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OncoSec Medical Presents Positive Phase 2 Interim Data Evaluating ImmunoPulse in Melanoma

"OncoSec Medical Inc. (OTCQB: ONCS), a company developing its ImmunoPulse DNA-based intratumoral cancer immunotherapy, announced interim data from its Phase 2 melanoma study at the American Society of Clinical Oncology’s (ASCO) 50th Annual Meeting in Chicago. The abstract, titled “Systemic anti-tumor effect and clinical response in a Phase 2 trial of intratumoral electroporation of plasmid interleukin-12 in patients with advanced melanoma” (ASCO Abstract #9025), was presented by Adil Daud, M.D., OncoSec’s Chief Clinical Strategist and Principal Investigator of the Phase 2 melanoma study, and selected for discussion during a poster highlights session for melanoma/skin cancers led by Axel Hauschild, M.D., Ph.D."


Editor's note: This article describes a promising immunotherapy treatment that boosts a patient's own immune system to fight melanoma. 

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Yahoo! Finance  |  Jun 2, 2014

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New Immunotherapy May Turn IL-12 On and Off in Melanomas

New Immunotherapy May Turn IL-12 On and Off in Melanomas | Melanoma Dispatch | Scoop.it

Doctors may someday be able to adjust interleukin-12 (IL-12) levels in melanomas at will, according to results of an ongoing clinical trial presented at Melanoma Bridge 2013 Conference in Naples, Italy. IL-12 is an immune system protein that can shrink melanomas, but also has nasty side effects. The experimental immunotherapy entails injecting tumors with a virus that does not cause diseas, and that has been engineered to produce the IL-12 when people take a drug called veledimex. In the phase I/II trial of 21 people with melanomas that had been injected with this engineered virus, IL-12 production turned on when they took veledimex and turned off when they stopped. Depending on the dose, veledimex increased IL-12 production by 1,000 to 100,000 times.

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ZIOPHARM Oncology, Inc. │Dec 7, 2013

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Zapping Melanomas Stimulates Uptake of Immune System Booster

Zapping Melanomas Stimulates Uptake of Immune System Booster | Melanoma Dispatch | Scoop.it

Early results of a phase II clinical trial are encouraging for a new immunotherapy against melanomas. The first step is injecting the melanoma with engineered DNA that contains the gene for interleuken-12, a protein that stimulates the immune system. The next step, called electroporation, is to shock the tumor with 1,300 volts. This opens pores the melanoma cells, letting them take up the engineered DNA. The tumor then produces the immune system booster interleuken-12. In one arm of this multi-center trial, tumors have shrunk in eight of the nine people treated. And tumors often also shrank in parts of the body that weren't directly treated. This trial is accepting new participants.

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KGO-TV│Jul 17, 2013

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Virus Engineered to Make Interleukin Shrinks Melanomas in Early Trial

Virus Engineered to Make Interleukin Shrinks Melanomas in Early Trial | Melanoma Dispatch | Scoop.it

An experimental treatment shrinks melanomas by pumping them full of interleukin-12, a protein that boosts the body's immune response against cancer. Developed by ZIOPHARM Oncology, the treatment has two steps: 1) injecting tumors with Ad-RTS-IL-12, a virus that has been engineered to make interleukin, and 2) controlling how much interleukin is made with a drug called INXN‑1001. A phase I clinical trial showed that this treatment increases white blood cells near melanomas and makes tumors flatter and smaller. These findings were presented at the American Society for Clinical Oncology's 2013 meeting. A phase II trial of this immunotherapy is underway in up to 15 patients.

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Global Newswire│Jun 1, 2013

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IL-12 Therapy May Shrink Melanomas Not Directly Treated

IL-12 Therapy May Shrink Melanomas Not Directly Treated | Melanoma Dispatch | Scoop.it

An experimental immunotherapy that delivers interleukin-12 (IL-12) directly into a melanoma tumor may also shrink tumors elsewhere in the body. Called ImmunoPulse, the treatment entails injecting a tumor with interleukin-12 DNA and delivering electric shocks to make the tumor cells absorb this DNA. These cells then produce IL-12, boosting the immune response against the tumor. In an ongoing phase II trial of 21 people with melanomas that were treated with ImmunoPulse, tumors shrank in 8 of them (38%) and disappeared for at least 6months in 2 more of them. Moreover, untreated tumors also shrank in about 60%. The possibility of body-wide effects is encouraging because, in contrast to systemic IL-12 therapy, ImmunoPulse treatments have yet to cause serious side effects.

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OncoSec Medical Inc. │ Dec 16, 2013

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Immunotherapy Gene Delivered Via Electrical Shock Shrinks Melanomas

Immunotherapy Gene Delivered Via Electrical Shock Shrinks Melanomas | Melanoma Dispatch | Scoop.it

A new immunotherapy shrank most of the melanomas treated in a clinical trial, researchers reported at the 2013 World Cutaneous Malignancies Congress. The results are from a phase II trial that included 13 people and 37 treated tumors. The treatment entailed injecting tumors with DNA containing the gene for an immune system booster called interleukin-12, and then giving the tumor an electrical shock to make it take up the engineered DNA. By 90 days after treatment, 80% of the melanomas had shrunk and nearly half had disappeared completely.

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The ASCO Post│Jul 29, 2013

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DNA-based Immunotherapy for Melanoma Advances in Clinical Trials

DNA-based Immunotherapy for Melanoma Advances in Clinical Trials | Melanoma Dispatch | Scoop.it

A promising new immunotherapy for melanoma is about to start a phase II clinical trial. Called ImmunoPulse, the two-step treatment entails injecting tumors with DNA that encodes an immune system protein called interleukin-12, and then delivering electric shocks to make the tumor cells absorb the DNA. These cells then produce interleukin-12, which boosts the immune response to the tumor. In an early trial of the new treatment on 13 people with melanoma, tumors shrank in all of them and hadn't grown six months later in about half of them. The new trial will test how well this new immunotherapy controls the injected tumors as well as tumors elsewhere in the body, and results are expected in 6 months to a year, says ImmunoPulse developer OncoSec Medical Inc.


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Daily Finance│June 18, 2013

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