My Library
49 views | +0 today
Follow
Your new post is loading...
Your new post is loading...
Scooped by Xianglei WU
Scoop.it!

FDA Approves Imlygic, First Oncolytic Viral Therapy in the US

FDA Approves Imlygic, First Oncolytic Viral Therapy in the US | My Library | Scoop.it
The FDA has given the green light to talimogene laherparepvec for the treatment of advanced melanoma, making it the first oncolytic viral therapy to be approved for sale in the United States.
Xianglei WU's insight:

The DRR was significantly higher among patients receiving the experimental drug than among those given GM-CSF (16.3% vs 2.1%; odds ratio, 8.9; P < .001). Of the patients who experienced a durable response, 29.1% had a durable complete response and 70.8% had a durable partial response. The median time to response was 4.1 (range: 1.2 to 16.7) months in the arm receiving talimogene laherparepvec.

The overall response rate was also higher with talimogene laherparepvec (26.4% vs 5.7%; P < .001). In all, 32 (10.8%) patients receiving talimogene laherparepvec experienced a complete response, compared with just one (< 1%) patient receiving GM-CSF.

 

The median time to treatment failure was 8.2 months with talimogene laherparepvec and 2.9 months with GM-CSF (hazard ratio [HR], 0.42). Median overall survival was 23.3 months and 18.9 months, respectively (HR, 0.79; P = .051), which just missed being statistically significant.

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

HCV Guideline Update: Treat All Patients With New Drugs

HCV Guideline Update: Treat All Patients With New Drugs | My Library | Scoop.it
An update has suggested that all patients, with the exception of patients with short life expectancies not related to HCV, should be treated with newer HCV medications.
more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations

Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations | My Library | Scoop.it
Xianglei WU's insight:

A very distinctive and insightful point.

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency — NEJM

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency — NEJM | My Library | Scoop.it
Original Article from The New England Journal of Medicine — PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
Xianglei WU's insight:

This study showed that mismatch-repair status predicted clinical benefit of immune checkpoint blockade with pembrolizumab, which might explain the variable response rate of this treatment through genetic view.

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

JCI - Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis

Xianglei WU's insight:

Together, these results indicate that the prognostic impact of T cell infiltrates for CRC maybe largely based on subpopulations of active TA-specific T cells within the tumor, suggesting causal implication for these cells in patient survival. Additionally, these results support the use of intratumoral TNF-α, which is indicative of T cell function, as a prognostic parameter for CRC.

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

US vs European Physicians: Their Ethical Differences. Medscape Ethics Report 2014

US and European physicians have some fascinating differences in medical and patient ethics, as revealed in Medscape's Ethics Report.
Xianglei WU's insight:

American doctors seemingly more abide by rules, especially legal ones, but the European emphasis more on ethics and human relations.

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer

Xianglei WU's insight:

Combining antigen-producing A1-R with αPD-L1 blocking antibody enhanced the expansion of tumor-specific CD8+ T cells and resulted in 80% tumor rejection.

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

JCI - Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis

these results indicate that the prognostic impact of T cell infiltrates for CRC maybe largely based on subpopulations of active TA-specific T cells within the tumor, suggesting causal implication for these cells in patient survival. Additionally, these results support the use of intratumoral TNF-α, which is indicative of T cell function, as a prognostic parameter for CRC.
more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

Neighborhood poverty, urban residence, race/ethnicity, and asthma: Rethinking the inner-city asthma epidemic - Journal of Allergy and Clinical Immunology

Xianglei WU's insight:

They found Black or Puerto Rican children had far higher asthma rates, at 17% and 20%, respectively, compared with white children (10%), other Hispanic children (9%) and Asian children (8%).

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

GI Needle Biopsies Do Not Spread Cancer, Study Suggests

GI Needle Biopsies Do Not Spread Cancer, Study Suggests | My Library | Scoop.it
Outcomes are no worse in pancreatic cancer patients who undergo fine-needle aspiration than in those who do not, a new study has found.
more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

Persistence of EBV Antigen-Specific CD8 T Cell Clonotypes during Homeostatic Immune Reconstitution in Cancer Patients

Persistence of EBV Antigen-Specific CD8 T Cell Clonotypes during Homeostatic Immune Reconstitution in Cancer Patients | My Library | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
Xianglei WU's insight:

Data suggest that the EBV-specific T cell repertoire persists not only under steady-state conditions but also during transient immunological perturbations.

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

Potential Blood-based Markers of Celiac Disease

Potential Blood-based Markers of Celiac Disease | My Library | Scoop.it
How could blood-based diagnostics help to simplify the process of diagnosing celiac disease, and to aid clinicians in treating the disease?
more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

Screening for Occult Cancer in Unprovoked Venous Thromboembolism — NEJM

Screening for Occult Cancer in Unprovoked Venous Thromboembolism — NEJM | My Library | Scoop.it
Unprovoked venous thromboembolism may be the earliest sign of cancer4,5; up to 10% of patients with unprovoked venous thromboembolism receive a diagnosis of cancer in the year after their diagnosis of venous thromboembolism.6 More than 60% of occult cancers are diagnosed shortly after the diagnosis of unprovoked venous thromboembolism.6 Thereafter, the incidence rate of cancer diagnosis gradually declines and returns to the rate in the general population after 1 year.
more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

TB Now Ranks With AIDS as a Leading Cause of Death Worldwide

TB Now Ranks With AIDS  as a Leading Cause of Death Worldwide | My Library | Scoop.it
The worldwide TB rate has dropped by half since 1990, but the world still needs to ramp up its efforts to halt deaths from the curable disease, according to a new WHO report.
more...
No comment yet.
Rescooped by Xianglei WU from from Flow Cytometry to Cytomics
Scoop.it!

