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Visionary UI biologist Carl Woese, 84, dies | News-Gazette.com

Visionary UI biologist Carl Woese, 84, dies | News-Gazette.com | Microbes Inside | Scoop.it
Carl Woese, the University of Illinois microbiology professor credited with the discovery of a “third domain” of life, died Sunday at his home in Urbana. He was 84.
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Microbes Inside
how the omnipresent nature and function of microbes, including bacteria, archaea and fungi, affects our life
Curated by Clara Belzer
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FAQ: Human Microbiome, January 2014

FAQ: Human Microbiome, January 2014 | Microbes Inside | Scoop.it
In July 2013, the American Academy of Microbiology convened a panel of experts to help answer common questions people have about the human microbiome.
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Rescooped by Clara Belzer from Microbial World
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Gut microbes linked to improving autism symptoms

Gut microbes linked to improving autism symptoms | Microbes Inside | Scoop.it
"Groundbreaking" research linking gut microbes to autism could lead to a probiotic therapy for improving the symptoms of autism.

Via Guus Roeselers
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Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals | Microbes Inside | Scoop.it
Clara Belzer's insight:

Mucus educate Dendritic Cells to develop tolerance against commensal antigens

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Gut Microbiota World Watch’s first anniversary

Gut Microbiota World Watch’s first anniversary | Microbes Inside | Scoop.it
It has been one year since the launch of our blog. To celebrate it, we would like to share with you an infographics showing the progress and the characteristics of our community.
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Transplanting fecal microbiota from twins discordant for obesity differentially affects metabolic activities in mice

Transplanting fecal microbiota from twins discordant for obesity differentially affects metabolic activities in mice | Microbes Inside | Scoop.it
The team of Jeffrey Gordon (Ridaura et al. Science 2013) published that the phenotype of obesity (increased adiposity) of an obese twin in a discordant twin pair is transmissible.
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The Human Microbiome Gets A Big Pharma Investment - Forbes

The Human Microbiome Gets A Big Pharma Investment - Forbes | Microbes Inside | Scoop.it
The Human Microbiome Gets A Big Pharma Investment Forbes “This is an area of great importance for our R&D strategy for immunology because we believe it can bring in the mid-term and long-term value toward our goal of addressing unmet medical need,”...

Via Gilbert Faure au nom de l'ASSIM
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New immune system discovered - Medical Xpress - Medical Xpress

New immune system discovered - Medical Xpress - Medical Xpress | Microbes Inside | Scoop.it
New immune system discovered - Medical Xpress Medical Xpress "We envision BAM influencing the prevention and treatment of mucosal infections seen in the gut and lungs, having applications for phage therapy and even directly interacting with the...

Via Gilbert Faure au nom de l'ASSIM
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Dmitry Alexeev's curator insight, July 28, 2013 7:33 AM

one of the ways various ways to control that wild kingdom of bacterias inside the gut)

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The Mucus-Lover that Stops Mice from Getting Fat

The Mucus-Lover that Stops Mice from Getting Fat | Microbes Inside | Scoop.it
When Bob Paine chucked starfish into the Pacific Ocean in 1963, he was also throwing bombs into the heart of ecology. Back then, the prevailing view was that communities of animals and plants were ...
Clara Belzer's insight:

one more ;-)

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Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity — Akkermansia muciniphila controls host metabolism

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity — Akkermansia muciniphila controls host metabolism | Microbes Inside | Scoop.it
Clara Belzer's insight:
We recently isolated Akkermansia muciniphila, which is a mucin-degrading bacterium that resides in the mucus layer. The presence of this bacterium inversely correlates with body weight in rodents and humans. This study demonstrated that the abundance of A. muciniphila decreased in obese and type 2 diabetic mice. We demonstrated that A. muciniphila treatment reversed high-fat diet-induced metabolic disorders, including fat-mass gain, metabolic endotoxemia, adipose tissue inflammation, and insulin resistance. A. muciniphila administration increased the intestinal levels of endocannabinoids that control inflammation, the gut barrier, and gut peptide secretion. Everard et al., PNAS 2013
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Ingestible gastrointestinal sampling device

Ingestible gastrointestinal sampling device | Microbes Inside | Scoop.it

MONTREAL, April 26, 2013 /PRNewswire-iReach/ --Micropharma Limited, a pioneer in the development of innovative and effective products based on the human microbiome, today announced that after three years of development it has a timeline for launch of its ingestible gastrointestinal sampling technology.

 

Manipulation of the gut microbiome is becoming an important way to treat immune, gastrointestinal and metabolic disease.  Probiotic therapies affecting the human gut microbiome have gained regulatory approval and are now included as part of clinical guidelines for a wide range of indications.  Further, there are now a number of microbiome focused companies actively developing microbiome based diagnostics, identifying uses for small molecules acting through the microbiome and developing GMO stains to affect the microbiome. 

