TRUE weight bearing & non-weight bearing 3D imaging for one or both feet.
I've known a system to 3D model feets in one shot, both bearing and bearing load, for at least 8 years. It was developed by the Spanish companies Metria and Delcam España within the frame of funded collaborative project.
It only made the 3D model of the outside, that's true. This is a great dedicated product, as an outcome of the digital RX world.
People losing sight in one eye cannot do binocular disparity processing. It means they cannot perceive the sense of distance from the binocular disparity, which makes grasping an object or sewing clothes difficult. It can significantly reduce the quality of life.
The number of visually impaired patients is 285 million, which includes 246 million people of poor vision and 39 million people of blindness [Pascolini and Mariotti 2010]. The number of people losing sight in one eye is not published, however it is considered to be the same order to that of the visually impaired patients.
The major advance here is that we were able to make biodegradable nanoparticles that can rapidly penetrate thick and sticky mucus secretions, and that these particles can transport a wide range of therapeutic molecules.
Carlos Garcia Pando's insight:
Previous research demonstrated that latex particles coated with polyethylene glycol (PEG) could slip past mucus coatings, but latex particles are not practical for drug delivery because the body does not break them down. They now developed various types of biodegradable particles composed of an inner core that traps therapeutic agents inside, and a dense PEG outer coating that allows the particles to move easily through mucus. As the particles break down, they release drugs to the targeted tissues, including the lung airways in cases when the particles are inhaled
Rex, the Robotic Exoskeleton, is a pair of robotic legs that enables you to stand up and walk with your arms free, move sideways, turn around, go up and down steps. Rex can walk on flat hard surfaces including ramps and slopes.
Carlos Garcia Pando's insight:
Watching people like Sophie Morgan (pic) showing such a true happiness is the best reward for an engineer; it makes me feel I can do something for them sldo, or for other impairment sufferers, and actively find out how.
With twice as many electrodes in her brain as previous study participants, a paralyzed woman can move a robotic arm with unprecedented flexibility.
Carlos Garcia Pando's insight:
The arm, which was developed under a Defense Advanced Research Projects Agency contract, has 17 motors that control 26 joints in what is the most sophisticated artificial limb system in the world. “The arm was designed to be able to mimic a human limb,” says Michael McLoughlin, program manager for theModular Prosthetic Limb project, which is based at Johns Hopkins University in Maryland. The Johns Hopkins team has built six of the robotic limbs that are in use by different research groups in the U.S.
Every year, thousands of people across the world lose an arm or a leg. “Our technology helps amputees to control an artificial limb, in much the same way as their own biological hand or arm, via the person's own nerves and remaining muscles.
“Our technology helps amputees to control an artificial limb, in much the same way as their own biological hand or arm, via the person's own nerves and remaining muscles. This is a huge benefit for both the individual and to society”, says Max Ortiz Catalan, industrial doctoral student at Chalmers University of Technology in Sweden.
Bioprinting is an emerging technique used to fabricate viable, 3D tissue constructs through the precise deposition of cells and hydrogels in a layer-by-layer fashion.
Electrospinning of polycaprolactone fibers was alternated with inkjet printing of rabbit elastic chondrocytes suspended in a fibrin–collagen hydrogel in order to fabricate a five-layer tissue construct of 1 mm thickness. The chondrocytes survived within the printed hybrid construct with more than 80% viability one week after printing. In addition, the cells proliferated and maintained their basic biological properties within the printed layered constructs. Furthermore, the fabricated constructs formed cartilage-like tissues both in vitro and in vivo as evidenced by the deposition of type II collagen and glycosaminoglycans. Moreover, the printed hybrid scaffolds demonstrated enhanced mechanical properties compared to printed alginate or fibrin–collagen gels alone
This study demonstrates the feasibility of constructing a hybrid inkjet printing system using off-the-shelf components to produce cartilage constructs with improved biological and mechanical properties
The bebionic hand is one of the most advanced multi-articulating myoelectric hands on the market today. With an array of grip patterns and naturally compliant fingers, users of the bebionic hand are able to restore their independence.
Following the amputation, Nigel was initially fitted with a passive hand. As this was a purely cosmetic hand, Nigel was unable to use the hand functionally and was reliant on performing tasks with his remaining left hand.
Nigel’s second arm was a body powered hook. A body harness connected to the hook allowed Nigel to use his upper body to open and close the hook. Nigel found this prosthesis uncomfortable and not very functional so stopped wearing it.
