Blood Pressure Drug Boosts Chemotherapy Delivery in Mice | Melanoma Dispatch |

One reason chemotherapies fail is that blood vessels are collapsed in the middle of tumors, blocking the delivery of anticancer drugs. Now, new research suggests that a blood pressure drug called losartan may facilitate chemotherapy throughout tumors. Losartan decompresses tumor blood vessels, increasing blood flow and chemotherapy drug delivery in mouse models of breast and pancreatic cancer. To see if these findings will also hold for people, a phase II clinical trial of pancreatic cancer patients is underway. This trial is currently accepting new participants.