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The top 100 papers: NATURE magazine explores the most-cited research papers of all time

The top 100 papers: NATURE magazine explores the most-cited research papers of all time | Nanotechnology | Scoop.it

The discovery of high-temperature superconductors, the determination of DNA’s double-helix structure, the first observations that the expansion of the Universe is accelerating — all of these breakthroughs won Nobel prizes and international acclaim. Yet none of the papers that announced them comes anywhere close to ranking among the 100 most highly cited papers of all time.


Citations, in which one paper refers to earlier works, are the standard means by which authors acknowledge the source of their methods, ideas and findings, and are often used as a rough measure of a paper’s importance. Fifty years ago, Eugene Garfield published the Science Citation Index (SCI), the first systematic effort to track citations in the scientific literature. To mark the anniversary, Nature asked Thomson Reuters, which now owns the SCI, to list the 100 most highly cited papers of all time. (See the full list at Web of Science Top 100.xls or the interactive graphic, below.) The search covered all of Thomson Reuter’s Web of Science, an online version of the SCI that also includes databases covering the social sciences, arts and humanities, conference proceedings and some books. It lists papers published from 1900 to the present day.


The exercise revealed some surprises, not least that it takes a staggering 12,119 citations to rank in the top 100 — and that many of the world’s most famous papers do not make the cut. A few that do, such as the first observation1 of carbon nanotubes (number 36) are indeed classic discoveries. But the vast majority describe experimental methods or software that have become essential in their fields.


The most cited work in history, for example, is a 1951 paper2 describing an assay to determine the amount of protein in a solution. It has now gathered more than 305,000 citations — a recognition that always puzzled its lead author, the late US biochemist Oliver Lowry.


Via Dr. Stefan Gruenwald
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So you want to be a computational biologist? : Nature Biotechnology : Nature Publishing Group

Two computational biologists give advice when starting out on computational projects.

Via Pedro Fernandes
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Pedro Fernandes's curator insight, November 10, 2013 2:21 PM

Well done @pathogenomenick and  @biomickwatson

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New device harnesses sun and sewage to produce hydrogen fuel

New device harnesses sun and sewage to produce hydrogen fuel | Nanotechnology | Scoop.it
A novel device that uses only sunlight and wastewater to produce hydrogen gas could provide a sustainable energy source while improving the efficiency of wastewater treatment.
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New test to diagnose cancer in minutes - Derby Telegraph

Derby Telegraph
New test to diagnose cancer in minutes
Derby Telegraph
All items are free next day delivery. www.myprint-247.co.uk ...
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DNA nanotechnology - sensing applications and drug release

DNA nanotechnology - sensing applications and drug release | Nanotechnology | Scoop.it
DNA/nanoparticle hybrid systems hold great promise for the development of new sensing platforms, the programmed organization of nanoparticles, the switchable control of plasmonic phenomena in the nanostructures, and the controlled delivery of drugs.
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Nanoparticle vaccine: Particles that deliver vaccines directly to mucosal surfaces could defend against many infectious diseases

Nanoparticle vaccine: Particles that deliver vaccines directly to mucosal surfaces could defend against many infectious diseases | Nanotechnology | Scoop.it
Many viruses and bacteria infect humans through mucosal surfaces, such as those in the lungs, gastrointestinal tract and reproductive tract.
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Nanotechnology in plant disease management - Nanowerk

Nanotechnology in plant disease management - Nanowerk | Nanotechnology | Scoop.it
Nanowerk
Nanotechnology in plant disease management
Nanowerk
(Nanowerk News) Nanotechnology has been found to be highly useful in medical diagnostics, drug delivery, tissue engineering, etc.
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Nanotechnology lecture by Richard Feynman

A nanotechnology lecture by Richard Feynman from the 80s in which he foresees the future and the world to come in exploring nano particles and the very small!

Via Muditha Senarath Yapa
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web-based course on "#NANOTECHNOLOGY & #NANOSENSORS"

web-based course on "#NANOTECHNOLOGY & #NANOSENSORS" | Nanotechnology | Scoop.it
We are a social entrepreneurship company that partners with the top universities in the world to offer courses online for anyone to take, for free.

