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PrettyCoolWoman CoolingTank and CoolingTunic

PrettyCoolWoman CoolingTank and CoolingTunic | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
Fashionable, effective, non-medical solution to hot flashes and night sweats.
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Support this Indiegigo project with me...it's pretty cool!
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First time ever: Researchers rewrite an entire bacterial genome and add a healthy twist

First time ever: Researchers rewrite an entire bacterial genome and add a healthy twist | metal, wine, beer, yoga, cupcakes & golf | Scoop.it

Scientists from Yale and Harvard have recoded the entire genome of an organism and improved a bacterium’s ability to resist viruses, a dramatic demonstration of the potential of rewriting an organism’s genetic code.

“This is the first time the genetic code has been fundamentally changed,” said Farren Isaacs, assistant professor of molecular, cellular, and developmental biology at Yale and co-senior author of the research published Oct. 18 in the journal Science. “Creating an organism with a new genetic code has allowed us to expand the scope of biological function in a number of powerful ways.”

 

The creation of a genomically recoded organism raises the possibility that researchers might be able to retool nature and create potent new forms of proteins to accomplish a myriad purposes — from combating disease to generating new classes of materials.

 

The research — headed by Isaacs and co-author George Church of Harvard Medical School — is a product of years of studies in the emerging field of synthetic biology, which seeks to re-design natural biological systems for useful purposes.

 

In this case, the researchers changed fundamental rules of biology.

Proteins, which are encoded by DNA’s instructional manual and are made up of 20 amino acids, carry out many important functional roles in the cell. Amino acids are encoded by the full set of 64 triplet combinations of the four nucleic acids that comprise the backbone of DNA. These triplets (sets of three nucleotides) are called codons and are the genetic alphabet of life.

 

Isaacs, Jesse Rinehart of Yale, and the Harvard researchers explored whether they could expand upon nature’s handywork by substituting different codons or letters throughout the genome and then reintroducing entirely new letters to create amino acids not found in nature. This work marks the first time that the genetic code has been completely changed across an organism’s genome.

 

In the new study, the researchers working with E. coli swapped a codon and eliminated its natural stop sign that terminates protein production. The new genome enabled the bacteria to resist viral infection by limiting production of natural proteins used by viruses to infect cells. Isaacs — working with Marc Lajoie of Harvard, Alexis Rovner of Yale, and colleagues — then converted the “stop” codon into one that encodes new amino acids and inserted it into the genome in a plug-and-play fashion. 

 

The work now sets the stage to convert the recoded bacterium into a living foundry, capable of biomanufacturing new classes of  “exotic” proteins and polymers. These new molecules could lay the foundation for a new generation of materials, nanostructures, therapeutics, and drug delivery vehicles, Isaacs said.

 

“Since the genetic code is universal, it raises the prospect of recoding genomes of other organisms,” Isaacs said. “This has tremendous implications in the biotechnology industry and could open entirely new avenues of research and applications.”


Via Dr. Stefan Gruenwald
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odysseas spyroglou's curator insight, October 19, 2013 8:46 AM

The brave new world starts here. I hope we'll find our way to a less dystopian future.

Dmitry Alexeev's curator insight, October 20, 2013 4:18 AM

thats a new generation biological tool although there has been already attempts to encode non-standard amino acids - but never before on a full genome scale - intrestingle how soon wilkl this be available as a conventional instrument? this is a novel scientific tool - which will among others help us to study life

Leire Tapia's curator insight, October 21, 2013 4:08 PM

He elegido esta noticia porque la relaciono con la libertad de investigación. Es un derecho vinculado al ser humano y es un derecho exigible. Es también importante comunicar los resultados y no caer en el peligro de la censura. No hay que esconder lo que la ciencia descubre pero si es importante establecer límites relacionados con la protección de la salud y con la dignidad humana.

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Fossil Find Points To A Streamlined Human Lineage

Fossil Find Points To A Streamlined Human Lineage | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
A group of 1.8 million-year-old skulls suggests a single species can actually have a lot of variety.
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Autism and Gardening

Autism and Gardening | metal, wine, beer, yoga, cupcakes & golf | Scoop.it

Children with autism bloom in programs that couple inviting garden spaces with appropriately designed horticultural therapy activities.


Via Ron Wolford
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10 Tips To Increase Alexa Rank

10 Tips To Increase Alexa Rank | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
10 tips to increase your blog or website alexa rank they are proven and tested tips to increase Alexa Ranking

Via Level343
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Mac SEO Tips - Glenn Bearsky's comment, September 7, 2013 3:00 AM
Other than domain flippers - does anyone who's not in the Top 500 really CARE about Alexa and it's easy to manipulate rankings? They used to be an interesting tool to dabble in, but their backlink and keyword data was marginal at best. Now with free accounts crippled, and paid accounts RIDICULOUSLY expensive - they certainly aren't on my SEO radar anymore.
Ashlyn Maguire's curator insight, September 7, 2013 10:22 PM

"What's Alexa?" - "I don't know. Hey, what's Alexa?" ..."No clue, bro." ..."Alright, I'm looking it up right now.... Oh wow, ok. They call themselves 'The Web Information Company' - an Amazon company, and we definitely need to get on how our website and blog is ranking with them! SEO is the name of the game."

