Invasive melanoma rates are 17 times higher in men and 9 times higher in women than they were 60 years ago, according to a new analysis of Connecticut Tumor Registry data from 1950 to 2007. The registry included nearly 20,000 people with melanomas that had spread, as well as more than 3,600 who died from melanoma. Incidence rates rose from about 2 to 33 per 100,000 for men, and from more than 2 to 25 per 100,000 for women. In addition, mortality rates more than tripled in men (from 1.6 to about 5.0 per 100,000) and doubled in women (from 1.3 to 2.6 per 100,000). Calling U.S. melanoma rates an epidemic, the researchers urge targeting high-risk populations with a national prevention and early-detection program. In Germany, a screening program reduced melanoma deaths by 40%.