Nature Study Points to New Strategy for Treating Acute Myeloid Leukemia HealthCanal.com He is a co-author of the collaborative multicenter study, together with Lan Wang, Ph.D., assistant professor of biochemistry and molecular biology at the Miller...
Hematology Oncology | The addition of entinostat to exemestane improved clinical outcomes in postmenopausal women with ER-positive advanced breast cancer that progressed on nonsteroidal aromatase inhibitors, according to results of a phase 2 study.
This new report provides a comprehensive analysis of the 10 major POC market segments, including their dynamics, size, growth, regulatory requirements, technological trends, competitive landscape, and emerging opportunities for instrument and consumable suppliers. This report will help diagnostic product suppliers develop effective business, R&D and marketing strategies.
The growing economic pressures on hospitals, coupled with advances in diagnostic technologies, intensifying competition among suppliers and physicians, and changing consumer demands are shifting diagnostic testing from hospitals and commercial laboratories closer to the patient.
Market Segmentation Analysis
- Review of the 10 major POC market segments, including their dynamics, trends, structure, size, growth and major suppliers.
- Five-year test volume and reagent sales forecasts for over 300 chemistry, immunodiagnostic, microbiology, hematology and coagulation procedures by market segment:
- Review of leading chemistry, immunoassay, hematology and coagulation analyzers, both currently marketed and those in development, including their operating characteristics,features and selling prices.
- Emerging technologies and their applications for POC testing.
- Comprehensive listings of companies developing or marketing POC diagnostic technologies and products, by test.
- Assessments of major suppliers and emerging market entrants, including their sales, product portfolios, marketing tactics, joint ventures, and new products in R&D.
- Specific opportunities for new POC instruments and reagent systems with potentially significant market appeal during the next five years.
- Design criteria for POC testing products.
- Alternative business expansion strategies.
- Potential market entry barriers and risks.
This report is based on a combination of primary and secondary sources of information, including review of recent technical and business publications, manufacturer product literature, industry analyst reports, and Venture Planning Group’s proprietary data files.
ABC Science Online Termites create their own antibiotics ABC Science Online First, termites possess an innate immunity, due to their biochemistry, which wards off bodily intruders, such as bacteria and pesticides.
Federal And State Governments Lend Support To Cord Blood Banking PR Newswire (press release) The most recent development happened on May 16th when the New York State Senate introduced a bill to create a public umbilical cord blood banking program...
New test improved prostate cancer risk assessment Healio A new genomic screening test significantly improved the ability to predict disease aggressiveness in patients at risk for prostate cancer, according to results presented at the American...
A decade ago, Francis Collin's research lab at NIH helped discover the cause of the Hutchinson-Gilford progeria syndrome: a mutation in the lamin-A gene. Just a single letter substitution in the genetic code (C to T) creates a toxic version of the protein. The abnormal protein is missing a segment, and is no longer digestible by an enzyme called ZMPSTE24—essentially a molecular scissors. Without that final snip, the lamin-A protein causes molecular havoc.More recently, children who are completely missing the ZMPSTE24 enzyme have been identified, and they have an even more severe form of progeria called “restrictive dermopathy”. Many questions remain but now we are able to get a close up of ZMPSTE24 and understand how, and where, it normally modifies lamin-A.
Using x-ray crystallography, a team based at the UK’s University of Oxford figured out the enzyme’s molecular structure [2, 3]. A cross section of the 3D structure (seen above) reveals a cavernous inner chamber where the authors believe the final snip of lamin-A takes place. It also shows us how mutations in ZMPSTE24, which inhibit lamin-A processing, can also lead to these rare aging disorders.
Knowing ZMPSTE24’s structure will help us better understand its clipping functions. It could also shed light on how this enzyme works in the normal aging processes—as well as in the accelerated aging of progeria. Ultimately, we hope it will also inform drug development for this devastating disease.
 Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.
 The structural basis of ZMPSTE24-dependent laminopathies. Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP. Science. 2013 Mar 29;339(6127):1604-7.
 Biochemistry. A protease for the ages. Michaelis S, Hrycyna CA. Science. 2013 Mar 9;339(6127):1529-30.
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