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Promising results from the world's first oncolytic-virus cancer therapy trial

Promising results from the world's first oncolytic-virus cancer therapy trial | 21st Century Medical English Teaching and Technology Resources | Scoop.it

Researchers from the Ottawa Hospital Research Institute (OHRI), the University of Ottawa (uOttawa), Jennerex Inc. and several other institutions today reported promising results of a world-first cancer therapy trial in the renowned journal Nature.

 

The trial is the first to show that an intravenously-delivered viral therapy can consistently infect and spread within tumours without harming normal tissues in humans. It is also the first to show tumor-selective expression of a foreign gene after intravenous delivery.

 

The trial involved 23 patients (including seven at The Ottawa Hospital), all with advanced cancers that had spread to multiple organs and failed to respond to standard treatments. The patients received a single intravenous infusion of a virus called JX-594, at one of five dose levels, and biopsies were obtained eight to 10 days later. Seven of eight patients (87 per cent) in the two highest dose groups had evidence of viral replication in their tumor, but not in normal tissues. All of these patients also showed tumor-selective expression of a foreign gene that was engineered into the virus to help with detection. The virus was well tolerated at all dose levels, with the most common side effect being mild to moderate flu-like symptoms that lasted less than one day.

 

"We are very excited because this is the first time in medical history that a viral therapy has been shown to consistently and selectively replicate in cancer tissue after intravenous infusion in humans," said Dr. John Bell, a Senior Scientist at OHRI, Professor of Medicine at uOttawa and senior co-author on the publication. "Intravenous delivery is crucial for cancer 

 IMAGE: Dr. John Bell, a cancer research scientist at the Ottawa Hospital Research Institute and the University of Ottawa, is a leader in developing oncolytic viruses for the treatment of cancer.

Click here for more information.

 

treatment because it allows us to target tumors throughout the body as opposed to just those that we can directly inject. The study is also important because it shows that we can use this approach to selectively express foreign genes in tumours, opening the door to a whole new suite of targeted cancer therapies."

 

Dr. Bell and his team have been investigating cancer-fighting (oncolytic) viruses at OHRI for more than 10 years. JX-594 was developed in partnership with Jennerex Inc., a biotherpeutics company co-founded by Dr. Bell in Ottawa and Dr. David Kirn in San Francisco. JX-594 is derived from a strain of vaccinia virus that has been used extensively as a live vaccine against smallpox. It has a natural ability to replicate preferentially in cancer cells, but it has also been genetically engineered to enhance its anti-cancer properties.

 

"Oncolytic viruses are unique because they can attack tumours in multiple ways, they have very mild side effects compared to other treatments, and they can be easily customized for different kinds of cancer," said Dr. Bell. "We're still in the early stages of testing these viruses in patients, but I believe that someday, viruses and other biological therapies could truly transform our approach for treating cancer."

 

Although the current trial was designed primarily to assess safety and delivery of JX-594, anti-tumor activity was also evaluated. Six of eight patients (75%) in the two highest dose groups experienced a shrinking or stabilization of their tumor, while those in lower dose groups were less likely to experience this effect.

 

"These results are promising, especially for such an early-stage trial, with only one dose of therapy," said Dr. Bell. "But of course, we will need to do more trials to know if this virus can truly make a difference for patients. We are working hard to get these trials started, and at the same time, we are also working in the laboratory to advance our understanding of these viruses and figure out how best to use them."

 

 


Via Dr. Stefan Gruenwald
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Could Ebola Spread to the United States or Europe? | Live Science

Could Ebola Spread to the United States or Europe? | Live Science | 21st Century Medical English Teaching and Technology Resources | Scoop.it
The current outbreak of Ebola in West Africa is now the largest in history, but how likely is it to spread to the United States or other countries around the world? It's theoretically possible that people with Ebola could travel to other countries on planes, and infect others outside the region. The medical group Doctors Without Borders has said the epidemic is "out of control" in the region, and that they do not have the resources to care for the growing number of people who are sick. Could Ebola come to the U.S.?
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"One reason why the Ebola virus's spread is possible in theory is that it can take up to 21 days for an infected person to show symptoms.


