A new phase I clinical trial is underway to see if an experimental melanoma treatment works as well in people as it does in mice. The treatment entails injecting tumors with PV-10. A previous study in mice showed that just one PV-10 injection was enough to shrink melanomas. In addition, very early trials suggested that PV-10 boosts the immune system and the mouse study suggested that this treatment has fewer side effects than current immunotherapies. The new trial will assess whether PV-10 shrinks melanomas and keeps them from spreading in people, as well as whether PV-10 actually boosts the immune system. This trial is currently accepting participants.