Diversity of assessing circulating tumor cells (CTCs) emphasizes need for standardization: a CTC Guide to design and report trials - Online First - Springer

Diversity of assessing circulating tumor cells (CTCs) emphasizes need for standardization: a CTC Guide to design and report trials - Online First - Springer | My Library | Scoop.it

Via Gilbert C FAURE
Xianglei WU's insight:

Une bonne résumé concernant l'étude des CTCs 

more...
No comment yet.
Rescooped by Xianglei WU from from Flow Cytometry to Cytomics
Scoop.it!

CELLSEARCH® System chosen as platform for new research on PD-L1 and ... - PR Newswire (press release)

RARITAN, N.J., July 8, 2015 /PRNewswire/ -- Janssen Diagnostics today announced that its CELLSEARCH® System...

Via Gilbert C FAURE
more...
Gilbert C FAURE's curator insight, July 11, 2015 11:14 AM

"I believe we have demonstrated that CTC characterization for PD-L1 expression is feasible using a CTC platform. This paves the way for the utilization of a CTC/PD-L1 assay in future clinical trials to explore whether it can stratify patients according to response, and potentially predict the efficacy of immune checkpoint blockade," comments study investigator Catherine Alix-Panabieres, Ph.D., Director of the Laboratory of Rare Human Circulating Cells, University Medical Centre of Montpellier, University of Montpellier EA2415, Montpellier, France. 

Scooped by Xianglei WU
Scoop.it!

When blood transfusion medicine becomes complicated due to interference by monoclonal antibody therapy | Read by QxMD

When blood transfusion medicine becomes complicated due to interference by monoclonal antibody therapy | Read by QxMD | My Library | Scoop.it
Xianglei WU's insight:

Rappel très important.

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

Role of p53 as a prognostic factor for survival in lung cancer: a systematic review of the literature with a meta-analysis

Xianglei WU's insight:

A classical meta article about the prognostic.

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

The Prevalence of Congenital Hearing Loss in Neonates with Down Syndrome - The Journal of Pediatrics

Xianglei WU's insight:

Newborns with Down syndrome have a higher prevalence of congenital hearing loss compared with the total neonatal population (15% vs 0.25%). Continued monitoring of hearing is needed in children with Down syndrome.

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

Phenotypic and Functional Characterization of Herpes Simplex Virus Glycoprotein B Epitope-specific Effector and Memory CD8+ T Cells from Ocular Herpes Symptomatic and Asymptomatic Individuals

(i) healthy ASYMP individuals maintained a significantly higher proportion of differentiated HSV-1 gB-specific effector memory CD8+ T cells (TEM, CD45RAlowCCR7lowCD44highCD62Llow). In contrast, SYMP patients had frequent less-differentiated central memory CD8+ T cells (TCM, CD45RAlowCCR7highCD44lowCD62Lhigh); (ii) ASYMP individuals had significantly higher proportions of multi-functional effector CD8+ T cells, which responded mainly to gB342-350 and gB561-569 “ASYMP” epitopes, and simultaneously produced IFN-γ, CD107a/b, granzyme B and perforin. In contrast, effector CD8+ T cells from SYMP individuals were mostly mono-functional and were directed mainly against non-overlapping gB17-25 and gB183-191 “SYMP” epitopes; (iii) immunization of HLA-A*02:01 transgenic mouse model of ocular herpes with “ASYMP” CD8+ TEM cell epitopes, but not with “SYMP” CD8+ TCM cell epitopes, induced a strong CD8+ T cell-dependent protective immunity against ocular herpes infection and disease.
more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

Sustained Effectiveness of 10kHz High-Frequency Spinal Cord Stimulation for Patients with Chronic, Low Back Pain: 24-Month Results of a Prospective Multicenter Study

Xianglei WU's insight:

In patients with chronic low back pain, HF10 SCS resulted in clinically significant and sustained back and leg pain relief, functional and sleep improvements, opioid use reduction, and high patient satisfaction. These results support the long-term safety and sustained efficacy of HF10 SCS.

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

FDA Approval of 'Novel' New Drugs Up Sharply in 2014

FDA Approval of 'Novel' New Drugs Up Sharply in 2014 | My Library | Scoop.it
The agency credits last year's higher output to various programs designed to speed much needed drugs to market.
more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

Australia Bans Tanning Salons

Australia Bans Tanning Salons | My Library | Scoop.it
A campaign to eliminate 'commercial solariums' is victorious. Could it happen in the United States?
Xianglei WU's insight:

Tanning salon tend to be a fashion in China, especially for men.

more...
No comment yet.
Scooped by Xianglei WU
Scoop.it!

Aztreonam, Carbapenems Safe for Penicillin-Allergic Patients

Aztreonam, Carbapenems Safe for Penicillin-Allergic Patients | My Library | Scoop.it
toztreonam, imipenem-cilastatin, meropenem, or ertapenem.
more...
No comment yet.