That's ample time for someone with Ebola to travel a long distance by plane and arrive in the United States or Europe, said Derek Gatherer, a researcher at Lancaster University in the United Kingdom who studies virus genetics and evolution. [5 Things You Should Know About Ebola]"


How many Ebola deaths are acceptable in the United States or Europe?  

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Doctors Without Borders: Ebola 'out of control' | AP

Doctors Without Borders: Ebola 'out of control' | AP | 21st Century Medical English Teaching and Technology Resources | Scoop.it
DAKAR, Senegal (AP) — The Ebola outbreak ravaging West Africa is "totally out of control," according to a senior official for Doctors Without Borders, who says the medical group is stretched to the limit in responding.
Rob Hatfield, M.Ed.'s insight:

 "A senior official for Doctors Without Borders said this outbreak is particularly challenging because it began in an area where people are very mobile and has spread to even more densely populated areas, like the capitals of Guinea and Liberia.... The disease typically strikes sparsely populated areas in central or eastern Africa, where it spreads less easily, he said.By contrast, the epicenter of this outbreak is near a major regional transport hub, the Guinean city of Gueckedou".

 

This is very serious and needs global assistance and attention.

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Statement on the Long-Term Scientific Vision for the BRAIN Initiative | National Institutes of Health (NIH)

Statement on the Long-Term Scientific Vision for the BRAIN Initiative | National Institutes of Health (NIH) | 21st Century Medical English Teaching and Technology Resources | Scoop.it

Today, the BRAIN Working Group presented its final report to the ACD, which accepted its recommendations. I am excited about the bold vision laid out for BRAIN by this distinguished group of scientists, and have accepted the recommendations in their entirety.

 

Not only will BRAIN revolutionize neuroscience, it will transform our efforts to help the millions of people suffering from Alzheimer’s disease, autism, epilepsy, schizophrenia, traumatic brain injury, and many other neurological disorders. 

Rob Hatfield, M.Ed.'s insight:

There are many BRAIN Initiative medical teaching and learning resources provided for your 21st Century learning environment.

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Ten Study Methods That Work | FOM

Ten Study Methods That Work | FOM | 21st Century Medical English Teaching and Technology Resources | Scoop.it

Studying effectively is not a matter of chance. Educators and psychologists have researched study methods for years. Some of the best studies come from the top universities: Stanford, Indiana, and Chicago where precise experiments with student groups have shed light on the most effective study methods.


Students who follow these methods learn more easily, retain material for longer periods of time, and save themselves hours of study time. The ten study methods researchers have found that work are:

Read more at: http://forum.facmedicine.com//threads/ten-study-methods-that-work.17657/

Rob Hatfield, M.Ed.'s insight:

The methods of study listed here are used in all teaching and learning environment throughout the world.

 

Be sure to include Evernote and use one of the three note taking methods; Outline, Cornell or Mind Mapping.

 

I also promote the use of flash cards and use www.studystack.com

 


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The Best 15 Free Android Medical apps for Doctors and Medical Students | FOM

The Best 15 Free Android Medical apps for Doctors and Medical Students | FOM | 21st Century Medical English Teaching and Technology Resources | Scoop.it
1. Medscape


One of the most anticipated apps to hit Android, Health care professionals had been waiting eagerly for this comprehensive medical...
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These are good medical education resources to add to your mobile device.

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InnerBody.com | Your Interactive Guide to Human Anatomy

InnerBody.com | Your Interactive Guide to Human Anatomy | 21st Century Medical English Teaching and Technology Resources | Scoop.it
Online since 1997, InnerBody is your go-to resource for accurate and easy-to-use information about human anatomy.
Rob Hatfield, M.Ed.'s insight:

Excellent supplemental Medical English resources to use in your 21st century teaching and learning environment.

