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Hypertension Related to New Cancer Therapies - A New Syndrome Emerges

"New cancer therapies, particularly agents that block vascular endothelial growth factor (VEGF) signaling, have improved the outlook for patients with some cancers and are now used as a first line therapy for some tumors. However, almost 100% of patients who take VEGF inhibitors (VEGFIs) develop high blood pressure, and a subset develops severe hypertension. The mechanisms underlying VEGF inhibitor-induced hypertension need to be better understood and there is a need for clear guidelines and improved management, say investigators in a review article published in the Canadian Journal of Cardiology."

Cancer Commons's insight:

Medical News Today  |  May 7, 2014

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Cancer Commons's curator insight, May 7, 2014 6:17 PM

Medical News Today  |  May 7, 2014

Cancer Commons's curator insight, May 7, 2014 6:17 PM

Medical News Today  |  May 7, 2014

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Marker May Predict Response to Ipilimumab in Advanced Melanoma

Marker May Predict Response to Ipilimumab in Advanced Melanoma | Melanoma Dispatch | Scoop.it

"Among patients with advanced melanoma, presence of higher levels of the protein vascular endothelial growth factor (VEGF) in blood was associated with poor response to treatment with the immunotherapy ipilimumab, according to a study published inCancer Immunology Research, a journal of the American Association for Cancer Research.


"The study suggests combining immunotherapy with VEGF inhibitors, also known as angiogenesis inhibitors, may be a potential option for these patients."

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Medical Xpress  |  Feb 4, 2014

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