Immune system cells that dive into tumors can make melanomas shrink and even disappear altogether. But these cells, called tumor-infiltrating lymphocytes, must be customized to target the specific proteins that are mutated in each melanoma — and identifying these mutated proteins is time-consuming. Now, there's a much faster way to screen melanomas for specific mutated proteins, report researchers in a Nature Medicine study. Rather than analyzing all of the DNA (genome), the new method looks only at the parts that code for proteins, which account for just 1% the genome. This method could also be used to quickly screen the mutated proteins in other kinds of tumors.