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Rescooped by michael bolton from Stem Cells & Tissue Engineering
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Transhumanist Company: Dr. Michael West and BioTime Inc.

Transhumanist Company: Dr. Michael West and BioTime Inc. | Mike's Research | Scoop.it

“BioTime is a biotechnology company focused on the emerging field of regenerative medicine. Our core technologies center on novel stem cells capable of becoming all of the cell types in the human body. Products made from these “pluripotent” stem cells are being developed by our subsidiaries, each of which concentrates on different medical specialties, including: neuroscience, oncology, orthopedics, and blood and vascular diseases. BioTime’s commercial strategy targets near-term commercial opportunities such as Hextend and our current line of research products: ACTCellerate cell lines and associated ESpan culture media, HyStem hydrogels, and GMP human embryonic stem cell lines. In addition, the launch of HyStem-Rx as a cell delivery device is expected in 2013, and the launch of PanC-Dx as a novel blood-based cancer screen is expected by 2014.”

 

 


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Stem cell discovery: Astrocytes could repair stroke brain damage - Medical News Today

Stem cell discovery: Astrocytes could repair stroke brain damage - Medical News Today | Mike's Research | Scoop.it
Stem cell discovery: Astrocytes could repair stroke brain damage Medical News Today Stem cell research has focused until now on developing stroke treatments using therapeutic neurons to stimulate electrical impulses in the brain, and restore tissue...

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Jacob Blumenthal's curator insight, July 29, 2013 8:11 AM

A recent open-access study, published in Nature Communications, suggests that Olig2-positive neuronal progenitors, derived from human embryonic stem cells, can generate a subtype of astcroglia, that have a protective effect. This effect was demonstrated when the cells were transplanted into brains subjected to global ischaemia.

http://www.nature.com/ncomms/2013/130723/ncomms3196/full/ncomms3196.html

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Efficient model for generating human induced pluripotent stem cells

Efficient model for generating human induced pluripotent stem cells | Mike's Research | Scoop.it

Researchers at the University of California, San Diego School of Medicine report a simple, easily reproducible RNA-based method of generating human induced pluripotent stem cells (iPSCs) in the August 1 edition of Cell Stem Cell. Their approach has broad applicability for the successful production of iPSCs for use in human stem cell studies and eventual cell therapies.


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Jacob Blumenthal's curator insight, August 2, 2013 6:16 AM

Researchers from UCSD report on  a simple, highly reproducible RNA-based iPSC generation approach that utilizes a single, synthetic self-replicating VEE-RF RNA replicon that expresses four reprogramming factors (OCT4, KLF4, and SOX2, with c-MYC or GLIS1) at consistent high levels prior to regulated RNA degradation. A single VEE-RF RNA transfection into newborn or adult human fibroblasts resulted in efficient generation of iPSCs with all the hallmarks of stem cells, including cell surface markers, global gene expression profiles, and in vivo pluripotency, to differentiate into all three germ layers.

 http://www.cell.com/cell-stem-cell/abstract/S1934-5909(13)00259-2

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To learn more about stem cells and differentiation protocols:

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols

http://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells


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Reprogramming cells by computer | KurzweilAI

Reprogramming cells by computer | KurzweilAI | Mike's Research | Scoop.it

Scientists at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have developed a model that makes predictions that allow for deciding which differentiated cells — for instance skin cells — can be very efficiently changed into completely different cell types — such as nerve cells, for example.


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Rescooped by michael bolton from Stem Cells & Tissue Engineering
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For Henrietta Lacks' famous cells, new and unique protection

For Henrietta Lacks' famous cells, new and unique protection | Mike's Research | Scoop.it
NEW YORK (Reuters) - Information about the most famous and valuable human cells in the history of science is about to become a little harder for researchers to get.The National Institutes of Health announced (.@NIH reaches agreement with family of...

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Jacob Blumenthal's curator insight, August 8, 2013 1:16 AM

Family relatives of Lacks,  will help decide which biomedical researchers will have access to the complete genome data in cells derived from her cervical tumor, called HeLa cells. That data - which can be used to infer medical and other information about Lacks' family - will be stored in a secure, NIH-controlled database.

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For information about stem cell lines, including gene expression data and related protocols and cell therapies:

http://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells

Rescooped by michael bolton from Cell Therapy & Regenerative Medicine
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Teeth pulp regeneration using stem cells

Teeth pulp regeneration using stem cells | Mike's Research | Scoop.it
Daily Mail Scientists aim to regrow teeth using stem cells Business Standard In the study, the goal of researchers was to test a stem cell-based therapy that would regenerate the dentin-pulp complex and, consequently, totally restore the tooth's...

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Ella Buzhor's curator insight, July 4, 2013 4:34 AM

Stem cell therapy represents a potential strategy to regenerate the dentin-pulp complex, enabling conservation and restoration of teeth. After autologous transplantation of pulp stem cells with G-CSF in a dog pulpectomized tooth, regenerated pulp tissue including vasculature and innervation completely filled in the root canal, and regenerated dentin was formed in the coronal part.

 

http://stemcellstm.alphamedpress.org.rproxy.tau.ac.il/content/2/7/521.abstract

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Reprogrammed cells generate blood vessels

Reprogrammed cells generate blood vessels | Mike's Research | Scoop.it
Harvard researchers have generated long-lasting blood vessels from reprogrammed human cells. The study in the mouse model reveals both the potential and remaining challenges to vessel regeneration.

