Microbes Inside
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Microbes Inside
how the omnipresent nature and function of microbes, including bacteria, archaea and fungi, affects our life
Curated by Clara Belzer
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Cell Metabolism - Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk

Cell Metabolism - Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk | Microbes Inside | Scoop.it
Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk: http://t.co/H0aOO09b #microbiome...

 

Metabolic Axes between Host and the Gut Microbiota are presented, although I miss the barrier of the gut epithelial cells and mucosa that determines what is ending up in the liver in the first place.

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The human gastrointestinal microbiota—An unexplored frontier for pharmaceutical discovery

The human gastrointestinal microbiota—An unexplored frontier for pharmaceutical discovery | Microbes Inside | Scoop.it

It is increasingly apparent that the GIT microbiota plays an intricate role in host health and disease. Targeted strategies for modulating human health through the modification of the GIT microbiota, however, are developing and in their infancy. This perspective article discusses the rationale, benefits and limitations of using the GIT microbiota as a pharmacological and nutritional target in the treatment of various diseases and disorders linked to imbalances in our microbiota.

Roeselers et. al.,; Pharmacological Research 2012

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The function of our microbiota: who is out there and what do they do?

The function of our microbiota: who is out there and what do they do? | Microbes Inside | Scoop.it

Human microbiota: onset and shaping through life stages and perturbations.

Ottman et. al., 2012 Frontiers in Cellular and Infection Microbiology

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How glycan metabolism shapes the human gut microbiota

How glycan metabolism shapes the human gut microbiota | Microbes Inside | Scoop.it

In this Review, the authors describe how glycans shape the composition of the gut microbiota over various periods of time, the mechanisms by which individual microorganisms degrade these glycans, and potential opportunities to intentionally influence this ecosystem for better health and nutrition.

Koropatkin et. al., Nature Reviews Microbiology 10, 323-335 (May 2012) | doi:10.1038/nrmicro2746

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new bacterial indicators of health state in acute murine colitis

new bacterial indicators of health state in acute murine colitis | Microbes Inside | Scoop.it

The bacterial families Ruminococcaceae, Bacteroidaceae, Enterobacteriaceae, Deferribacteraceae and Verrucomicrobiaceae increased in relative abundance in DSS-treated mice

Berry et. al.,; The ISME Journal (2012) 6, 2091–2106; doi:10.1038/ismej.2012.39

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keystone-pathogen hypothesis holds that certain low-abundance microbial pathogens can orchestrate inflammatory disease by remodelling a normally benign microbiota into a dysbiotic one.

keystone-pathogen hypothesis holds that certain low-abundance microbial pathogens can orchestrate inflammatory disease by remodelling a normally benign microbiota into a dysbiotic one. | Microbes Inside | Scoop.it

Although ETBF secretes a pro-oncogenic toxin (B. fragilis toxin (BFT)), the participation of the colonic microbiota is necessary for colon carcinogenesis. According to the 'alpha-bug' hypothesis, ETBF remodels the colonic microbiota and co-opts this microbial community to induce colon cancer; however, in order for this dysbiosis to trigger tumorigenesis, it is likely that ETBF must be present in combination with particular disease modifiers and in hosts with certain genetic traits. It is currently unclear exactly how ETBF influences and interacts with the colonic microbiota to promote carcinogenesis.

Hajishengallis et. al.,: Nature Reviews Microbiology 10, 717-725 (October 2012) | doi:10.1038/nrmicro2873

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Men’s Offices Have More Bacteria, Study Finds

Men’s Offices Have More Bacteria, Study Finds | Microbes Inside | Scoop.it
A census of workplace microbes found that men’s offices have significantly more than women’s, and offices in New York have more than those in San Francisco.
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Transplanting Gut Microbiota May Protect From Diabetes And Fatty Liver Disease

An exciting presentation at the International Liver Congress (TM) 2012 has revealed that gut microbiota play a contributing role in the development of diabetes and non-alcoholic fatty l...
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Whales | Home

Whales | Home | Microbes Inside | Scoop.it
Scientific American and the Zooniverse present Whales Calls...

not about microbiota but so cool!

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Capturing Single Cell Genomes of Active Polysaccharide Degraders: An Unexpected Contribution of Verrucomicrobia

Capturing Single Cell Genomes of Active Polysaccharide Degraders: An Unexpected Contribution of Verrucomicrobia | Microbes Inside | Scoop.it

These findings shed light on the ecological roles of uncultured Verrucomicrobia and suggest specific taxa as promising bioprospecting targets. The employed method offers a powerful tool to rapidly identify and recover discrete genomes of active players in polysaccharide degradation, without the need for cultivation.

published in PLoS ONE , Martinez-Garcia et. al., 2012

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Gut-on-a-chip takes bellyache out of digestion studies - health - 03 April 2012 - New Scientist

Gut-on-a-chip takes bellyache out of digestion studies - health - 03 April 2012 - New Scientist | Microbes Inside | Scoop.it
Now that our gut has been recreated on a microchip, the days of trying to reproduce its complexity in a Petri dish should be over...
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Enterome Raises €5M to Develop Gut Bacteria-Based Disease and Drug-Response Biomarkers

Enterome Raises €5M to Develop Gut Bacteria-Based Disease and Drug-Response Biomarkers | Microbes Inside | Scoop.it

The Paris-based firm is developing biomarkers and drugs for diseases that feature abnormal gut flora composition. Funds will be used primarily to validate Enterome’s biomarkers and commercialize them as laboratory-developed diagnostic services in the U.S. and EU. The firm also plans to set up collaborations with the pharmaceutical and nutrition industries.