Recently, Nigel was fitted with a bebionic v2 hand. He now uses the bebionic v2 hand everyday and likes the movement and realistic appearance although prefers to wear the black non-definition glove so it doesn’t look too real! He takes advantage of the many grip patterns the hand offers and can now do everyday tasks two-handed like driving, typing, shopping and washing his hands.
The Ankle Mimicking Prosthetic (AMP-) Foot 2.0 is an energy efficient powered transtibial prosthesis mimicking non-pathological ankle behaviour. The innovation of this study is to harvest energy from motion while storing energy produced by a low power electric motor. The stored energy is then released with a delay when necessary for push-off thanks to the use of a locking system.
A new validated and reliable measure of how well an adult amputee is able to perform everyday tasks with a prosthetic arm will help physical and occupational therapists, prosthetists, and doctors assess the progress that patients make during training with their new limb.
Obviously this has a great economic impact in this market, as any manufacturer can claim whatever advantages and % of success thanks to their systems, but a a standard, as in any other engineering or industrial sector, brings useful comparison.
Advanced exoskeleton promises more independence for people with paraplegia. A team of Vanderbilt engineers has developed a powered exoskeleton that enables people with severe spinal cord injuries to stand, walk, sit and climb stairs.
These devices act like an external skeleton. They strap in tightly around the torso. Rigid supports are strapped to the legs and extend from the hip to the knee and from the knee to the foot. The hip and knee joints are driven by computer-controlled electric motors powered by advanced batteries. Patients use the powered apparatus with walkers or forearm crutches to maintain their balance.
From a rehabilitation perspective the Vanderbilt design also has two potential advantages, Hartigan pointed out:
* The amount of robotic assistance adjusts automatically for users who have some muscle control in their legs. This allows them to use their own muscles while walking. When a user is totally paralyzed, the device does all the work. The other designs provide all the power all of the time. * It is the only wearable robot that incorporates a proven rehabilitation technology called functional electrical stimulation. FES applies small electrical pulses to paralyzed muscles, causing them to contract and relax. FES can improve strength in the legs of people with incomplete paraplegia. For complete paraplegics, FES can improve circulation, change bone density and reduce muscle atrophy.
Doctors may soon be using a system in the operating room that recognizes hand gestures as commands to tell a computer to browse and display medical images of the patient during a surgery.
Carlos Garcia Pando's insight:
Looks great. It's an advance with regards to navigation systems. Nevertheless I hope gestures with one hand don't imply unwanted or involuntary movements of the other hand whith maybe holding a needle inside someone's brain.
Manchester scientists develop a tiny molecular machine they hope one day could synthesize new drug molecules or new types of plastic.
Carlos Garcia Pando's insight:
Once again we are learning from nature how to improve our manufacturing processes.
In the past we learnt how to use living beings to perform some of our tasks and improve our quality of life: oxen to plough the fields, pull the carts, horses to take us faster, pigeons to deliver messages, etc. We also learnt how to take benefit from living cells: yeast, ferments, bacteriae, and the most acclaimed penicilium molds.
Then we invented and developed machines to "improve" -or so they thought and said- the efficiency of animals: cars, planes, and all types of mechanical monsters whose power delivery is still measured in horsepower equivalnce units. This approach served us well until it proved unsustainable: we grow crops to feed our machines and let people starve in hunger. Recently we are trying to use living cells as algae to produce fuel and food, but with nanotechnology we try to make the bottom-up approach work for us. Thanks to discoveries like this one here, we could "teach" certain cells to produce proteins or enzimes for us in large quantities, and still they will multiply autonmously to create more "workers" This is great, but... what if they grow out of control and invade our ecosystems? It has already happend with rabbits in Australia, mussels in rivers, flu in America with Spanish conquerors, etc.
Bioengineering scientists from Parabon Nanolabs have developed a new drug to fight gliobalstoma — a lethal brain cancer.– using a computer aided design (CAD) program linked to a special search platform and nano-scale, 3D printer. The technology allows a designed drug to be built, and then ‘printed out”, one atom/one molecule at a time, like a ‘molecular sentence’ on paper. The cancer-fighting drug was designed using a new DNA self-assembly technique enabled by a ‘drag and drop’ feature of the CAD program.
Carlos Garcia Pando's insight:
I knew ithis would happen, and here it is. Next step is printing traditional proteins or aminoacids. If we can make it it cheap, fast, and massive we could feed the hungry world
Olson’s solution consists of a fluorescent beacon attached to a peptide derived from scorpion toxin that latches onto cancer cells’ receptors. The technology is administered via injection, and surgeons use a near infrared camera to see the cancerous tissue in real time and at much higher resolution than MRI technology can provide.