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Jacob Blumenthal's curator insight, July 16, 2013 1:28 AM

In their report published in  Proceedings of the National Academy Of Sciences (PNAS) early edition, the investigators describe using iPSCs — reprogrammed adult cells that have many of the characteristics of embryonic stem cells — both from healthy adults and from individuals with type 1 diabetes to generate blood vessels on the outer surface of the brain or under the skin of mice (taken from the "Harvard gazette").

http://www.pnas.org/content/early/2013/07/16/1310675110

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Bioteeth From Stemcells Will Regrow Complete Tooth, Superior to Implants

Bioteeth From Stemcells Will Regrow Complete Tooth, Superior to Implants | Mike's Research | Scoop.it
Replacing missing teeth with new bioengineered teeth, grown from stem cells generated from a person's own gum cells, is a new method that will be vastly superior to the currently used implant technology.

Via Ella Buzhor, Jacob Blumenthal
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Stem Cell Discovery Furthers Research on Cell-Based Therapy and Cancer | ucsf.edu

Stem Cell Discovery Furthers Research on Cell-Based Therapy and Cancer | ucsf.edu | Mike's Research | Scoop.it

Stem-cell researchers at UC San Francisco have found a key role for a protein called BMI1 that may help scientists direct the development of tissues to replace damaged organs in the human body.


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Jacob Blumenthal's curator insight, July 26, 2013 3:00 PM

A group of scientists from UCSF, lead by Ophir Klein, MD, PhD, have discovered  a general mechanism whereby BMI1-mediated repression of Hox genes is required for the maintenance of adult stem cells and for prevention of inappropriate differentiation.

http://www.nature.com/ncb/journal/v15/n7/abs/ncb2766.html


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Scientists Announce The Cure For Cancer May Live In The Intestines: Hogwash Or Hope For The Future?

Scientists Announce The Cure For Cancer May Live In The Intestines: Hogwash Or Hope For The Future? | Mike's Research | Scoop.it
A study finds that manipulating stem cells in the intestine can allow mice to tolerate higher levels of chemotherapy and radiation. Could this lead to a cure for cancer?

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Jacob Blumenthal's curator insight, July 31, 2013 3:15 PM

In a paper published today in Nature, the authors tested whether the induction of adult stem cells could repair chemoradiation-induced tissue injury and prolong overall survival in mice. They found that intestinal stem cells (ISCs) expressed Slit2 and its single-span transmembrane cell-surface receptor roundabout 1 (Robo1). During lethal dosages of chemoradiation, administering a short pulse of R-spondin 1 (Rspo1; a Wnt agonist) plus Slit2 reduced ISC loss, mitigated gut impairment and protected animals from death, without concomitantly decreasing tumour sensitivity to chemotherapy. Therefore Rspo1 and Slit2 may act as therapeutic adjuvants to enhance host tolerance to aggressive chemoradiotherapy for eradicating metastatic cancers (from the abstract).

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12416.html

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Cell Stem Cell - Stem Cells in the Face: Tooth Regeneration and Beyond

Cell Stem Cell - Stem Cells in the Face: Tooth Regeneration and Beyond | Mike's Research | Scoop.it

Summary: "The face distinguishes one person from another. Postnatal orofacial tissues harbor rare cells that exhibit stem cell properties. Despite unmet clinical needs for reconstruction of tissues lost in congenital anomalies, infections, trauma, or tumor resection, how orofacial stem/progenitor cells contribute to tissue development, pathogenesis, and regeneration is largely obscure. This perspective article critically analyzes the current status of our understanding of orofacial stem/progenitor cells, identifies gaps in our knowledge, and highlights pathways for the development of regenerative therapies".


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Jacob Blumenthal's curator insight, August 5, 2013 2:50 PM

This is a free review from Cell Stem Cell describing stem cells in the face. It was first published in September 2012, and is now available as part of the Featured Five review collection.

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To learn more about the embryonic development of the head mesenchyme and the bones:

http://discovery.lifemapsc.com/in-vivo-development/head-mesenchyme

http://discovery.lifemapsc.com/in-vivo-development/bone

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For stem cells differentiation protocols:

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols

 

Rescooped by michael bolton from Cell Therapy & Regenerative Medicine
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Stem Cell Treatment Reduces Bone Healing Time By 75%

Stem Cell Treatment Reduces Bone Healing Time By 75% | Mike's Research | Scoop.it
... using stem cells to treat severe fractures can speed up the healing process. The clinical trials that were conducted found that the new treatment shortened the recovery process that normally takes six to 12 months down to two to three months.

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Rescooped by michael bolton from Cell Therapy & Regenerative Medicine
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Anthony Atala: Printing a human kidney | Video on TED.com

Surgeon Anthony Atala demonstrates an early-stage experiment that could someday solve the organ-donor problem: a 3D printer that uses living cells to output a transplantable kidney. Using similar technology, Dr.

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Jacob Blumenthal's curator insight, April 29, 2013 12:30 PM

If you are interested in tissue engineering, regenerative medicine, and bioprinting...this is definitely a MUST SEE presentation!!