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DNA nanorobots find and tag cellular targets - Nanotechnology News (press release)

DNA nanorobots find and tag cellular targets - Nanotechnology News (press release) | Nanotechnology | Scoop.it
DNA nanorobots find and tag cellular targets Nanotechnology News (press release) Though other DNA nanorobots have been designed to deliver drugs to cells, the advantage of Stojanovic's fleet is its ability to distinguish cell populations that do...
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\'Smart\' nanoparticles designed to improve drug delivery, DNA self-assembly

\'Smart\' nanoparticles designed to improve drug delivery, DNA self-assembly | Nanotechnology | Scoop.it
A team of chemists in SU's College of Arts and Scientists has used a temperature-sensitive polymer to regulate DNA interactions in both a DNA-mediated assembly system and a DNA-encoded drug-deliver ('Smart' nanoparticles designed to improve drug delivery,...
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A microchip implant for women containing 16 years of contraceptives ready for pre-clinical trials next year

A microchip implant for women containing 16 years of contraceptives ready for pre-clinical trials next year | Nanotechnology | Scoop.it

Women may soon bid farewell to birth control pills and welcome a new type of contraception in the form of microchip implants. An MIT startup backed by the Bill Gates Foundation plans to start pre-clinical testing for the birth control chip next year and pave the way for a possible market debut in 2018.

 

The fingernail-size microchip implant holds enough 30-microgram daily doses of levonorgestrel—a hormone already used in several contraceptives—to last for 16 years. Women who received the implant under the skin of buttocks, upper arm or abdomen would also get a remote control that allows them to halt or restart the implant whenever they like, according to MIT Technology Review.

 

MicroCHIPS, the MIT startup behind the birth control implant, developed a clever design for a titanium and platinum seal that temporarily melts when an internal battery sends an electric charge running through the seal. That lasts just long enough for the melted seal to release the daily dose of levonorgestrel from the microchip reservoirs.

 

The microchip technology's latest mission first came about when Bill Gates visited the MIT lab of Robert Langer and challenged researchers to come up with a birth control method that women could control themselves and would also last for many years. Langer, an MIT professor who already holds 1,050 patents worldwide, thought of using the controlled release microchip technology that he and his colleagues had developed in the 1990s.

 

MicroCHIPS had previously demonstrated how the microchip technology could release daily doses of an osteoporosis drug during human clinical trials detailed in the 16 Feb 2012 online edition of the journal Science Translational Medicine. The new application for the microchips—each measuring 20 x 20 x 7 millimeters—could potentially revolutionize the level of control women have over their birth control technologies.

 

The biggest difference that the MicroCHIPS technology brings comes from giving women control over starting and stopping birth control regimens that can otherwise work for years without requiring regular attention. By comparison, existing contraceptive implants require a trip to the local clinic or hospital for removal if a woman wants to stop using the implant.

 

Any device offering wireless control for its users also runs the risk of being hacked. But Robert Farra, president and CEO of MicroCHIPS, told BBC Newsthat their technology included secure encryption to prevent outsiders from blocking or reprogramming the implants wirelessly. As an added precaution, the remote control can only communicate with the microchip implant across a distance equivalent to skin contact.


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UC Develops Intelligent Nano Carrier to Target Drug Delivery to Cancer Cells

UC Develops Intelligent Nano Carrier to Target Drug Delivery to Cancer Cells | Nanotechnology | Scoop.it

University of Cincinnati researchers have developed the first-of-its-kind nanostructure which is unusual because it can carry a variety of cancer-fighting materials on its double-sided (Janus) surface and within its porous interior.

 

Because of its unique structure, the nano carrier can do all of the following:

 

• Transport cancer-specific detection nanoparticles and biomarkers to a site within the body, e.g., the breast or the prostate. This promises earlier diagnosis than is possible with today’s tools. 

 

• Attach fluorescent marker materials to illuminate specific cancer cells, so that they are easier to locate and find for treatment, whether drug delivery or surgery. 

 

• Deliver anti-cancer drugs for pinpoint targeted treatment of cancer cells, which should result in few drug side effects. Currently, a cancer treatment like chemotherapy affects not only cancer cells but healthy cells as well, leading to serious and often debilitating side effects.