Last year,Chia-Chi Ho of the University of Cincinnati and her colleagues demonstrated last year that they could steer the movement of cells by printing a cell-resistant polymer background that surrounded teardrop-shaped, unmodified islands on a tissue culture dish . Microarrays are a laboratory tool, also referred to as lab-on-a-chip, which allows the researchers to interact with living cells. Ho explains, "We can use microarrays to amplify the natural direction of cells and guide their continuous migration along preset paths and directions" she said.
The technology of steering and sorting cell migration will play a large role in the future of cancer metastasis and wound healing. This discovery may lead to diagnostic tools and further down the road, tissue engineering to grow body tissue and/or organs that are functional for transplants. For now, Ho intends to work with their current revelations, to continue efforts to sort disease and cancer related cells.
Tufts University School of Engineering researchers have demonstrated silk-based implantable optics that offer significant improvement in tissue imaging while simultaneously enabling photothermal therapy, administering drugs, and monitoring drug delivery.
In a breakthrough for nanotechnology and multiple sclerosis, a biodegradable nanoparticle turns out to be the perfect vehicle to stealthily deliver an antigen that tricks the immune system into stopping its attack on myelin and halt a model of relapsing remitting multiple sclerosis (MS) in mice, according to new Northwestern Medicine research.
The new nanotechnology also can be applied to a variety of immune-mediated diseases including Type 1 diabetes, food allergies and airway allergies such as asthma.
In the study, researchers attached myelin antigens to the nanoparticles and injected them intravenously into the mice. The particles entered the spleen, which filters the blood and helps the body dispose of aging and dying blood cells. There, the particles were engulfed by macrophages, a type of immune cell, which then displayed the antigens on their cell surface. The immune system viewed the nanoparticles as ordinary dying blood cells and nothing to be concerned about. This created immune tolerance to the antigen by directly inhibiting the activity of myelin responsive T cells and by increasing the numbers of regulatory T cells which further calmed the autoimmune response.
United States Patent Application number 20120290052 describes a method to treat epilepsy with the help of graphene.
The authors of the patent claim that cooling the brain by 1.2 degrees Celsius helps inhibit epileptic seizures. Cooling is provided by replacing the thermally insulating human skull by the thermally conductive graphene element, allowing heat to flow from the brain to the cooler scalp. Implementations to date have involved implantation of electronic coolers (Peltier elements) or complex structures such as heat pipes, and batteries, deep into the brain, the coolers being switched on only during a seizure to preserve battery life. None of the earlier methods can actually prevent a seizure, only reduce its duration and intensity by active cooling once it has started. The method proposed in the UofW patent is always on, does not require power, and prevents seizures before they occur.
Plasticell Therapeutics is a biotechnology company developing stem cell technologies to discover drugs that regenerate tissues of the human body.
Plasticell is a pioneering biotechnology company that specialises in the differentiation of stem cells to obtain cell types for a range of biomedical applications.
Plasticell’s proprietary Combinatorial Cell Culture (CombiCult™), is a bead-based high throughput screening platform developed specially for use in stem cell research. Using this technology Plasticell has successfully differentiated embryonic and adult stem cells into a variety of hard-to-obtain somatic lineages on behalf of numerous leading biotechnology and pharmaceutical industry clients.
Plasticell’s business model is to provide services to companies that wish to produce cells for research, and to form alliances with companies that manufacture cells for therapy.
Two men and their journey to find a solution - from 10,000 miles apart.
The current prototype is held in place by a hand mount, which acts like a glove and is formed to suit the amputee's hand. The prosthetic finger itself consists of a rigid lever arm, pulleys, and finger tip with grip pad. It’s an approach which is much less high-tech in comparison to some other prosthetic fingers; however, it’s also far more affordable, and significantly increases Richard's ability to pick up objects.
Semiconducting and metallic single-walled carbon nanotubes (s-SWNTs and m-SWNTs) were enriched by agarose gel chromatography and their photothermal and photodynamic effects were compared in H2O. Under near-infrared laser irradiation, s-SWNTs generated reactive oxygen species (ROS) more than m-SWNTs, whereas m-SWNTs produced heat more efficiently than s-SWNTs. More importantly, cancer cell killing by PDE of s-SWNTs has been disclosed for the first time.
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