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CDC: 5 ways diseases in other countries can kill you

CDC: 5 ways diseases in other countries can kill you | 21st Century Medical English Teaching and Technology Resources | Scoop.it
The U.S. joins other nations, organizations to launch the Global Health Security Agenda, an effort to work toward a world free of infectious disease.

 

The world is smaller and people are more mobile than at any time in history. This makes it easier than ever for what's happening anywhere on the globe to harm Americans' health.  

 

Listed are five ways diseases in other countries pose a threat.

Rob Hatfield, M.Ed.'s insight:

This is a good review for those who travel abroad to check out what is happening in the region prior to travel.

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Tropical Medicine Mystery: Something is Killing Young Men in Central America | Speaking of Medicine

Tropical Medicine Mystery: Something is Killing Young Men in Central America  | Speaking of Medicine | 21st Century Medical English Teaching and Technology Resources | Scoop.it
Over the last decade drug trafficking and violence have taken the lives of thousands of people, most of them young men, in Guatemala, Honduras, and elsewhere in Central America.
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...More than just a travel warning...

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EKG Self Study Guide | MEDICAL PPT|Collection of Free Online Medical Powerpoint Presentations

EKG Self Study Guide | MEDICAL PPT|Collection of Free Online Medical Powerpoint Presentations | 21st Century Medical English Teaching and Technology Resources | Scoop.it
MEDICAL PPT:MEDICAL POWERPOINT PRESENTATIONS FOR MEDICAL STUDENTS AND POST GRADUATES
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Excellent teaching and learning resources.

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Google Unveils Smart Contact Lens That Lets Diabetics Measure Their Glucose Levels | TechCrunch

Google Unveils Smart Contact Lens That Lets Diabetics Measure Their Glucose Levels | TechCrunch | 21st Century Medical English Teaching and Technology Resources | Scoop.it

This isn’t Google Glass in a contact lens, but it may just be Google’s first step in this direction. The company’s Google X lab just teased a smart contact lens on its blog that is meant to help diabetics measure their glucose levels.

 

The company says it is currently testing prototypes of this contact lens that use a tiny wireless chip and a miniaturized glucose sensor. These chips are embedded in between two soft layers of lens material.

Rob Hatfield, M.Ed.'s insight:

What a cool and painless technology development for diabetics.

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EdTech 10: Favorite Blog Posts of 2013 | Getting Smart

EdTech 10: Favorite Blog Posts of 2013 | Getting Smart | 21st Century Medical English Teaching and Technology Resources | Scoop.it
2013 had no shortage of great blog content. We were thrilled, humbled and amazed by the content shared and thoughtful feedback from readers. Below our team compiled a list of the top 10 blogs we enjoyed this year.
Rob Hatfield, M.Ed.'s insight:

Great list ! The list is worth reviewing as many topics are my favorites too and worth sharing.

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Neuroscience For Kids

Neuroscience For Kids | 21st Century Medical English Teaching and Technology Resources | Scoop.it
Intended for elementary and secondary school students and teachers who are interested in learning about the nervous system and brain with hands on activities, experiments and information.
Rob Hatfield, M.Ed.'s insight:

Excellent teaching and learning resources to use in your learning environment.

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The Cell: An Image Library | Free High Quality, World Class Medical Education Resources.

The Cell: An Image Library | Free High Quality, World Class Medical Education Resources. | 21st Century Medical English Teaching and Technology Resources | Scoop.it

The Cell: An Image Library™ is a freely accessible, easy-to-search, public repository of reviewed and annotated images, videos, and animations of cells from a variety of organisms, showcasing cell architecture, intracellular functionalities, and both normal and abnormal processes.


The purpose of this database is to advance research, education, and training, with the ultimate goal of improving human health.

Rob Hatfield, M.Ed.'s insight:

The Cell: An Image Library provides free high quality, world class medical education resources.