 

This recently developed Janus nanostructure is unusual in that, normally, these super-small structures (that are much smaller than a single cell) have limited surface. This makes is difficult to carry multiple components, e.g., both cancer detection and drug-delivery materials. The Janus nanocomponent, on the other hand, has functionally and chemically distinct surfaces to allow it to carry multiple components in a single assembly and function in an intelligent manner.
 
“In this effort, we’re using existing basic nano systems, such as carbon nanotubes, graphene, iron oxides, silica, quantum dots and polymeric nano materials in order to create an all-in-one, multidimensional and stable nano carrier that will provide imaging, cell targeting, drug storage and intelligent, controlled drug release,” said UC’s Shi, adding that the nano carrier’s promise is currently greatest for cancers that are close to the body’s surface, such as breast and prostate cancer.


Via Dr. Stefan Gruenwald
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Adrian Vallejo Blanco's curator insight, November 2, 2013 1:16 PM

Una nanoestructura como nave nodriza para vehiculizar drogas y marcadores contra células tumorales. Esta estructura posee una superficie de doble cara y un espacio interior hueco donde alberga la droga.

 

En su superficie, puede transportar anclados varios complejos como marcadores fluorescentes junto con receptores específicos para señales características de un tipo concreto de tumor, de modo que cuando la molécula se ancla a la célula cancerígena sea capaz de liberar la droga y no solo eso, sino emitir fluorescencia marcando y delimitando la masa tumoral facilitando tanto el diagnóstico como hasta una posible cirugía.

 

Una gran ventaja aparte de que la masa tumoral pueda ser delimitada y señalizada con fluorescencia, es que la droga contra las células cancerosas sea liberada justo en esas células cancerosas afectando así minimamente a las células sanas. Actualmente con la radio y quimioterapia se ataca a las células tumorales pero las sanas son gravemente debilitadas.

Alexis Meneses Arévalo's curator insight, November 3, 2013 6:26 AM

DALCAME

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Cells prefer nanodiscs over nanorods

Cells prefer nanodiscs over nanorods | Nanotechnology | Scoop.it
For years scientists have been working to fundamentally understand how nanoparticles move throughout the human body. One big unanswered question is how the shape of nanoparticles affects their entry into cells.
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Nanotechnology Documentary the Quantum Computer science and the technology behind it

Nanotechnology documentary on the quantum computing science and the technology behind it.
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Nanoparticles: Tracking protein corona over time

Nature Nanotechnology.
doi:10.1038/nnano.2013.196
Author: Martin Lundqvist
Protein corona form rapidly around nanoparticles mixed with human plasma and can affect nanoparticle pathophysiology.
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Turning plastic bags into high-tech materials

Turning plastic bags into high-tech materials | Nanotechnology | Scoop.it
Researchers have developed a process for turning waste plastic bags into a high-tech nanomaterial.
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Nanotechnology Now - Press Release: "New system uses ...

Nanotechnology Now - Press Release: "New system uses ... | Nanotechnology | Scoop.it
Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed an innovative drug-delivery system in which tiny particles called nanodiamonds are used to carry chemotherapy drugs directly into brain tumors.
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TEDxCaltech - Mark E. Davis - Nanomedicines: Nanobiotech v. Cancer

Mark E. Davis is the Warren and Katharine Schlinger Professor of Chemical Engineering at Caltech and a member of the Experimental Therapeutics Program of the...


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Precision delivery of synthetic vaccines using DNA scaffolds ...

Precision delivery of synthetic vaccines using DNA scaffolds. When reading about nanomedicine, one is struck by the focus on precision especially with the regard to drug delivery and other therapeutics.

Via Luís Bastos
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Eucalyptus macrocarpa is giving nano-medicine a boost - Phys.Org

Eucalyptus macrocarpa is giving nano-medicine a boost - Phys.Org | Nanotechnology | Scoop.it
Eucalyptus macrocarpa is giving nano-medicine a boost
Phys.Org
"Gold nanoparticles have proven to be very versatile across a range of treatments, including in the delivery of double-stranded DNA in the emerging gene therapy area," Dr Poinern said.
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