be a threat as bad as asbestos

The tiniest particles that may be a threat as bad as asbestos | Nanotechnology & Health | Scoop.it

Europe is failing to control a burgeoning industry in microscopic materials, prompting claims that it has failed to heed the lessons from millions of asbestos deaths, according to a hard-hitting new report... A major study published by the European Environment Agency (EEA) last week says European governments – including the UK's – are "paralysed by analysis" and failing to act: "Twenty years have elapsed since first indications of nanomaterial harm were published", it said, "and in the intervening time an increasing body of literature has been developed on how nanomaterials interact with cells, mammals and aquatic organisms. Yet many governments still call for more information as a substitute for action."

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The comparative immunotoxicity of mesoporous silica nanoparticles and colloidal silica nanoparticles in mice

The comparative immunotoxicity of mesoporous silica nanoparticles and colloidal silica nanoparticles in mice | Nanotechnology & Health | Scoop.it
Results: There was no overt sign of clinical toxicity in either MPS- or Col-treated mice. However, MPS NPs led to significant increases in liver and spleen weight and splenocyte proliferation. Mice treated with MPS NPs showed altered lymphocyte populations (CD3+, CD45+, CD4+, and CD8+) in the spleen, increased serum IgG and IgM levels, and histological changes. Despite slight changes in lymphocyte populations in the spleen, Col NPs did not alter other immunological factors.
Conclusion: The results indicate that in vivo exposure to MPS NPs caused more damage to systemic immunity than that of Col NPs through the dysregulation of the spleen. The results for in vivo data are inconsistent with those for in vitro data, which show lower cytotoxicity for MPS NPs. These results suggest the importance of verifying biocompatibility both in vitro and in vivo during the design of new nanomaterials.
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