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ASCO: OK to Stop Statins in Terminal Illness

ASCO: OK to Stop Statins in Terminal Illness | Melanoma Dispatch | Scoop.it

"Stopping statins for terminal patients doesn't hasten death and may improve their quality of life, a trial showed.


"The 60-day mortality rate didn't differ significantly after discontinuation of long-standing statin therapy compared with staying on it (23.8% versus 20.3%, P=0.60), Amy Abernethy, MD, PhD, of Duke University Medical Center, and colleagues found."

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MedPage Today  |  May 30, 2014

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Cancer Commons's curator insight, June 2, 2014 3:56 PM

MedPage Today  |  May 30, 2014

Cancer Commons's curator insight, June 2, 2014 3:56 PM

MedPage Today  |  May 30, 2014

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Combination Statin and Kinase Treatments Promising in Cultured Melanoma Cells

A new drug combination could treat melanomas that resist therapy with a single drug, suggests research that appeared in Cancer Discovery on melanoma cells grown in the laboratory. The researchers tested melanoma cells that had BRAF mutations and resisted treatment with the BRAF inhibitor vemurafenib, and that had NRAS mutations, which resist many treatments. The most effective combination treatment was statins, which are commonly used to treat high cholesterol, but can also kill melanoma cells, and drugs that inhibit proteins called cyclin-dependent kinases, which are involved in cell division.

 

Primary source: http://cancerdiscovery.aacrjournals.org/content/3/1/52.abstract?sid=6d6d2d16-9fee-4558-b7e4-72874b041917

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Dermatology Times | Dec 19, 2012

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