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A Wide Variety of Cancers Imaged and Treated with New Tumor-Targeting Agent

"Scientists at the University of Wisconsin Carbone Cancer Center (UWCCC) report that a new class of tumor-targeting agents can seek out and find dozens of solid tumors, even illuminating brain cancer stem cells that resist current treatments.


"What's more, years of animal studies and early human clinical trials show that this tumor-targeting, alkylphosphocholine (APC) molecule can deliver two types of 'payloads' directly to cancer cells: a radioactive or fluorescent imaging label, or a radioactive medicine that binds and kills cancer cells.


"The results are reported in today's issue of the journal Science Translational Medicine, and featured in the journal's cover illustration and podcast."


Editor's note: This story discusses a new method to make cancer cells visible to oncologists, and to deliver drugs directly to cells. The method uses a molecule called APC, which makes a beeline for cancer cells and can deliver imaging labels or radiotherapy treatments.

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Medical News Today  |  Jun 13, 2014

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Medical News Today  |  Jun 13, 2014

Cancer Commons's curator insight, June 13, 2:29 PM

Medical News Today  |  Jun 13, 2014

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Targeted Radiation Could Help Find and Treat Melanomas

Targeted Radiation Could Help Find and Treat Melanomas | Melanoma Dispatch | Scoop.it

A pair of new studies shows the promise of using radioactive drugs to reveal and shrink melanomas. The drugs are based on benzamide, a small molecule that binds the dark pigment in melanomas (melanin). In the first study, a phase III clinical trial showed that a new melanin-binding radioactive tag is not as good as the current radioactive tag for staging melanomas. While the current tag is not specific to melanomas, the new tag fell short because melanoma produces less melanin as it progresses. However, the researchers point out that the new tag may still help diagnose melanomas that have spread. The second study included 26 people with melanomas that had spread, and nine received a radioactive melanin-binding treatment at a range of doses. Encouragingly, three of the five with doses higher than the range average survived more than two years.

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The Journal of Nuclear Medicine  |  Jan 1, 2014

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Radiotherapy Relieves Pain from Bone Tumors in Elderly Patients

Radiotherapy Relieves Pain from Bone Tumors in Elderly Patients | Melanoma Dispatch | Scoop.it

Cancer that spreads to the bones can cause debilitating pain that is often treated with morphine, an opioid drug that has its own downsides, from grogginess to nausea to constipation. But radiotherapy could lessen the need for morphine among elderly individuals with bone tumors, researchers reported at the 2013 forum of the European Society for Radiotherapy and Oncology. The researchers gave radiotherapy to patients aged 75 years and up whose cancer (primarily breast, lung, or prostate) had spread to their bones. Regular follow-up surveys revealed that a single radiotherapy treatment helped relieve pain. The surveys also showed that despite their physical impairments, the elderly patients treated with radiotherapy were as satisfied with their quality of life as younger patients.

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Medical News Today│Apr 24, 2013

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Medical News Today│Apr 24, 2013

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Medical News Today│Apr 24, 2013

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New Treatment Proposed to Prevent Devastating Intestinal Inflammation in Cancer Patients

New Treatment Proposed to Prevent Devastating Intestinal Inflammation in Cancer Patients | Melanoma Dispatch | Scoop.it

"Experimental work pointing to a therapy for alleviating mucositis -- a common, severe side effect of chemotherapy and irradiation of cancer patients or patients prepared for bone marrow transplantation – has been achieved by an international team of researchers. Mucositis is a strong inflammatory reaction of the mucosal lining of the digestive system, particularly the gut. Mucositis is often a major reason for premature suspension of anti-cancer therapy. As of today, there has been no effective means of preventing mucositis or its treatment."

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ScienceDaily  |  Feb 18, 2014 

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ScienceDaily  |  Feb 18, 2014 

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ScienceDaily  |  Feb 18, 2014 

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New Software Quickly Maps Tumors for Radiotherapy

New Software Quickly Maps Tumors for Radiotherapy | Melanoma Dispatch | Scoop.it

To help protect healthy tissues from the radioactive drugs that target tumors, oncologists laboriously map the tumors by hand from sections of three-dimensional (3-D) images. But now researchers have developed a faster way. Based on computed tomography (CT) imaging data from a patient, 3-D graphic design software creates a model of the tumor in just an hour or two. When combined with a test that simulates the fate of therapeutic radioactivity in the body, the tumor model also lets oncologists personalize the radiotherapy dose. A study of several patients showed that this fast, new method maps organs and radiotherapy doses as accurately as conventional methods. The new software is expected to be used in a clinical trial of a tumor-targeted radiotherapy; a commercial version is scheduled for release to other cancer centers next year.

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Medical Xpress│June 11, 2013

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Medical Xpress│June 11, 2013

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Medical Xpress│Jun 11, 2013

Cancer Commons's curator insight, June 12, 2013 1:05 PM

Medical Xpress│June 11, 2013