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The microbiota–gut–brain axis: learning from intestinal bacteria?

The microbiota–gut–brain axis: learning from intestinal bacteria? | Microbes Inside | Scoop.it

Rapid and sustained gut–brain communication may confer a significant advantage to the host, as central activation in response to changes in commensals or pathogens would allow better control of gut function and immunity.

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Functional interactions between the gut microbiota and host metabolism

Functional interactions between the gut microbiota and host metabolism | Microbes Inside | Scoop.it

The link between the microbes in the human gut and the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes, is becoming clearer.  The microbial inhabitants of the gut can  influence  metabolic processes, such as energy extraction from food, and should be considered an environmental factor that contributes to obesity and its comorbidities

 

Valentina Tremaroli & Fredrik Bäckhed

Nature489,242–249(13 September 2012)doi:10.1038/nature11552

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Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour | Microbes Inside | Scoop.it

Accumulating data now indicate that the gut microbiota also communicates with the CNS and thereby influences brain function and behaviour.

John F. Cryan & Timothy G. Dinan;

Nature Reviews Neuroscience 13, 701-712 (October 2012) | doi:10.1038/nrn3346

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Cat Microbiomes Stem From Diet - Science News - redOrbit

Cat Microbiomes Stem From Diet - Science News - redOrbit | Microbes Inside | Scoop.it
What grows in the gut, for animals and people, is affected by diet. Beginning at birth, gut microbial colonies, known as gut microbiome, start forming.
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Effect of Breast and Formula Feeding on Gut Microbiota Shaping in Newborns

RT @Era7bioinfo: Effect of breast and formula feeding on gut microbiota shaping in newborns. 

Federica Guaraldi1 and Guglielmo Salvatori: Front. Cell. Inf. Microbio., 16 October 2012 | doi: 10.3389/fcimb.2012.00094

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Can Nutritional Modulation of Maternal Intestinal Microbiota Influence the Development of the Infant Gastrointestinal Tract?

Can Nutritional Modulation of Maternal Intestinal Microbiota Influence the Development of the Infant Gastrointestinal Tract? | Microbes Inside | Scoop.it

 

Thum et. al., The Journal of Nutrition 2012

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Research ban for surgeons after probiotic experiment - New Scientist

Two surgeons have been banned from human research after deliberately infecting brain wounds with bacteria to treat terminal cancer...
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How Gut Bacteria Regulate Happiness in Human

How Gut Bacteria Regulate Happiness in Human | Microbes Inside | Scoop.it
A team of scientists has shown that brain levels of serotonin, the happy hormone, are regulated by the amount of bacteria in the gut during early life.
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Radiolab - Guts

Radiolab - Guts | Microbes Inside | Scoop.it
This hour, we dive into the messy mystery in the middle of us. What's going on down there? And what can the rumblings deep in our bellies tell us about ourselves?

popular science about gut microbiota.

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Nature efforts

Nature efforts | Microbes Inside | Scoop.it

Nature efforts: because you tried so hard for a really long time

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How glycan metabolism shapes the human gut microbiota

How glycan metabolism shapes the human gut microbiota | Microbes Inside | Scoop.it

Fluctuations in the abundance of dietary and endogenous glycans, combined with the immense chemical variation among these molecules, create a dynamic and heterogeneous environment in which gut microorganisms proliferate. In this Review, the authors describe how glycans shape the composition of the gut microbiota over various periods of time, the mechanisms by which individual microorganisms degrade these glycans, and potential opportunities to intentionally influence this ecosystem for better health and nutrition.

Nature Reviews Microbiology 10, 323-335 (May 2012) | doi:10.1038/nrmicro2746

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Scientist Examines Possible Link Between Antibiotics and Obesity

Scientist Examines Possible Link Between Antibiotics and Obesity | Microbes Inside | Scoop.it
A researcher asserts that antibiotics are permanently altering microbial flora of the human body, with unforeseen consequences.
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Influence of Breast Milk Vs. Formula and Genetics on Gut Microbiota Composition Could Help Prevent Celiac Disease | News Room

Influence of Breast Milk Vs. Formula and Genetics on Gut Microbiota Composition Could Help Prevent Celiac Disease | News Room | Microbes Inside | Scoop.it
A team of investigators from Spain shows that the level of genetic risk of celiac disease influences the composition of infants’ gut microbiota, and confirms earlier studies showing that the type of milk feeding—breast vs.
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