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'Drastic action is needed' now to stop Ebola epidemic WHO | CNN

'Drastic action is needed' now to stop Ebola epidemic WHO | CNN | 21st Century Medical English Teaching and Technology Resources | Scoop.it
The World Health Organization says "drastic action is needed" to stop the Ebola virus outbreak.

 

(CNN) -- The World Health Organization says "drastic action is needed" to stop the deadly Ebola virus outbreak in West Africa. It has sent teams of experts to help locals deal with the epidemic and WHO plans to meet next week to discuss how to contain it.

 

Relief workers on the ground said the epidemic has hit unprecedented proportions.

Rob Hatfield, M.Ed.'s insight:

This is becoming very dangerous requires immediate international attention and support for containment. NOW! 

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Pedagogy in Health Promotion: The Scholarship of Teaching and Learning

Pedagogy in Health Promotion: The Scholarship of Teaching and Learning | 21st Century Medical English Teaching and Technology Resources | Scoop.it
SOPHE is excited to announce a call for Editor-in-Chief and Editorial Board Members for its newest peer-reviewed journal, Pedagogy in Health Promotion: The Scholarship of Teaching and Learning. The quarterly journal’s mission is to advance pedagogy, student/faculty relationships and academic administrative issues relevant to faculty, students, and academic administrators, as well as instructors or trainers who provide continuing education in public health, community health, school health, health promotion, and related areas. Published by Sage Publications, the first issue will be disseminated in Spring 2015.
Rob Hatfield, M.Ed.'s insight:

Announcement of SOPHE teaching and learning scholarship.

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A High-Tech Prescription for Training Doctors Campus Technology

A High-Tech Prescription for Training Doctors  Campus Technology | 21st Century Medical English Teaching and Technology Resources | Scoop.it

Tech-enabled programs aim to give med students more practical, hands-on experience.

Rob Hatfield, M.Ed.'s insight:

This is a good review of updated and modified, blended learning with competency-based assessment.

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IndexCat™: Search It, Read It, Download It

IndexCat™: Search It, Read It, Download It | 21st Century Medical English Teaching and Technology Resources | Scoop.it

Today, the NLM’s historical collections include millions of items that span the centuries in a wide variety of formats: books, journals, photographs, motion picture films, film strips, video tapes, audio recordings, pamphlets, ephemera, and portraits.


These collections stand among others that consist of more modern formats: born digital materials and rich databases such as IndexCat™, a searchable presentation of the unique and staggeringly useful research tool initiated by Billings, theIndex-Catalogue of the Library of the Surgeon-General’s Office. 

Rob Hatfield, M.Ed.'s insight:

U.S. National Library of Medicine is a world class medical teaching, learning and research data base for any medical resource library. Now made easier to access with Indexcat.

 

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16 THINGS YOU’LL ONLY UNDERSTAND IF YOU’RE A MEDICAL STUDENT

And now for something completely different...

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On the lighter side of medicine...

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Interactive Health Tutorials: MedlinePlus

Interactive Health Tutorials: MedlinePlus | 21st Century Medical English Teaching and Technology Resources | Scoop.it

MedlinePlus presents interactive health tutorials from the Patient Education Institute.

 

Learn about the symptoms, diagnosis and treatment for a variety of diseases and conditions. Also learn about surgeries, prevention and wellness.

 

Each tutorial includes animated graphics, audio and easy-to-read language.

Rob Hatfield, M.Ed.'s insight:

Excellent supplemental Medical English resources to use in your 21st century teaching and learning environment.

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These Are The Best And Worst Countries To Be Elderly

These Are The Best And Worst Countries To Be Elderly | 21st Century Medical English Teaching and Technology Resources | Scoop.it

The United States ranks eighth in the world for the wellbeing of the elderly, according to a new study that looks at the welfare of people aged over 65 in 91 different countries.