Ashlyn Maguire's curator insight, September 7, 2013 10:25 PM

"What's Alexa and why is it ranking us?" - "I don't know. Hey, what's Alexa?" ..."Uuuhhh..."

Do YOU KNOW what YOUR Alexa ranking is??

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Root-to-stalk: How to use all parts of the vegetable - San Francisco Chronicle

Root-to-stalk: How to use all parts of the vegetable - San Francisco Chronicle | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
San Francisco Chronicle
Root-to-stalk: How to use all parts of the vegetable
San Francisco Chronicle
I've been noticing an alarming trend in grocery stores.

Via Vivaldi
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Unearthing The Metal Underground At ProgPower USA

Unearthing The Metal Underground At ProgPower USA | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
Metal News: Unearthing The Metal Underground: The ProgPower USA Power Metal Edition
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Seed Saving: 6 Steps to Successfully Collecting Heirloom Flower Seeds

Seed Saving: 6 Steps to Successfully Collecting Heirloom Flower Seeds | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
Learn the basics of seed saving so that you can store, replant and share your favorite annual heirloom flowers!

Via Vivaldi
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ASHES OF ARES -- Track-By-Track (Part 2)

ASHES OF ARES is the new formation of Matt Barlow (ex-ICED EARTH), Van Williams (ex-NEVERMORE) and Freddie Vidales (ex-ICED EARTH). On September 6th, Nuclear...

Via Mandragore
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Beastie Boys' Mike D on His Wine Conversion and the Bottles That Got Away - Hungry Crowd | Food & Wine

Beastie Boys' Mike D on His Wine Conversion and the Bottles That Got Away - Hungry Crowd | Food & Wine | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
Food & Wine goes way beyond mere eating and drinking. We're on a mission to find the most exciting places, new experiences, emerging trends and sensations.
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Canary: The first smart home security device for everyone

Canary: The first smart home security device for everyone | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
Canary is a simple device packed with smart sensors that empowers you to keep your home safe and secure — controlled through your mobile device.
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Big fan of this security device.
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RentRoulette

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Fun game...but wait! This is real! If you ever looked for affordable rents in Connecticut you'd know it's no game.

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Brains Sweep Themselves Clean Of Toxins During Sleep

Brains Sweep Themselves Clean Of Toxins During Sleep | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
Mouse brains get washed with cerebrospinal fluid while they sleep. Humans may use the same process.
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Timo Tolkki's Avalon - Timo Tolkki's Avalon

Timo Tolkki's Avalon - Timo Tolkki's Avalon | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
Welcome to the Official Website of Timo Tolkki's Avalon. You can find all the actual info about the upcoming second part of the opera, featured guests and live shows.
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NFL Team Mandates Yoga

NFL Team Mandates Yoga | metal, wine, beer, yoga, cupcakes & golf | Scoop.it

Yoga and meditation round out coach Pete Carroll’s philosophy of wholistic care for his players. (This is exciting! Evene ballers are practicing yoga and meditation!

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LACUNA COIL Recording New Album

LACUNA COIL Recording New Album | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
Lacuna Coil, or The Cristina Scabbia Band as it might as well be at this point, are recording a new record. Please go listen to stuff like Comalies and get inspired?

Via Mandragore
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Rye Bother? An Inside-The-Barrel Look At American Whiskeys : NPR

Rye Bother? An Inside-The-Barrel Look At American Whiskeys : NPR | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
America is in the midst of a rye whiskey renaissance. Lovers of the spirit say it's spicier, edgier and less sweet than bourbons.

Via Frank Haddad
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Understanding the Chemical Fingerprint of Bourbon, Whiskey and Rye - Science News - redOrbit

Understanding the Chemical Fingerprint of Bourbon, Whiskey and Rye - Science News - redOrbit | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
As the art of distilling whiskey becomes increasingly popular, researchers from the University of California-Davis say they’re getting closer to understanding the chemical fingerprint of these brown spirits.

Via Frank Haddad
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Gary Hoey’s Rockin’ Holiday Show « Infinity Hall

Gary Hoey’s Rockin’ Holiday Show « Infinity Hall | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
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Our new favorite Christmas tradition---

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OH, SNAP

OH, SNAP | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
How to take better smartphone pics
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Valuable tricks and tips for that great Instagram shot

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If Ernest Hemingway Had Been A Cupcake Man, This Would Be The Cupcake For Him

If Ernest Hemingway Had Been A Cupcake Man, This Would Be The Cupcake For Him | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
We all know that Ernest Hemingway loved to drink.

Via Frank Haddad
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@themetalbaaka would love this cupcake! YUM!

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Beginner's Half Marathon Training Schedule

Beginner's Half Marathon Training Schedule | metal, wine, beer, yoga, cupcakes & golf | Scoop.it
If you have a few 5Ks and 10Ks under your belt, you're probably thinking about running your first half marathon. Doubling your racing distance means building endurance by increasing your weekly mileage.
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