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Sentinel-Node Biopsy Improved DFS, Staging in Melanoma

Sentinel-Node Biopsy Improved DFS, Staging in Melanoma | Melanoma Dispatch | Scoop.it

Sentinel lymph node biopsy after wide excision improved DFS compared with wide excision alone among patients with intermediate and thick melanomas, according to final results of the MSLT-1 trial presented at the HemOnc Today Melanoma and Cutaneous Malignancies meeting in New York.


“ 'We found that performing sentinel lymph node biopsy is very accurate and improves staging in order to determine whether additional treatments are needed, such as additional surgery or adjuvant systemic therapy,' Robert H.I. Andtbacka, MD, CM, FACS, FRCSC, associate professor of surgery at Huntsman Cancer Institute at the University of Utah, said during a presentation. 'It also forms a basis for us to perform all the subsequent studies that we do in melanoma to make sure patients we have for our clinical trials are well balanced.' "


Editor's note: DFS stands for disease-free survival.

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Healio  |  Apr 15, 2014

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Thinner Melanomas May Warrant Sentinel Lymph Node Biopsies, Too

New research suggests that more people with melanomas should get sentinel lymph node (SLN) biopsies. Current guidelines recommend these biopsies when melanomas are more than 1 millimeter (mm) thick. However, the researchers identified 1,250 people who had melanomas thinner than 1 mm, and who had undergone SLN biopsies, and found that cancer cells had spread to the lymph nodes in more than 6% of those with melanomas between 0.75 and 1.00 mm thick. Based on this finding, the researchers call for dropping the thickness threshold for SLN biopsies to 0.75 mm.

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Journal of Clinical Oncology│Nov 4, 2013

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Lymph Nodes Should Be Biopsied for More Melanomas

Lymph Nodes Should Be Biopsied for More Melanomas | Melanoma Dispatch | Scoop.it

While standard for melanomas more than 1 millimeter (mm) thick, sentinel lymph node (SNL) biopsies are controversial for those that are thinner. But the latest research on 1,250 people with melanomas 1 mm or less suggests that the cutoff for SNL biopsies should be dropped to 0.75 mm. Moreover, tumor ulceration increases the urgency of SNL biopsies, doubling the risk that melanoma cells will spread to sentinel nodes (about 15% vs 6% for ulcerated and nonulcerated tumors, respectively). Positive SNLs guide doctors to treat melanoma more intensely, while negative SNLs spare people from anxiety, as well as from unnecessary follow-up care.

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HemOnc Today│Dec 16, 2013

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Thinner — Not Numerous — Skin Melanomas Linked to Survival

Thinner — Not Numerous — Skin Melanomas Linked to Survival | Melanoma Dispatch | Scoop.it

People who get one skin melanoma are more likely to get another, and recent research had suggested that those who do get another melanoma are more likely to survive than those who don't. But a new study in JAMA Dermatology shows that this counterintuitive finding is wrong. The researchers found that survival depends on the thickness rather than on the number of skin melanomas. This work was part of the Genes, Environment, and Melanoma Study, which is investigating the links between sun exposure, genetics and melanoma risk in 3,700 people from Australia, Canada, Italy and the US.

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Medical Xpress│Jun 24, 2013

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