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Dmitry Alexeev's curator insight, May 10, 2013 7:20 AM

You swallow - it collects the sample along the way - and here it is the microbiota from the inner part of yours) 

Rescooped by Clara Belzer from Systems biology and bioinformatics
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First insights into the metagenome of Egyptian mummies using next-generation sequencing

First insights into the metagenome of Egyptian mummies using next-generation sequencing | Microbes Inside | Scoop.it

Via Dmitry Alexeev
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Dmitry Alexeev's curator insight, April 9, 2013 4:05 AM

mummies - the unbelivable advance into history of metanomes) 

 

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Gut microbiota or gut flora? Prof. Joël Doré explains which term is best

We interviewed Prof.Joël Doré, Head of Research at the French National Institute for Agricultural Research (INRA - Institut National de la Recherche Agronomique), at the 2nd Gut Microbiota for Health Summit, in order to find out more about gut...
Clara Belzer's insight:

I agree we should use the term microbiota to indicate the microorganisms in our intestine because microbes are not teh same as plants . Also be aware that microbiome is not the same as  microbiota. Microbiome is all microorgansims including their genetic content.

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Infographics

Infographics | Microbes Inside | Scoop.it
The ISME Journal promotes diverse and integrated areas of microbial ecology spanning the breadth of microbial life, including bacteria, archaea, microbial eukaryotes, and viruses.
Clara Belzer's insight:

ISMEJ also publishes Microbiota research of high quality

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Manipulation of the Microbiota for Treatment of IBS and IBD—Challenges and Controversies


Via Dmitry Alexeev
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Dmitry Alexeev's curator insight, February 5, 1:13 AM

issues of biota manipulation

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Metabolic niche of a prominent sulfate-reducing human gut bacterium

Metabolic niche of a prominent sulfate-reducing human gut bacterium | Microbes Inside | Scoop.it
Clara Belzer's insight:

Desulfovibrio piger, the most frequent SRB presentin the microbiota

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Dmitry Alexeev's curator insight, November 1, 2013 3:56 AM

lets double check the data accunulated)

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Bacterial colonization factors control specificity and stability of the gut microbiota : Nature : Nature Publishing Group

Bacterial colonization factors control specificity and stability of the gut microbiota : Nature : Nature Publishing Group | Microbes Inside | Scoop.it
Mammals harbour a complex gut microbiome, comprising bacteria that confer immunological, metabolic and neurological benefits.
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Dmitry Alexeev's curator insight, October 22, 2013 1:21 AM

polysaccharide utilization loci found resposible for success of colonization


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Gut Microbes Treat Illness | The Scientist Magazine®

Gut Microbes Treat Illness | The Scientist Magazine® | Microbes Inside | Scoop.it
Oral administration of a cocktail of bacteria derived from the human gut reduces colitis and allergy-invoked diarrhea in mice.
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Early infant growth rate linked to composition of gut microbiota

Early infant growth rate linked to composition of gut microbiota | Microbes Inside | Scoop.it
The composition of gut microbiota in a new-born baby's gut has been linked to the rate of early infant growth.
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A Bug versus Diet-Induced Metabolic Disorders

A Bug versus Diet-Induced Metabolic Disorders | Microbes Inside | Scoop.it

A study at the Université Catholique de Louvain and Wageningen University was recently published in PNAS (Proceedings of the National Academy of Sciences) and has been getting a lot of attention.

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Novel Developmental Analyses Identify Longitudinal Patterns of Early Gut Microbiota that Affect Infant Growth

Novel Developmental Analyses Identify Longitudinal Patterns of Early Gut Microbiota that Affect Infant Growth | Microbes Inside | Scoop.it
PLOS Computational Biology is an open-access
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Gut microbe may fight obesity and diabetes

Gut microbe may fight obesity and diabetes | Microbes Inside | Scoop.it

Bacterium 'Akkermansi muciniphila' helps to regulate metabolism in mice.

Clara Belzer's insight:

Finally I can site my own work again ;-)

This fanthastic bug can reduce weight gain en diabetes type 2 metabolic markers in mice. next step human trials!

also check my scoop on the actual paper in PNAS

Clara

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my.microbes: science for everyone

my.microbes: science for everyone | Microbes Inside | Scoop.it
Peer Bork: send stool sample and €841 and he will analyse your gut microbiota on his HiSeq #ISSAPAC http://t.co/WlLZfidpoY
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Early microbial and metabolomic signatures predict onset of necrotizing enterocolitis in preterm infants

Early microbial and metabolomic signatures predict onset of necrotizing enterocolitis in preterm infants | Microbes Inside | Scoop.it
Necrotizing enterocolitis (NEC) is a devastating intestinal disease that afflicts 10% of extremely preterm infants.
Clara Belzer's insight:
"Early dysbiosis is strongly involved in the pathobiology of NEC. These striking findings require validation in larger studies but indicate that early microbi al and metabolomic signatures may provide highly predictive biomarkers of NEC."Morrowet al.,Microbiome: 2013,1:13 doi:10.1186/2049-2618-1-13
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PLOS ONE: Complex Carbohydrate Utilization by the Healthy Human Microbiome

PLOS ONE: Complex Carbohydrate Utilization by the Healthy Human Microbiome | Microbes Inside | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
Clara Belzer's insight:

When broad sugar utilization was compared within the five major body sites, the gastrointestinal track contained the highest potential for total sugar degradation, while dextran and peptidoglycan degradation were highest in oral and vaginal sites respectively.

 

The analysis suggests that the carbohydrate composition of each body site has a profound influence and probably constitutes one of the major driving forces that shapes the community composition and therefore the CAZyme profile of the local microbial communities, which in turn reflects the microbiome fitness to a body site.

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Dmitry Alexeev's curator insight, April 22, 2013 1:10 PM

as we just start thinking of carb utilization - the issue a paper)