Sweden ranks first, followed by Norway and Germany. At the bottom of the list are Pakistan, Tanzania and Afghanistan.


The United States, which typically ranked near the bottom of developed nations on these sorts of human welfare indices, performs unusually well here.

Rob Hatfield, M.Ed.'s insight:

Interesting perspective with the largest growing segment in the world.

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World map of vaccine-preventable outbreaks

World map of vaccine-preventable outbreaks | 21st Century Medical English Teaching and Technology Resources | Scoop.it

There's a new world map of current vaccine-preventable outbreaks . AND, closer to home, a new PLOS Blogs post from Public Health Perspectives blogger Beth Skwarecki "H1N1 is Back, What You Need to Know.

Rob Hatfield, M.Ed.'s insight:

These are great teaching and learning resources for medical education.

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Almost Three Times the Risk of Carrying MRSA from Living Near a Mega-Farm | Wired Science

Almost Three Times the Risk of Carrying MRSA from Living Near a Mega-Farm | Wired Science | 21st Century Medical English Teaching and Technology Resources | Scoop.it

In the long fight over antibiotic use in agriculture, one of the most contentious points is whether the resistant bacteria that inevitably arise can move off the farm to affect humans.


Most of the illnesses that have been associated with farm antibiotic use — resistant foodborne illness, for example — occur so far from farms that opponents of antibiotic control find them easy to dismiss. So whenever a research team can link resistant bacteria found in humans with farms that are close to those humans, it is an important contribution to the debate.

Rob Hatfield, M.Ed.'s insight:

One of my key medical educators focuses is on MRSA. Hopefully, more with awareness and prevention, it will reduce occurrence issues.

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New Look Inside Cell Nucleus Could Improve Cancer Diagnostics | UANews

New Look Inside Cell Nucleus Could Improve Cancer Diagnostics | UANews | 21st Century Medical English Teaching and Technology Resources | Scoop.it

Researchers have sequenced the entire messenger RNA – the "genetic photocopies" – contained in the nucleus of a single cell, a long-anticipated step toward better cancer diagnostics and other medical applications.

Rob Hatfield, M.Ed.'s insight:

The future is looking brighter in the fight in Cancer and cancer related diagnostics.

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2013 Research Highlights - NIH Research Matters - National Institutes of Health (NIH)

2013 Research Highlights - NIH Research Matters - National Institutes of Health (NIH) | 21st Century Medical English Teaching and Technology Resources | Scoop.it

With NIH support, scientists across the country and the world conduct wide-ranging research to improve the health of the nation. Groundbreaking NIH-funded research often receives top scientific honors. In 2013, all 3 recipients of the Nobel Prize in Physiology or Medicine, and all 3 awardees of the Nobel Prize in Chemistry, received NIH funding at different times in their careers. Four NIH-funded scientists also won awards from the Lasker Foundation in 2013. Here's just a small sampling of the research accomplishments made by NIH-supported scientists in 2013:

Rob Hatfield, M.Ed.'s insight:

This is an excellent overview of 21st century research, teaching and learning for the year 2013.

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The Paradoxical Traits Of Resilient People

The Paradoxical Traits Of Resilient People | 21st Century Medical English Teaching and Technology Resources | Scoop.it

Journalist Hara Estroff Marano once wrote in a Psychology Today article "The Art of Resilience":

 

"Resilience may be an art, the ultimate art of living…

At the heart of resilience is a belief in oneself--yet also a belief in something larger than oneself. Resilient people do not let adversity define them. They find resilience by moving towards a goal beyond themselves, transcending pain and grief by perceiving bad times as a temporary state of affairs."

 

She argues that it is possible to strengthen your inner self and your belief in yourself, to define yourself as capable and competent. It's possible to fortify your psyche. It's possible to develop a sense of mastery.

Rob Hatfield, M.Ed.'s insight:

This article is a series of papers review aspects of Ethos, Pathos and Logos.

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